Annals of Biomedical Engineering

, Volume 46, Issue 7, pp 927–939 | Cite as

Coupled Morphological–Hemodynamic Computational Analysis of Type B Aortic Dissection: A Longitudinal Study

  • Huijuan Xu
  • Marina Piccinelli
  • Bradley G. Leshnower
  • Adrien Lefieux
  • W. Robert Taylor
  • Alessandro Veneziani


Progressive false lumen aneurysmal degeneration in type B aortic dissection (TBAD) is a complex process with a multi-factorial etiology. Patient-specific computational fluid dynamics (CFD) simulations provide spatial and temporal hemodynamic quantities that facilitate understanding this disease progression. A longitudinal study was performed for a TBAD patient, who was diagnosed with the uncomplicated TBAD in 2006 and treated with optimal medical therapy but received surgery in 2010 due to late complication. Geometries of the aorta in 2006 and 2010 were reconstructed. With registration algorithms, we accurately quantified the evolution of the false lumen, while with CFD simulations we computed several hemodynamic indexes, including the wall shear stress (WSS), and the relative residence time (RRT). The numerical fluid model included large eddy simulation (LES) modeling for efficiently capturing the flow disturbances induced by the entry tears. In the absence of complete patient-specific data, the boundary conditions were based on a specific calibration method. Correlations between hemodynamics and the evolution field in time obtained by registration of the false lumen are discussed. Further testing of this methodology on a large cohort of patients may enable the use of CFD to predict whether patients, with originally uncomplicated TBAD, develop late complications.


Aortic dissection Point set registration Computational fluid dynamics Large eddy simulation 



Computational fluid dynamics


Aortic dissection


Type B AD


Uncomplicated TBAD


False lumen


True lumen


Optimal medical therapy


Wall shear stress


Time averaged WSS


Relative residence time


Oscillatory shear index


3 Element windkessel model



US-NSF Project DMS 162040 and NSF-XSEDE TG-ASC160069. The authors thank Professor R. Nerem for many fruitful discussions.

Supplementary material

10439_2018_2012_MOESM1_ESM.pdf (686 kb)
Supplementary material 1 (PDF 685 kb)


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Copyright information

© Biomedical Engineering Society 2018

Authors and Affiliations

  1. 1.The George W. Woodruff School of Mechanical EngineeringGeorgia Institute of TechnologyAtlantaUSA
  2. 2.Department of Mathematics and Computer ScienceEmory UniversityAtlantaUSA
  3. 3.Department of Radiology and Imaging SciencesEmory UniversityAtlantaUSA
  4. 4.Department of SurgeryEmory UniversityAtlantaUSA
  5. 5.Department of CardiologyEmory UniversityAtlantaUSA
  6. 6.Atlanta VA Medical CenterAtlantaUSA
  7. 7.School of Advanced Studies IUSSPaviaItaly

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