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Comparing multi-column chromatographic processes for purifying monosaccharides part I: A simplified approach

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Abstract

This work proposes a methodology for comparing different multi-column chromatographic processes (SMB, ISMB, SSMB) for purifying monosaccharides. The first step of the methodology consists in determining the flow rates associated with the different processes assuming that the columns are infinitely efficient. This allows deriving “idealized” operating conditions. In a second step, using the “idealized” conditions, the behavior of the real systems associated with columns of finite efficiencies are simulated with ChromWorks™ and compared. It is shown that the SMB performs better than single column elution chromatography, and that, for the application selected, ISMB and SSMB are very similar and perform better than SMB.

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Abbreviations

\(\text{BV}\) :

Volume normalized by the column volume

\(\bar{K}\) :

Henry’s coefficient

\(m\) :

Ratio of fluid flow rate to solid flowrate (TMB)

N :

Number of plates

\({{P}_{Fru}}\) :

Fructose purification factor

\(Q\) :

Fluid flow rate

\(\bar{Q}\) :

Solid flowrate (TMB)

\({{u}_{e}}\) :

Interstitial fluid velocity

\({{V}_{col}}\) :

Column volume

\({{X}_{Fru}}\) :

Fructose purity

\(\Delta {{t}_{inj}}\) :

Injection time

\(\Delta T\) :

Shift period

\(\Delta V\) :

Volume injected

\({{\varepsilon }_{e}}\) :

Extragranular porosity

\({{\theta }_{Fru}}\) :

Fructose recovery

\({{\Phi }_{Fru}}\) :

Fructose productivity

\({{\Upsilon }_{Fru}}\) :

Specific eluent consumption

eq:

Equilibrium model

ec, tmb, smb, ismb, ssmb:

Refer to chromatographic processes

I,II,III,IV:

Zones in TMB or SMB

E, F, Ext, Raf:

Eluent, Feed, Extract, Raffinate

BV:

Bed volume

ISMB:

Intermittent SMB

SMB:

Simulated moving bed

SSMB:

Sequential SMB

TMB:

True moving Bed

References

  • Agrawal, G., Kawajiri, Y.: Full superstructure for multiobjective optimization of multicolumn chromatography for ternary separations. Chem. Eng. Technol. 38, 1677–1682 (2015)

    Article  CAS  Google Scholar 

  • Baudouin, S., Lancrenon, X.: Desugarization of low purity syrups and molasses: the sequential simulated moving bed (SSMB) is a new step of progress in the development of chromatographic separation for two fractions systems. In: CITS Proceedings of the 22nd general assembly of the International Commission on Sugar Technology. pp. 295–302 (2003)

  • Biressi, G., Ludemann-Hombourger, O., Mazzotti, M., Nicoud, R.-M., Morbidelli, M.: Design and optimisation of a simulated moving bed unit: role of deviations from equilibrium theory. J. Chromatogr. A. 876, 3–15 (2000)

    Article  CAS  Google Scholar 

  • Carta, G., Mahajan, A.I., Cohen, L.M., Byers, C.H.: Chromatography of reversibly reacting mixtures: mutarotation effects in sugar separations. Chem. Eng. Sci. 47, 1645–1657 (1992)

    Article  CAS  Google Scholar 

  • Charton, F., Nicoud, R.-M.: Complete design of a simulated moving bed. J. Chromatogr. A. 702, 97–112 (1995)

    Article  CAS  Google Scholar 

  • Katsuo, S., Mazzotti, M.: Intermittent simulated moving bed chromatography: 1. Design criteria and cyclic steady-state. J. Chromatogr. A. 1217, 1217–1354 (2010a)

    Google Scholar 

  • Katsuo, S., Mazzotti, M.: Intermittent simulated moving bed chromatography: 2. Separation of Troger’s base enantiomers. J. Chromatogr. A. 1217, 3067–3075 (2010b)

    Article  CAS  Google Scholar 

  • Mazzotti, M., Storti, G., Morbidelli, M.: Robust design of countercurrent adsorption separation: 3. Nonstoichiometric systems. AIChE J. 42, 2784–2796 (1996)

    Article  CAS  Google Scholar 

  • Nicoud, R.-M.: The amazing ability of continuous chromatography to adapt to a moving environment. Ind. Eng. Chem. Res. 53, 3755–3765 (2014)

    Article  CAS  Google Scholar 

  • Nicoud, R.-M.: Chromatographic Processes: modeling, simulation and design. Cambridge University Press, New York (2015)

    Book  Google Scholar 

  • Ruthven, D.M., Ching, C.B.: Counter-current and simulated counter-current adsorption separation processes. Chem. Eng. Sci. 44, 1011–1038 (1989)

    Article  CAS  Google Scholar 

  • Sainio, T.: Unified Design of chromatographic processes with timed events: Separation of ternary mixtures. Chem. Eng. Sci. 152, 547–567 (2016)

    Article  CAS  Google Scholar 

  • Siitonen, J., Sainio, T.: Unified design of chromatographic separation processes. Chem. Eng. Sci. 122, 436–451 (2015)

    Article  CAS  Google Scholar 

  • Storti, G., Mazzotti, M., Morbidelli, M., Carrà, S.: Robust design of binary countercurrent adsorption separation processes. AIChE J. 39, 471–492 (1993)

    Article  CAS  Google Scholar 

  • Tanimura, M., Tamura, M., Teshima, T.: Method of chromatographic separation, US Patent No. 5,064,539, 12 Nov 1991

  • Tanimura, M., Tamura, M., Teshima, T.: Japanese Patent No. B-H07-046097, 1995

  • Ypso-Facto: Chromworks™, A software for chromatographic separations, http://www.ypsofacto.com/services-chemical-software-chromworks.php.

  • Zhang, Z., Mazzotti, M., Morbidelli, M.: Continuous chromatographic processes with a small number of columns: Comparison of simulated moving bed with Varicol, PowerFeed, and ModiCon. Korean J. Chem. Eng. 21, 454–464 (2004)

    Article  CAS  Google Scholar 

  • Zhong, G., Guiochon, G.: Analytical solution for the linear ideal model of simulated moving bed chromatography. Chem. Eng. Sci. 51, 4307–4319 (1996)

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Ypso-Facto, 10 Bd Kennedy, 54000, Nancy, France

    Laurent David, Jay Yun & Roger-Marc Nicoud

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  1. Laurent David
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  2. Jay Yun
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  3. Roger-Marc Nicoud
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Correspondence to Roger-Marc Nicoud.

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David, L., Yun, J. & Nicoud, RM. Comparing multi-column chromatographic processes for purifying monosaccharides part I: A simplified approach. Adsorption 23, 577–591 (2017). https://doi.org/10.1007/s10450-017-9878-1

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  • DOI: https://doi.org/10.1007/s10450-017-9878-1

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