Annals of Biomedical Engineering

, Volume 45, Issue 11, pp 2494–2508 | Cite as

Review of Mechanical Testing and Modelling of Thrombus Material for Vascular Implant and Device Design

  • S. JohnsonEmail author
  • S. Duffy
  • G. Gunning
  • M. Gilvarry
  • J. P. McGarry
  • P. E. McHugh


A thrombus or blood clot is a solid mass, made up of a network of fibrin, platelets and other blood components. Blood clots can form through various pathways, for example as a result of exposed tissue factor from vascular injury, as a result of low flow/stasis, or in very high shear flow conditions. Embolization of cardiac or vascular originating blood clots, causing an occlusion of the neurovasculature, is the major cause of stroke and accounts for 85% of all stroke. With mechanical thrombectomy emerging as the new standard of care in the treatment of acute ischemic stroke (AIS), the need to generate a better understanding of the biomechanical properties and material behaviour of thrombus material has never been greater, as it could have many potential benefits for the analysis and performance of these treatment devices. Defining the material properties of a thrombus has obvious implications for the development of these treatment devices. However, to-date this definition has not been adequately established. While some experimentation has been performed, model development has been extremely limited. This paper reviews the previous literature on mechanical testing of thrombus material. It also explores the use of various constitutive and computational models to model thrombus formation and material behaviour.


Clot material Mechanical characterization Computational modelling Mechanical thrombectomy Material behaviour Experimental testing 



The authors would like to acknowledge the support of Neuravi Ltd, the Irish Research Council Enterprise Partnership Scheme and the NUI Galway Hardiman Research Scholarship for this research.


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Copyright information

© Biomedical Engineering Society 2017

Authors and Affiliations

  1. 1.Biomechanics Research Centre (BMEC), Biomedical Engineering, College of Engineering and InformaticsNational University of IrelandGalwayIreland
  2. 2.Galway-Mayo Institute of TechnologyGalwayIreland
  3. 3.Neuravi LtdGalwayIreland

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