Abuhattum, S., and D. Weihs. Asymmetry in traction forces produced by migrating preadipocytes is bounded to 33. Med. Eng. Phys. 38:834–838, 2016.
Albini, A., and R. Benelli. The chemoinvasion assay: a method to assess tumor and endothelial cell invasion and its modulation. Nat. Protoc. 2:504–511, 2007.
Alvarez-Elizondo, M. B., C. W. Li, A. Marom, Y.-T. Tung, G. Drillich, Y. Horesh, S. C. Lin, G.-J. Wang, and D. Weihs. Micropatterned topographies reveal measurable differences between cancer and benign cells. Med. Eng. Phys. 75:5–12, 2020.
Alvarez-Elizondo, M. B., and D. Weihs. Cell-gel mechanical interactions as an approach to rapidly and quantitatively reveal invasive subpopulations of metastatic cancer cells. Tissue Eng. Part C Methods 23:180–187, 2017.
Artym, V. V., K. M. Yamada, and S. C. Mueller. ECM degradation assays for analyzing local cell invasion. In: Methods in Molecular Biology (Clifton, N.J.). 2009, pp. 211–219.
Carrato, A., A. Falcone, M. Ducreux, J. W. Valle, A. Parnaby, K. Djazouli, K. Alnwick-Allu, A. Hutchings, C. Palaska, and I. Parthenaki. A systematic review of the burden of pancreatic cancer in Europe: real-world impact on survival, quality of life and costs. J. Gastrointest. Cancer 46:201–211, 2015.
Casciani, F., G. Marchegiani, G. Malleo, C. Bassi, and R. Salvia. Pancreatic cancer in the era of neoadjuvant therapy: a narrative overview. Chirurgia (Bucur) 113:307, 2018.
Cross, S. E., Y. S. Jin, J. Rao, and J. K. Gimzewski. Nanomechanical analysis of cells from cancer patients. Nat. Nanotechnol. 2:780–783, 2007.
Deer, E. L., J. Gonzalez-Hernandez, J. D. Coursen, J. E. Shea, J. Ngatia, C. L. Scaife, M. A. Firpo, and S. J. Mulvihill. Phenotype and genotype of pancreatic cancer cell lines. Pancreas 39:425–435, 2010.
Dvir, L., R. Nissim, M. B. Alvarez-Elizondo, and D. Weihs. Quantitative measures to reveal coordinated cytoskeleton-nucleus reorganization during in vitro invasion of cancer cells. New J. Phys. 17:043010, 2015.
Eslami Amirabadi, H., S. Saheb Ali, J. P. Frimat, R. Luttge, and J. M. J. Den Toonder. A novel method to understand tumor cell invasion: integrating extracellular matrix mimicking layers in microfluidic chips by “selective curing”. Biomed. Microdevices 19:1–11, 2017.
Friedl, P., and K. Wolf. Tumour-cell invasion and migration: diversity and escape mechanisms. Nat. Rev. Cancer 3:362–374, 2003.
Friedl, P., and K. Wolf. Plasticity of cell migration: a multiscale tuning model. J. Cell Biol. 188:11–19, 2010.
Gal, N., D. Lechtman-Goldstein, and D. Weihs. Particle tracking in living cells: a review of the mean square displacement method and beyond. Rheol. Acta 52:425–443, 2013.
Guck, J., S. Schinkinger, B. Lincoln, F. Wottawah, S. Ebert, M. Romeyke, D. Lenz, H. M. Erickson, R. Ananthakrishnan, D. Mitchell, J. Kas, S. Ulvick, and C. Bilby. Optical deformability as an inherent cell marker for testing malignant transformation and metastatic competence. Biophys. J. 88:3689–3698, 2005.
Gurcan, M. N., L. E. Boucheron, A. Can, A. Madabhushi, N. M. Rajpoot, and B. Yener. Histopathological image analysis: a review. IEEE Rev. Biomed. Eng. 2:147–171, 2009.
Holle, A. W., N. Govindan Kutty Devi, K. Clar, A. Fan, T. Saif, R. Kemkemer, and J. P. Spatz. Cancer cells invade confined microchannels via a self-directed mesenchymal-to-amoeboid transition. Nano Lett. 19:2280–2290, 2019.
Holliday, D. L., and V. Speirs. Choosing the right cell line for breast cancer research. Breast Cancer Res. 13:215, 2011.
Koch, T. M., S. Munster, N. Bonakdar, J. P. Butler, and B. Fabry. 3D Traction forces in cancer cell invasion. PLoS ONE 7:e33476, 2012.
Kraning-Rush, C. M., J. P. Califano, and C. A. Reinhart-King. Cellular traction stresses increase with increasing metastatic potential. PLoS ONE 7:e32572, 2012.
Kristal-Muscal, R., L. Dvir, and D. Weihs. Metastatic cancer cells tenaciously indent impenetrable, soft substrates. New J. Phys. 15:035022, 2013.
Levental, K. R., H. Yu, L. Kass, J. N. Lakins, M. Egeblad, J. T. Erler, S. F. T. Fong, K. Csiszar, A. Giaccia, W. Weninger, M. Yamauchi, D. L. Gasser, and V. M. Weaver. Matrix crosslinking forces tumor progression by enhancing integrin signaling. Cell 139:891–906, 2009.
Li, X., A. V. Valadez, P. Zuo, and Z. Nie. Microfluidic 3D cell culture: potential application for tissue-based bioassays. Bioassays. 4(12):1509–1525, 2012.
Liang, S. B., and L. W. Fu. Application of single-cell technology in cancer research. Biotechnol. Adv. 35(4):443–449, 2017.
Lloyd, S. Least squares quantization in PCM. IEEE Trans. Inf. Theory 28:129–137, 1982.
Massalha, S., and D. Weihs. Metastatic breast cancer cells adhere strongly on varying stiffness substrates, initially without adjusting their morphology. Biomech. Model. Mechanobiol. 16:961–970, 2017.
Merkher, Y., M. B. Alvarez-Elizondo, and D. Weihs. Taxol reduces synergistic, mechanobiological invasiveness of metastatic cells. Converg. Sci. Phys. Oncol. 3:044002, 2017.
Merkher, Y., and D. Weihs. Proximity of metastatic cells enhances their mechanobiological invasiveness. Ann. Biomed. Eng. 45:1399–1406, 2017.
Nyström, M., G. Thomas, M. Stone, I. Mackenzie, I. Hart, and J. Marshall. Development of a quantitative method to analyse tumour cell invasion in organotypic culture. J. Pathol. 205:468–475, 2005.
Peixoto, R. D., C. Speers, C. E. McGahan, D. J. Renouf, D. F. Schaeffer, and H. F. Kennecke. Prognostic factors and sites of metastasis in unresectable locally advanced pancreatic cancer. Cancer Med. 4:1171–1177, 2015.
Rahib, L., B. D. Smith, R. Aizenberg, A. B. Rosenzweig, J. M. Fleshman, and L. M. Matrisian. Projecting cancer incidence and deaths to 2030: the unexpected burden of thyroid, liver, and pancreas cancers in the United States. Cancer Res. 74:2913–2921, 2014.
Riihimaki, M., H. Thomsen, A. Hemminki, K. Sundquist, K. Hemminki, M. Riihimäki, H. Thomsen, A. Hemminki, K. Sundquist, K. Hemminki, M. Riihimaki, H. Thomsen, A. Hemminki, K. Sundquist, and K. Hemminki. Comparison of survival of patients with metastases from known versus unknown primaries: survival in metastatic cancer. BMC Cancer 13:36, 2013.
Sieuwerts, A. M., J. G. Klijn, and J. A. Foekens. Assessment of the invasive potential of human gynecological tumor cell lines with the in vitro Boyden chamber assay: influences of the ability of cells to migrate through the filter membrane. Clin. Exp. Metastasis 15:53–62, 1997.
Sleeman, J. P., I. Nazarenko, and W. Thiele. Do all roads lead to Rome? Routes to metastasis development. Int. J. Cancer 128:2511–2526, 2011.
Suker, M., B. R. Beumer, E. Sadot, L. Marthey, J. E. Faris, E. A. Mellon, B. F. El-Rayes, A. Wang-Gillam, J. Lacy, P. J. Hosein, S. Y. Moorcraft, T. Conroy, F. Hohla, P. Allen, J. Taieb, T. S. Hong, R. Shridhar, I. Chau, C. H. van Eijck, and B. G. Koerkamp. FOLFIRINOX for locally advanced pancreatic cancer: a systematic review and patient-level meta-analysis. Lancet Oncol. 17:801–810, 2016.
Sung, K. E., and D. J. Beebe. Microfluidic 3D models of cancer. Adv. Drug Deliv. Rev. 79–80:68–78, 2014.
Swaminathan, V., K. Mythreye, E. T. O’Brien, A. Berchuck, G. C. Blobe, and R. Superfine. Mechanical stiffness grades metastatic potential in patient tumor cells and in cancer cell lines. Cancer Res. 71:5075–5080, 2011.
Teng, Y., X. Xie, S. Walker, D. T. White, J. S. Mumm, and J. K. Cowell. Evaluating human cancer cell metastasis in zebrafish. BMC Cancer 13:453, 2013.
Toh, Y. C., A. Raja, H. Yu, and D. Van Noort. A 3D microfluidic model to recapitulate cancer cell migration and invasion. Bioengineering 5:10, 2018.
Truong, H. H., J. de Sonneville, V. P. S. S. Ghotra, J. Xiong, L. Price, P. C. W. W. Hogendoorn, H. H. Spaink, B. van de Water, and E. H. J. J. Danen. Automated microinjection of cell-polymer suspensions in 3D ECM scaffolds for high-throughput quantitative cancer invasion screens. Biomaterials 33:181–188, 2012.
Vinci, M., C. Box, and S. A. Eccles. Three-dimensional (3D) tumor spheroid invasion assay. J. Vis. Exp 2015. https://doi.org/10.3791/52686.
Wei, J. W., L. J. Tafe, Y. A. Linnik, L. J. Vaickus, N. Tomita, and S. Hassanpour. Pathologist-level classification of histologic patterns on resected lung adenocarcinoma slides with deep neural networks. Sci. Rep. 9:3358, 2019.
Weigelt, B., J. L. Peterse, and L. J. van’t Veer. Breast cancer metastasis markers and models. Nat. Rev. Cancer 5:591–602, 2005.
Weihs, D., and Y. Merkher. A device and method for determining cell indention activity, Patent pending. Patent: PCT/IL2019/050463, 2019.
Yankaskas, C. L., K. N. Thompson, C. D. Paul, M. I. Vitolo, P. Mistriotis, A. Mahendra, V. K. Bajpai, D. J. Shea, K. M. Manto, A. C. Chai, N. Varadarajan, et al. A microfluidic assay for the quantification of the metastatic propensity of breast cancer specimens. Nat. Biomed. Eng. 3:452–465, 2019.