Abstract
For several decades antimicrobial resistance has been a growing threat to the effective treatment of infections, so it is necessary to focus on a rational and effective use of the antibiotics already available. The development of new materials for controlled release of drug is a topic of high priority. Vancomycin (VAN) is a glycopeptide antibiotic used to treat infections caused by gram positive bacteria, and layered double hydroxides (LDH) are inorganic and biocompatible excipients that can provided a long drug release time. In this work, LDH-VAN complexes were synthesized by two methods: co-precipitation and reconstruction. They were characterized by XRD, FTIR, TG, DSC, SEM and EDS, together with dissolution and release kinetics, and electrophoretic mobilities. The coprecipitation samples resulted in particles with a homogeneous chemical composition where there is a rather intimate contact between VAN and the solid phase of the LDH. Reconstruction samples were heterogeneous, but presented higher drug content. There was a congruent dissolution of coprecipitation samples, with VAN being released at the same rate than Mg. Reconstruction samples, on the contrary, dissolved incongruently, with VAN being released much more rapidly than Mg. The rate of VAN release can be tuned and controlled in coprecipitated samples by simply controlling the solution pH.
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References
Aramendía, M., Avilés, Y., Borau, V., Luque, J., Marinas, J., Ruiz, J., Urbano, F.: Thermal decomposition og Mg/Al and Mg/Ga layered-double hydroxides: a spectroscopic study. J. Mater. Chem. 9, 1603–1607 (1999)
Becke, A.D.: Density-functional exchange-energy approximation with correct asymptotic behavior. Phys. Rev. A 38, 3098–3100 (1988). https://doi.org/10.1103/PhysRevA.38.3098
Bi, X., Zhang, H., Dou, L.: Layered double hydroxide-based nanocarriers for drug delivery. Pharmaceutics 6, 298–332 (2014). https://doi.org/10.3390/pharmaceutics6020298
Bravo-Suárez, Juan J., Páez-Mozo, Edgar A., Oyama, S.T.: Review of the synthesis of layered double hydroxides: a thermodynamic approach. Quim. Nova 27, 601–614 (2004)
Del Hoyo, C.: Layered double hydroxides and human health: an overview. Appl. Clay Sci. 36, 103–121 (2007). https://doi.org/10.1016/j.clay.2006.06.010
Dong, L., Yan, L., Hou, W.G., Liu, S.J.: Synthesis and release behavior of composites of camptothecin and layered double hydroxide. J. Solid State Chem. 183, 1811–1816 (2010). https://doi.org/10.1016/j.jssc.2010.05.035
Evans, D.G., Slade, R.C.T.: Structural aspects of layered double hydroxides. Struct. Bond. 119, 1–87 (2006). https://doi.org/10.1007/430_005
Frieri, M., Kumar, K., Boutin, A.: Antibiotic resistance. J. Inf. Public Health. 10, 369–378 (2017). https://doi.org/10.1016/j.jiph.2016.08.007
Frisch, M.J., et al.: Gaussview reference. Gaussian Inc., Wallingford (2003)
He, J., Wei, M., Li, B., Kang, Y., Evans, D.G., Duan, X.: Preparation of layered double hydroxides. Layer. Double Hydroxides. 119, 89–119 (2006). https://doi.org/10.1007/430_006
Huh, A.J., Kwon, Y.J.: “Nanoantibiotics”: a new paradigm for treating infectious diseases using nanomaterials in the antibiotics resistant era. J. Control. Release 156, 128–145 (2011). https://doi.org/10.1016/j.jconrel.2011.07.002
Kuthati, Y., Kankala, R.K., Lee, C.H.: Layered double hydroxide nanoparticles for biomedical applications: current status and recent prospects. Appl. Clay Sci. 112–113, 100–116 (2015). https://doi.org/10.1016/j.clay.2015.04.018
Lee, C., Yang, W., Parr, R.G.: Development of the Colle-Salvetti correlation-energy formula into a functional of the electron density. Phys. Rev. B. 37, 785–789 (1988). https://doi.org/10.1103/PhysRevB.37.785
Li, F., Jiang, X., Evans, D.G., Duan, X.: Structure and basicity of mesoporous materials from Mg/Al/In layered double hydroxides prepared by separate nucleation and aging steps method. J. Porous Mater. 12, 55–63 (2005). https://doi.org/10.1007/s10934-005-5234-z
Li, Y., Xu, J., Wang, F., Wang, B., Liu, L., Hou, W., Fan, H., Tong, Y., Zhang, J., Lu, Z.: Overprescribing in China, driven by financial incentives, results in very high use of antibiotics, injections, and corticosteroids. Health Aff. 31, 1075–1082 (2012). https://doi.org/10.1377/hlthaff.2010.0965
Liu, C., Hou, W., Li, L., Li, Y., Liu, S.: Synthesis and characterization of 5-fluorocytosine intercalated Zn-Al layered double hydroxide. J. Solid State Chem. 181, 1792–1797 (2008). https://doi.org/10.1016/j.jssc.2008.03.032
MacGowan, A., Macnaughton, E.: Antibiotic resistance. Med. (United Kingdom) 45, 622–628 (2017). https://doi.org/10.1016/j.mpmed.2017.07.006
Nakayama, H., Wada, N., Tsuhako, M.: Intercalation of amino acids and peptides into Mg-Al layered double hydroxide by reconstruction method. Int. J. Pharm. 269, 469–478 (2004). https://doi.org/10.1016/j.ijpharm.2003.09.043
Obadiah, A., Kannan, R., Ravichandran, P., Ramasubbu, A., Vasanth Kumar, S.: Nano hydrotalcite as a novel catalyst for biodiesel conversion. Dig. J. Nanomater. Biostruct. 7, 321–327 (2012)
Parello, M.L., Rojas, R., Giacomelli, C.E.: Dissolution kinetics and mechanism of Mg-Al layered double hydroxides: a simple approach to describe drug release in acid media. J. Colloid Interface Sci. 351, 134–139 (2010). https://doi.org/10.1016/j.jcis.2010.07.053
Patrick, J.: Vancomycin Solubility Study. Rep. to Off. generic drugs-FDA. (2008)
Pfeiffer, R.R.: Structural features of vancomycin. Rev. Inf. Dis. 3, 205–209 (1981)
Rao, S., Kupfer, Y., Pagala, M., Chapnick, E., Tessler, S.: Systemic absorption of oral vancomycin in patients with Clostridium diffi cile infection. Scand. J. Infect. Dis. 43, 386–388 (2011). https://doi.org/10.3109/00365548.2010.544671
Rives, V., del Arco, M., Martín, C.: Intercalation of drugs in layered double hydroxides and their controlled release: a review. Appl. Clay Sci. 88–89, 239–269 (2014). https://doi.org/10.1016/j.clay.2013.12.002
Rocha, J., Rives, V., Ulibarri, M.A.: Reconstruction of layered double hydroxides from calcined precursors: a powder XRD and 27Al MAS NMR study. J. Mater. Chem. 3, 2499–2503 (1999). https://doi.org/10.1039/A903231B
Rojas Delgado, R., De Pauli, C.P., Carrasco, C.B., Avena, M.J.: Influence of MII/MIII ratio in surface-charging behavior of Zn-Al layered double hydroxides. Appl. Clay Sci. 40, 27–37 (2008). https://doi.org/10.1016/j.clay.2007.06.010
Rojas, R., Jimenez-Kairuz, A.F., Manzo, R.H., Giacomelli, C.E.: Release kinetics from LDH-drug hybrids: effect of layers stacking and drug solubility and polarity. Colloids Surfaces A 463, 37–43 (2014). https://doi.org/10.1016/j.colsurfa.2014.09.031
Saha, S., Ray, S., Acharya, R., Chatterjee, T.K., Chakraborty, J.: Magnesium, zinc and calcium aluminium layered double hydroxide-drug nanohybrids: a comprehensive study. Appl. Clay Sci. 135, 493–509 (2017). https://doi.org/10.1016/j.clay.2016.09.030
Toutain, P.L., Del Castillo, J.R.E., Bousquet-Mélou, A.: The pharmacokinetic-pharmacodynamic approach to a rational dosage regimen for antibiotics. Res. Vet. Sci. 73, 105–114 (2002). https://doi.org/10.1016/S0034-5288(02)00039-5
Uhrich, K.E., Cannizzaro, S.M., Langer, R.S., Shakesheff, K.M.: Polymeric systems for controlled drug release. Chem. Rev. 99, 3181–3198 (1999). https://doi.org/10.1021/cr940351u
Ventola, C.L.: The antibiotic resistance crisis: part 1: causes and threats. P T A peer-reviewed. J. Formul. Manag. 40, 277–283 (2015)
Vucelic, M., Moggridge, G.D., Jones, W.: Thermal properties of terephthalate- and benzoate-intercalated LDH. J. Phys. Chem. 99, 8328–8337 (1995)
Wang, Z., Wang, E., Gao, L., Xu, L.: Synthesis and properties of Mg2Al layered double hydroxides containing 5-fluorouracil. J. Solid State Chem. 178, 736–741 (2005). https://doi.org/10.1016/j.jssc.2004.11.005
World Health Organization: Worldwide country situation analysis: response to antimicrobial resistance. WHO Press. 1–50 (2015)
Xu, Z.P., Jin, Y., Liu, S., Hao, Z.P., Lu, G.Q.: (Max): surface charging of layered double hydroxides during dynamic interactions of anions at the interfaces. J. Colloid Interface Sci. 326, 522–529 (2008). https://doi.org/10.1016/j.jcis.2008.06.062
Yang, Z., Liu, J., Gao, J., Chen, S., Huang, G.: Chitosan coated vancomycin hydrochloride liposomes: characterizations and evaluation. Int. J. Pharm. 495, 508–515 (2015). https://doi.org/10.1016/j.ijpharm.2015.08.085
Yoshihiko, M., Tetsuya, W., Yuya, I., Shirou, K.: Notes comparison of dissolution behavior of vancomycin hydrochloride preparations for injection. J. Pharm. Health Care Sci. 36, 77–84 (2010)
Zarif, M.S., Afidah, A.R., Abdullah, J.M., Shariza, A.R.: Physicochemical characterization of vancomycin and its complexes with β-cyclodextrin. Biomed. Res. 23, 513–520 (2012)
Zhang, X., Cresswell, M.: Alternative Inorganic Systems for Controlled Release Applications. (2016)
Zhao, Y., Jiao, Q.Z., Evans, D.G., Duan, X.: Mechanism of pore formation and structural characterization for mesoporous Mg–Al composite oxides. Sci. China Ser. B 45, 37–45 (2002). https://doi.org/10.1360/02yb9006
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This work was financed by UNS, ANPCYT and CONICET.
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Lopez, N.A., Luengo, C.V. & Avena, M.J. Uptake/release of vancomycin on/from Mg–Al layered double hydroxides. Adsorption 25, 1349–1360 (2019). https://doi.org/10.1007/s10450-019-00097-3
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DOI: https://doi.org/10.1007/s10450-019-00097-3