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Magnetic Resonance Navigation for Targeted Embolization in a Two-Level Bifurcation Phantom

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Abstract

This work combines a particle injection system with our proposed magnetic resonance navigation (MRN) sequence with the intention of validating MRN in a two-bifurcation phantom for endovascular treatment of hepatocellular carcinoma (HCC). A theoretical physical model used to calculate the most appropriate size of the magnetic drug-eluting bead (MDEB, 200 μm) aggregates was proposed. The aggregates were injected into the phantom by a dedicated particle injector while a trigger signal was automatically sent to the MRI to start MRN which consists of interleaved tracking and steering sequences. When the main branch of the phantom was parallel to B0, the aggregate distribution ratio in the (left–left, left–right, right–left and right–right divisions was obtained with results of 8, 68, 24 and 0% respectively at baseline (no MRN) and increased to 84%, 100, 84 and 92% (p < 0.001, p = 0.004, p < 0.001, p < 0.001) after implementing our MRN protocol. When the main branch was perpendicular to B0, the right-left branch, having the smallest baseline distribution rate of 0%, reached 80% (p < 0.001) after applying MRN. Moreover, the success rate of MRN was always more than 92% at the 1st bifurcation in the experiments above.

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Abbreviations

DEB:

Drug-eluting bead

HCC:

Hepatocellular carcinoma

MRI:

Magnetic resonance imaging

MRN:

Magnetic resonance navigation

MDEB:

Magnetic drug-eluting bead

TACE:

Trans-catheter arterial chemoembolization

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Acknowledgments

This work was supported by a grant from the Natural Sciences and Engineering Research Council of Canada (NSERC), Operating Grant—CHRP (CIHR Partnered) (CHRP 478474-15) and Canadian Institutes of Health Research (CIHR), Operating Grant—CHRP (NSERC Partnered) (CPG-140179).

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Authors and Affiliations

  1. Polytechnique Montréal, Chemin de Polytechnique, 2500 Chemin de Polytechnique, Montréal, QC, 28 H3T 1J4, Canada

    Ning Li, Charles Tremblay, Samuel Kadoury & Sylvain Martel

  2. Laboratory of Clinical Image Processing, Le Centre de recherche du CHUM (CRCHUM), 900 Rue Saint-Denis, Montréal, QC, H2X 0A9, Canada

    Ning Li, Yuting Jiang, Rosalie Plantefève, Francois Michaud, Samuel Kadoury & Gilles Soulez

  3. Department of Radiology, Radiation-Oncology and Nuclear Medicine and Institute of Biomedical Engineering, Université de Montréal, 2900 Boulevard Édouard-Montpetit, Montréal, QC, H3T 1J4, Canada

    Yuting Jiang, Francois Michaud & Gilles Soulez

  4. University of British Columbia, 2405 Wesbrook Mall, Vancouver, BC, V6T 1Z3, Canada

    Zeynab Nosrati, Katayoun Saatchi & Urs O. Häfeli

  5. Siemens Canada, Oakville, ON, Canada

    Gerald Moran

  6. INRIA Paris, 2 rue Simone Iff, 75012, Paris, France

    Florian Joly

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  1. Ning Li
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  2. Yuting Jiang
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  3. Rosalie Plantefève
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Correspondence to Gilles Soulez.

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Li, N., Jiang, Y., Plantefève, R. et al. Magnetic Resonance Navigation for Targeted Embolization in a Two-Level Bifurcation Phantom. Ann Biomed Eng 47, 2402–2415 (2019). https://doi.org/10.1007/s10439-019-02317-x

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