Acta Biotheoretica

, Volume 62, Issue 4, pp 429–454 | Cite as

Heuristic Reevaluation of the Bacterial Hypothesis of Peptic Ulcer Disease in the 1950s

Regular Article

Abstract

Throughout the first half of the twentieth century the research on peptic ulcer disease (PUD) focused on two rivaling hypothesis: the “acidity” and the “bacterial” one. According to the received view, the latter was dismissed during the 1950s only to be revived with Warren’s and Marshall’s discovery of Helicobacter pylori in the 1980s. In this paper we investigate why the bacterial hypothesis was largely abandoned in the 1950s, and whether there were good epistemic reasons for its dismissal. Of special interest for our research question is Palmer’s 1954 large-scale study, which challenged the bacterial hypothesis with serious counter-evidence, and which by many scholars is considered as the shifting point in the research on PUD. However, we show that: (1) The perceived refutatory impact of Palmer’s study was disproportionate to its methodological rigor. This undermines its perceived status as a crucial experiment against the bacterial hypothesis. (2) In view of this and other considerations we argue that the bacterial hypothesis was worthy of pursuit in the 1950s.

Keywords

PUD Peptic ulcer disease Bacterial hypothesis  Crucial experiment Pursuit worthiness Heuristic appraisal 

References

  1. Atwood KC (2004) Bacteria, Ulcers, and Ostracism? H. Pylori and the Making of a Myth. Skeptical Inquirer 28(6):27–34Google Scholar
  2. Bartle HJ, Harkins MJ (1925) The gastric secretion: its bactericidal value to man. Am J Med Sci 169(3):373–388CrossRefGoogle Scholar
  3. Best RR, Orator V (1932) The vagus nerve and its relation to peptic ulcer. Ann Surg 96(2):184–191CrossRefGoogle Scholar
  4. Boettcher A (1874) Zur Genese des Perforierten Magengeschwürs. Dorpater Berichte 5:148–151Google Scholar
  5. Campbell RE, Rosahn PD (1950) The morphology and staining characteristics of the Treponema pallidum. Review of the literature and description of a new technique for staining the organism in tissues. Yale J Biol Med 22(6):527–543Google Scholar
  6. Carter KC (2003) The rise of causal concepts of disease: case histories. Ashgate Publishing Ltd., FarnhamGoogle Scholar
  7. Chai J (2011) Gastric ulcer healing-Role of serum response factor. In: Peptic Ulcer Disease. Rijeka, Croatia, In-tech, pp 143–164Google Scholar
  8. Conway EJ et al (1959) The location and origin of gastric urease. Gastroenterology 37:449–456Google Scholar
  9. Dintzis RZ, Hastings AB (1953) The effect of antibiotics on urea breakdown in mice. In: Proceedings of the National Academy of Sciences of the United States of America 39(7):571–578Google Scholar
  10. Doenges JL (1938) Spirochetes in gastric glands of Macacus rhesus and humans without definite history of related disease. In: Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, NY). Vol. 38. Royal Society of Medicine, pp 536–538Google Scholar
  11. Doenges JL (1939) Spirochetes in the gastric glands of Macacus rhesus and of man without related disease. Arch Pathol 27:469–477Google Scholar
  12. Edkins JS (1923) Spirella regaudi in the cat. Parasitology 15(03):296–307CrossRefGoogle Scholar
  13. Edwards LW et al (1963) The surgical treatment of duodenal ulcer by vagotomy and antral resection. Am J Surg 105(3):352–360CrossRefGoogle Scholar
  14. Freedberg A. Stone (2002) An early study of human stomach bacteria. In: Helicobacter pioneers: firsthand accounts from the scientists who discovered helicobacters, 1892–1982. Blackwell Science Asia, Victoria, pp 25–27Google Scholar
  15. Freedberg AS, Barron LE (1940) The presence of spirochetes in human gastric mucosa. Am J Dig Dis 7(10):443–445CrossRefGoogle Scholar
  16. Fukuda Y et al. (2002). Kasai, Kobayashi and Koch’s postulates in the history of Helicobacter pylori. In: Helicobacter pioneers: firsthand accounts from the scientists who discovered helicobacters, 1892–1982. Blackwell Science Asia, Victoria, pp 15–24Google Scholar
  17. Giannella RA, Broitman SA, Zamcheck N (1972) Gastric acid barrier to ingested microorganisms in man: studies in vivo and in vitro. Gut 13(4):251–256CrossRefGoogle Scholar
  18. Hollander F (1954) The two-component mucous barrier: its activity in protecting the gastroduodenal mucosa against peptic ulceration. Arch Int Med 93(1):107–120CrossRefGoogle Scholar
  19. Hood M, Arnold L (1937) The relation between the acid-base equilibrium and the gastric bacterial flora. Am J Dig Dis 4(2):95–99CrossRefGoogle Scholar
  20. Isenberg JI (1993) Is peptic ulcer disease an infectious disease? West J Med 159(5):616–618Google Scholar
  21. Ito S (2002). How I discovered helicobacters in Boston in 1967. In: Helicobacter pioneers: firsthand accounts from the scientists who discovered helicobacters, 1892–1982. Blackwell Science Asia, Victoria, pp 89–98Google Scholar
  22. Kidd M, Modlin IM (1998) A century of Helicobacter pylori. Digestion 59(1):1–15CrossRefGoogle Scholar
  23. Konturek SJ (2003) Gastric Secretion—From Pavlov’s Nervism to Popielski’s Histamine as Direct Secretagogue of Oxyntic Glands. J Physiol Pharmacol 54(S3):43–68Google Scholar
  24. Kornberg HL, Davies RE, Wood DR (1954) The activity and function of gastric urease in the cat. Biochem J 56(3):363–372Google Scholar
  25. Kornhauser SI (1930) The history of staining the development of cytological staining. Biotech Histochem 5(4):117–125CrossRefGoogle Scholar
  26. Lakatos I (1978) The methodology of scientific research programmes. Cambridge University Press, CambridgeCrossRefGoogle Scholar
  27. Lau WY, Leow CK, Arthur KCL (1997) History of endoscopic and laparoscopic surgery. World J Surg 21(4):444–453CrossRefGoogle Scholar
  28. Laudan L (1977) Progress and its problems. Routledge, LondonGoogle Scholar
  29. Lieber CS, Lefèvre A (1957) Effect of oxytetracycline on acidity, ammonia, and urea in gastric juice in normal and uremic subjects. Comptes rendus des séances de la Société de biologie et de ses filiales 151(5):1038–1042Google Scholar
  30. Lieber CS (2002) How it was discovered in Belgium and the USA (1955–1976) that gastric urease was caused by a bacterial infection. In: Helicobacter pioneers: firsthand accounts from the scientists who discovered helicobacters, 1892–1982. Blackwell Science Asia: Victoria, pp 39–51Google Scholar
  31. Lieber ChS, Lefèvre A (1959) Ammonia as a source of gastric hypoacidity in patients with uremia. J Clin Investig 38(8):1271–1277CrossRefGoogle Scholar
  32. Mann FC, Williamson CS (1923) The experimental production of peptic ulcer. Ann Surg 77(4):409–422CrossRefGoogle Scholar
  33. Marshall BJ (1995) Helicobacter pylori in peptic ulcer: have Koch’s postulates been fulfilled? Ann Med 27(5):565–568CrossRefGoogle Scholar
  34. Marshall BJ (2001) One Hundred Years of Discovery and Rediscovery of Helicobacter pylori and its Association with Peptic Ulcer Disease’. In: Hazell S L, Mobley H L T, Mendz GL, Helicobacter pylori: Physiology and Genetics, ASM Press: Washington, pp 19–24Google Scholar
  35. Marshall BJ (2002a). Helicobacter pioneers: firsthand accounts from the scientists who discovered helicobacters, 1892–1982. Blackwell Asia, VictoriaGoogle Scholar
  36. Marshall BJ (2002b). The discovery that Helicobacter pylori, a spiral bacterium, caused peptic ulcer disease. In: Helicobacter pioneers: firsthand accounts from the scientists who discovered helicobacters, 1892–1982. Blackwell Asia, Victoria, pp 165–202.Google Scholar
  37. Marshall BJ, Warren JR (1984) Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. Lancet 323(8390):1311–1315CrossRefGoogle Scholar
  38. May HG, Goodner K (1926) Cilia as Pseudo-spirochaetes. Trans Am Microsc Soc 45(4):302–305CrossRefGoogle Scholar
  39. O’Connor HJ, O’Morain CA (2002) Gastric Urease in Ulcer Patients in the 1940s: The Irish Connection. In: Helicobacter pioneers: firsthand accounts from the scientists who discovered helicobacters, 1892–1982. Blackwell Asia, Victoria, pp 29–38Google Scholar
  40. Palmer ED (1954) Investigation of the gastric mucosa spirochetes of the human. Gastroenterology 27(2):218–220Google Scholar
  41. Palmer WL, Nutter PB (1940) Peptic ulcer and achlorhydria: a further study of the role of acid gastric juice in the pathogenesis of peptic ulcer. Arch Int Med 65(3):499–509CrossRefGoogle Scholar
  42. Pindak FF, Clapper WE, Sherrod JH (1965) Incidence and distribution of spirochetes in the digestive tract of dogs. Am J Vet Res 26(115):1391–1402Google Scholar
  43. Ricketts WE et al (1949) Achlorhydria and peptic ulcer; a further study of the role of peptic activity in the pathogenesis and course of peptic ulcer. Ann Int Med 30(1):24–39CrossRefGoogle Scholar
  44. Rigas B, Efstathios DP (2002) John Lykoudis: the general practitioner in Greece who in 1958 discovered the etiology of, and a treatment for, peptic ulcer disease, In: Helicobacter pioneers: firsthand accounts from the scientists who discovered helicobacters, 1892–1982, Blackwell Asia, Victoria, pp 75–87Google Scholar
  45. Rolleston H (1933) A paper on changes in the character of diseases. British Med J 1(3768):499–500CrossRefGoogle Scholar
  46. Ryle JA (1948) Changing disciplines: lectures on the history, method, and motives of social pathology. Oxford University Press, LondonGoogle Scholar
  47. Sahyoun PF (1939) The differentiation between spirochetes and spirochetelike structures in the placenta. Am J Pathol 15(4):455–468Google Scholar
  48. Schlicke CP (1963) Complications of vagotomy. Am J Surg 106(2):206–216CrossRefGoogle Scholar
  49. Schwartz S, Susser E, Susser M (1999) A future for epidemiology? Ann Rev Public Health 20(1):15–33CrossRefGoogle Scholar
  50. Šešelja D, Kosolosky L, Straßer Ch (2012) Rationality of Scientific Reasoning in the Context of Pursuit: drawing appropriate distinctions. Philosophica 86:51–82Google Scholar
  51. Shay H (1961) Etiology of peptic ulcer. Am J Dig Dis 6(1):29–49CrossRefGoogle Scholar
  52. Solnick JV, Schauer DB (2001) Emergence of Diverse Helicobacter Species in the Pathogenesis of Gastric and Enterohepatic Diseases. Clin Microbiol Rev 14(1):59–97CrossRefGoogle Scholar
  53. Solomon M (2001) Social Empiricism. MIT press, CambridgeGoogle Scholar
  54. Steer HW (2002) The Discovery of Helicobacter pylori in England in the 1970s. In: Helicobacter pioneers: firsthand accounts from the scientists who discovered helicobacters, 1892–1982. Blackwell Asia, Victoria, pp 119–129Google Scholar
  55. Steiner G (1950) Modified silver stain of microorganisms in tissues. Am J Clin Pathol 20(5):489–490Google Scholar
  56. Suzuki H, Hibi T, Marshall BJ (2007) Helicobacter pylori: present status and future prospects in japan. J Gastroenterol 42(1):1–15CrossRefGoogle Scholar
  57. Thagard P (2000) How scientists explain disease. Princeton University Press, PrincetonGoogle Scholar
  58. Unge P (2002) Helicobacter pylori treatment in the past and in the 21st century. In: Helicobacter pioneers: firsthand accounts from the scientists who discovered helicobacters, 1892–1982. Blackwell Asia, Victoria, pp 203–215Google Scholar
  59. Vineis P (2003) Causality in epidemiology. Sozial-und Präventivmedizin 48(2):80–87Google Scholar
  60. Warren JR (2002) The discovery of Helicobacter pylori in Perth, Western Australia. In: Helicobacter pioneers: firsthand accounts from the scientists who discovered helicobacters, 1892–1982. Blackwell Science Asia: Victoria, pp 151–164Google Scholar
  61. Warren RJ, Marshall BJ (1983) Unidentified curved bacilli on gastric epithelium in active chronic gastritis. Lancet 321(8336):1273–1275CrossRefGoogle Scholar
  62. Warthin AS, Starry AC (1922) The staining of spirochetes in coverglass smears by the silver-agar method. J Infect Dis 30(6):592–600CrossRefGoogle Scholar
  63. Warthin AS (1929) A Silver-starch-gelatine Method for the Demonstration of Spirochetes in Single Tissue Sections. British J Vener Dis 5(4):255–266Google Scholar
  64. Wastell C (1967) Metabolic effects of vagotomy and gastric drainage. Postgrad Med J 43(501):481–486CrossRefGoogle Scholar
  65. Weber AF, Hasa O, Sautter JH (1958) Some observations concerning the presence of spirilla in the fundic glands of dogs and cats. Am J Veter Res 19(72):677–680Google Scholar
  66. Weber AF, Schmittdiel EF (1962) Electron microscopic and bacteriologic studies of spirilla isolated from the fundic stomachs of cats and dogs. Am J Vet Res 23:422–427Google Scholar
  67. Westblom TU, Bhatt BD (1999) Diagnosis of Helicobacter pylori infection. In: Gastroduodenal Disease and Helicobacter pylori. Springer, New York, pp 215–235Google Scholar
  68. Wolf S, Harold HG (1942) Evidence on the genesis of peptic ulcer in man. J Am Med Assoc 120(9):670–675CrossRefGoogle Scholar
  69. Zetzel L (1953) Treatment of peptic ulcer. New England J Med 248(23):976–982CrossRefGoogle Scholar
  70. Zollman KJS (2010) The epistemic benefit of transient diversity. Erkenntnis 72(1):17–35CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media Dordrecht 2014

Authors and Affiliations

  1. 1.Centre for Logic and Philosophy of ScienceGhent University (UGent)GhentBelgium

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