Annals of Biomedical Engineering

, Volume 45, Issue 2, pp 310–331

On the Mechanics of Transcatheter Aortic Valve Replacement

  • Lakshmi P. Dasi
  • Hoda Hatoum
  • Arash Kheradvar
  • Ramin Zareian
  • S. Hamed Alavi
  • Wei Sun
  • Caitlin Martin
  • Thuy Pham
  • Qian Wang
  • Prem A. Midha
  • Vrishank Raghav
  • Ajit P. Yoganathan
The Pursuit of Engineering the Ideal Heart Valve Replacement or Repair

DOI: 10.1007/s10439-016-1759-3

Cite this article as:
Dasi, L.P., Hatoum, H., Kheradvar, A. et al. Ann Biomed Eng (2017) 45: 310. doi:10.1007/s10439-016-1759-3

Abstract

Transcatheter aortic valves (TAVs) represent the latest advances in prosthetic heart valve technology. TAVs are truly transformational as they bring the benefit of heart valve replacement to patients that would otherwise not be operated on. Nevertheless, like any new device technology, the high expectations are dampened with growing concerns arising from frequent complications that develop in patients, indicating that the technology is far from being mature. Some of the most common complications that plague current TAV devices include malpositioning, crimp-induced leaflet damage, paravalvular leak, thrombosis, conduction abnormalities and prosthesis-patient mismatch. In this article, we provide an in-depth review of the current state-of-the-art pertaining the mechanics of TAVs while highlighting various studies guiding clinicians, regulatory agencies, and next-generation device designers.

Keywords

TAVR Transcatheter aortic valve Stent Minimally invasive Thrombosis Paravalvular leak Valve-in-valve 

Funding information

Funder NameGrant NumberFunding Note
American Heart Association
  • 16GRNT30980070
National Heart, Lung, and Blood Institute
  • R01HL119824

Copyright information

© Biomedical Engineering Society 2016

Authors and Affiliations

  • Lakshmi P. Dasi
    • 1
  • Hoda Hatoum
    • 1
  • Arash Kheradvar
    • 2
  • Ramin Zareian
    • 2
  • S. Hamed Alavi
    • 2
  • Wei Sun
    • 3
  • Caitlin Martin
    • 3
  • Thuy Pham
    • 3
  • Qian Wang
    • 3
  • Prem A. Midha
    • 3
  • Vrishank Raghav
    • 3
  • Ajit P. Yoganathan
    • 3
  1. 1.Department of Biomedical Engineering, Dorothy Davis Heart and Lung Research InstituteThe Ohio State UniversityColumbusUSA
  2. 2.The Edwards Lifesciences Center for Advanced Cardiovascular Technology, Department of Biomedical EngineeringUniversity of CaliforniaIrvineUSA
  3. 3.Wallace H. Coulter Department of Biomedical EngineeringGeorgia Institute of TechnologyAtlantaUSA

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