Towards Alternative Approaches for Coupling of a Soft Robotic Sleeve to the Heart

Abstract

Efficient coupling of soft robotic cardiac assist devices to the external surface of the heart is crucial to augment cardiac function and represents a hurdle to translation of this technology. In this work, we compare various fixation strategies for local and global coupling of a direct cardiac compression sleeve to the heart. For basal fixation, we find that a sutured Velcro band adheres the strongest to the epicardium. Next, we demonstrate that a mesh-based sleeve coupled to the myocardium improves function in an acute porcine heart failure model. Then, we analyze the biological integration of global interface material candidates (medical mesh and silicone) in a healthy and infarcted murine model and show that a mesh interface yields superior mechanical coupling via pull-off force, histology, and microcomputed tomography. These results can inform the design of a therapeutic approach where a mesh-based soft robotic DCC is implanted, allowed to biologically integrate with the epicardium, and actuated for active assistance at a later timepoint. This strategy may result in more efficient coupling of extracardiac sleeves to heart tissue, and lead to increased augmentation of heart function in end-stage heart failure patients.

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Acknowledgments

The authors would like to thank Ronghli Liao Ph.D., Sudeshna Fisch Ph.D., and Souen Ngoy from the Brigham and Women’s Hospital Rodent Cardiovascular Physiology Core for their technical support; the staff at ARCH, Boston Children’s Hospital for help with porcine studies, James Weaver Ph.D. from the Wyss Institute at Harvard University for imaging assistance and Robert Padera M.D. Ph.D. for histological assessment. ETR acknowledges funding from the Massachusetts Institute of Technology (Institute for Medical Engineering Science and the Department of Mechanical Engineering), and the Wyss Institute for Biologically Inspired Engineering at Harvard University. WW and GD acknowledge the Irish Research Council (GOIPG/2017/927) and Science Foundation Ireland (SFI/12/RC/2278).

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Correspondence to Ellen T. Roche.

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Associate Editor Daniel Elson oversaw the review of this article.

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Horvath, M.A., Varela, C.E., Dolan, E.B. et al. Towards Alternative Approaches for Coupling of a Soft Robotic Sleeve to the Heart. Ann Biomed Eng 46, 1534–1547 (2018). https://doi.org/10.1007/s10439-018-2046-2

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Keywords

  • Direct cardiac compression
  • Ventricular assist devices
  • Device-tissue interface
  • Biointegration