Fecobionics: A Novel Bionics Device for Studying Defecation
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During defecation, solid, semisolid or liquid stools are eliminated via the anus in a complex physiological process. Up to 25% of the population are affected by anorectal disorders that are poorly recognized and treated. We developed a new bionics device, a simulated stool named Fecobionics, to replace several current tests of anorectal function. Fecobionics was developed to simulate the defecation process that depends on rectal forces, the anorectal size angle, and anorectal size and sensitivity. Fecobionics provided axial pressure signatures, measurement of bending (anorectal angle) and geometric mapping in a single examination. It had the consistency and shape of normal stool. The device had a soft core with embedded electronics and a bag for distension. The paper describes the device development and validation. Furthermore, data were obtained in preliminary experiments in pigs, healthy human subjects and patients with focus on four important features of the system, i.e. measurements of pressure signatures, bending characteristics, impedance measurements and data transmission. Accurate pressure and orientation data as well as geometric profiles were successfully obtained on the bench as well as in vivo in pigs and human subjects during defecation. Fecobionics is a novel technology imitating defecation. The clinical future ultimately depends on its ability to impact on daily treatment of anorectal disorders. A potential long-term clinical application is use of the device for biofeedback training for dyssynergic defecation.
KeywordsAnal sphincter relaxation Anorectal physiology Bionics Defecation Fecobionics
The work was supported by a CUHK Start Up Grant, RCG Grant # 14106717, Karen Elise Jensens Foundation, and a NIH SBIR Phase 1 Grant. Simon Ng, Kaori Futaba, Tony Mak, Abbey Chen, Cherry Wong and Wing Wa are thanked for providing the data from patients. The authors had full access to all of the data, devices and materials used in the study and take complete responsibility for the integrity of the data and the accuracy of the data analysis and interpretation of outcomes.
Conflict of interest
Hans Gregersen has filed applications for patents on the technology.
- 3.Bock, D. C., A. C. Marschilok, K. J. Takeuchi, and E. S. Takeuchi. Batteries used to power implantable biomedical devices. Electrochim. Acta 1:84, 2012.Google Scholar
- 4.Caetano, A. C., A. Santa-Cruz, and C. Rolanda. Digital rectal examination and balloon expulsion test in the study of defecatory disorders: are they suitable as screening or excluding tests? Can. J. Gastroenterol. Hepatol. 2016:8654314, 2016; (Epub 26 Oct 2016).Google Scholar
- 6.Gregersen, H., and J. Christensen. Clinical Biomechanics in the Gut. An Introduction. Bentham Scientific Publishers, 2016. ISBN 978-1-68108-119-9 eISBN 978-1-68108-118-2.Google Scholar
- 8.Gregersen, H., K. Orvar, and J. Christensen. Biomechanical properties of duodenal wall and duodenal tone during phase I and phase II of the MMC. Am. J. Physiol. 263(Gastrointest Liver Physiol 26):G795–G801, 1992.Google Scholar
- 11.Jihansson, J. Wireless Communication with Medical Implants: Antennas and Propagation. Lund: Lund University Publications, p. 8, 2004.Google Scholar
- 14.Mehmer, Y., D. Tharaka, and K. Ho. Wireless telemetry for electronic pill technology. In: IEEE Xplore Conference, 2009. https://doi.org/10.1109/ICSENS.20095398440.
- 15.Mehmet, Y., and D. Tharaka. Easy-to-swallow wireless telemetry. IEEE Microw. Mag. 13:90–101, 2012.Google Scholar
- 22.US Food and Drug Administration. Radio Frequency Wireless Technology in Medical Devices: Guidance for Industry and Food and Drug Administration Staff. 2014.Google Scholar
- 23.Yamada, T. Textbook of Gastroenterology. Blackwell Pub., 2009, pp. 1717–1744. ISBN 9781405169110.Google Scholar