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Intestinal Mechanomorphological Remodeling Induced by Long-Term Low-Fiber Diet in Rabbits

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Abstract

Short-term feeding with low-fiber diet remodels the mechanomorphological properties in the rabbit small intestine. The aims were to study the effect of feeding low-fiber diet for 5 months on mechanomorphological properties including the collagen fraction in the rabbit intestines. Fifteen rabbits were divided into an Intervention group (IG, n = 10) fed a low-fiber diet and a Control group (CG, n = 5) fed a normal diet for 5 months. Five months later, four 10-cm-long segments obtained from the duodenum, jejunum, ileum and large intestine were used for histological and mechanical analysis, respectively. The wall thickness, wall area, mucosa and muscle layer thickness decreased whereas the submucosa layer thickness increased in the IG (p < 0.05). The collagen fraction decreased in all layers and segments in the IG (p < 0.05). The opening angle increased in the large intestine and decreased in the ileum in the IG (p < 0.05). The intestinal stress–strain curves for IG shifted to the right, indicating softening. The creep did not change in the four segments. The wall stiffness was associated with wall thickness and collagen fraction in the submucosa layer. Long-term low-fiber diet in rabbits induced histomorphometric and biomechanical remodelling of the intestines.

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Acknowledgments

The studies were financially supported by Grants from Chongqing Science and Technology Commission (cstc2013kjrc-ljrccj10003), National “111 Plan” Base (B06023) and Danish Karen Elise Jensen foundation. Yue Liu was partially supported by “The Short-term International Academic fund” of Chongqing University 2015 Overseas Visiting Student Project. These contributions did not constitute conflict of interest.

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Authors and Affiliations

  1. The Key Laboratory for Biorheological Science and Technology of Ministry of Education, Bioengineering College of Chongqing University, Chongqing, 400044, China

    Yue Liu & Guixue Wang

  2. Department of Clinical Medicine, GIOME Academia, Aarhus University, 8200, Aarhus N, Denmark

    Yue Liu, Jingbo Zhao & Donghua Liao

  3. Department of Surgery, GIOME, Chinese University of Hong Kong, Hong Kong SAR, China

    Hans Gregersen

  4. GIOME Center, College of Bioengineering, Room 305, Campus B of Chongqing University, Shapingba District, No. 83, Shabei Street, Chongqing, 400045, China

    Hans Gregersen

Authors
  1. Yue Liu
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  2. Jingbo Zhao
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  3. Donghua Liao
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  4. Guixue Wang
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  5. Hans Gregersen
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Correspondence to Hans Gregersen.

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Associate Editor Elena S. Di Martino oversaw the review of this article.

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Liu, Y., Zhao, J., Liao, D. et al. Intestinal Mechanomorphological Remodeling Induced by Long-Term Low-Fiber Diet in Rabbits. Ann Biomed Eng 45, 2867–2878 (2017). https://doi.org/10.1007/s10439-017-1922-5

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  • DOI: https://doi.org/10.1007/s10439-017-1922-5

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