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Intercalation and release of an anti-inflammatory drug into designed three-dimensionally layered double hydroxide nanostructure via calcination–reconstruction route

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Abstract

Synthesis and application of layered nanomaterials are known as emerging field in nanotechnology. Inorganic layered nanomaterials with nanometer scale, high aspect ratios, and large-surface area generate various scientific and technological interests in several potential areas of application such as separation technology, medical sciences, chromatography drug delivery, and catalysis. In this research, naproxen was opted as a unique model of the drug to intercalate into three-dimensional layered double hydroxide (LDH) nanostructures by calcination–reconstruction method. The designed-naproxen nanostructures were synthesized and used as novel drug nanocarriers. The synthesized nanomaterial characteristics were confirmed by FTIR, XRD, and SEM. The results of antibacterial activity indicated that homemade nanostructure can inhibit bacterial growth. Furthermore, MTT assay analysis showed that synthesized-nanostructure in physiological concentration has not cytotoxicity on C2C12 myoblast cells in vitro. Subsequent to intercalation with naproxen according to calcination–reconstruction method, the basal spacing of LDH increased to 2.62 nm from primary 0.77 nm in diameter, which confirms successful intercalation of naproxen into inserted layer of LDH by bridging interaction. Also, in-vitro drug release tests in PBS (pH 7.4) showed constant release profile for naproxen. Consequently, due to the facile and low-cost fabrication of three-dimensional LDH nanostructure, it can be considered as a potential alternative for traditional and high cost drug delivery.

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Acknowledgements

The authors would like to acknowledge Prof. Mohammad Saeid Hejazi for kind advice and providing the laboratory facilities and Dr. Houman Kahroba for his helpful comments.

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Author notes

  1. Elham Mansouri and Vahideh Tarhriz contributed equally to this work and should be considered as co-first authors.

Authors and Affiliations

  1. Molecular Medicine Research Center, Biomedicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran

    Elham Mansouri, Vahideh Tarhriz & Vahid Yousefi

  2. Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

    Azita Dilmaghani

  3. Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran

    Azita Dilmaghani

Authors
  1. Elham Mansouri
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  2. Vahideh Tarhriz
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  3. Vahid Yousefi
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  4. Azita Dilmaghani
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Contributions

Elham Mansouri, Vahideh Tarhriz and Vahid Yousefi conceived, designed and conducted experiments and analyzed data. Azita Dilmaghani provide the experimental materials. Vahideh Tarhriz and Vahid Yousefi wrote the manuscript. Vahideh Tarhriz and Azita dilmaghani revised and rechecked the manuscript.

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Correspondence to Azita Dilmaghani.

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Mansouri, E., Tarhriz, V., Yousefi, V. et al. Intercalation and release of an anti-inflammatory drug into designed three-dimensionally layered double hydroxide nanostructure via calcination–reconstruction route. Adsorption 26, 835–842 (2020). https://doi.org/10.1007/s10450-020-00217-4

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