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A Mesoscale Computational Model for Microvascular Oxygen Transfer

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Abstract

We address a mathematical model for oxygen transfer in the microcirculation. The model includes blood flow and hematocrit transport coupled with the interstitial flow, oxygen transport in the blood and the tissue, including capillary-tissue exchange effects. Moreover, the model is suited to handle arbitrarily complex vascular geometries. The purpose of this study is the validation of the model with respect to classical solutions and the further demonstration of its adequacy to describe the heterogeneity of oxygenation in the tissue microenvironment. Finally, we discuss the importance of these effects in the treatment of cancer using radiotherapy.

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Acknowledgments

This work is supported by the AIRC - The Italian Foundation for Cancer Research - Investigator Grant IG21479 Mechanistic computational modelling of radiation damage to microvasculature and of its effect on tumour microenvironment.

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  1. Luca Possenti and Alessandro Cicchetti contributed equally to this study.

Authors and Affiliations

  1. Prostate Cancer Program, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy

    Luca Possenti, Alessandro Cicchetti & Tiziana Rancati

  2. LaBS, Department of Chemistry, Materials and Chemical Engineering “Giulio Natta”, Politecnico di Milano, Milan, Italy

    Luca Possenti, Riccardo Rosati & Maria Laura Costantino

  3. MOX, Department of Mathematics, Politecnico di Milano, Milan, Italy

    Daniele Cerroni & Paolo Zunino

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  1. Luca Possenti
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Correspondence to Alessandro Cicchetti.

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Possenti, L., Cicchetti, A., Rosati, R. et al. A Mesoscale Computational Model for Microvascular Oxygen Transfer. Ann Biomed Eng 49, 3356–3373 (2021). https://doi.org/10.1007/s10439-021-02807-x

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