Annals of Biomedical Engineering

, Volume 45, Issue 2, pp 310–331 | Cite as

On the Mechanics of Transcatheter Aortic Valve Replacement

  • Lakshmi P. Dasi
  • Hoda Hatoum
  • Arash Kheradvar
  • Ramin Zareian
  • S. Hamed Alavi
  • Wei Sun
  • Caitlin Martin
  • Thuy Pham
  • Qian Wang
  • Prem A. Midha
  • Vrishank Raghav
  • Ajit P. Yoganathan
The Pursuit of Engineering the Ideal Heart Valve Replacement or Repair


Transcatheter aortic valves (TAVs) represent the latest advances in prosthetic heart valve technology. TAVs are truly transformational as they bring the benefit of heart valve replacement to patients that would otherwise not be operated on. Nevertheless, like any new device technology, the high expectations are dampened with growing concerns arising from frequent complications that develop in patients, indicating that the technology is far from being mature. Some of the most common complications that plague current TAV devices include malpositioning, crimp-induced leaflet damage, paravalvular leak, thrombosis, conduction abnormalities and prosthesis-patient mismatch. In this article, we provide an in-depth review of the current state-of-the-art pertaining the mechanics of TAVs while highlighting various studies guiding clinicians, regulatory agencies, and next-generation device designers.


TAVR Transcatheter aortic valve Stent Minimally invasive Thrombosis Paravalvular leak Valve-in-valve 



The authors gratefully acknowledge funding from the American Heart Association (Grant No. 16GRNT30980070) and National Institutes of Health (Grant Nos. HL119824, HL104080, HL108240 and HL127570). The content is solely the responsibility of the authors and does not necessarily represent the official views of the American Heart Association or the National Institutes of Health.


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Copyright information

© Biomedical Engineering Society 2016

Authors and Affiliations

  • Lakshmi P. Dasi
    • 1
  • Hoda Hatoum
    • 1
  • Arash Kheradvar
    • 2
  • Ramin Zareian
    • 2
  • S. Hamed Alavi
    • 2
  • Wei Sun
    • 3
  • Caitlin Martin
    • 3
  • Thuy Pham
    • 3
  • Qian Wang
    • 3
  • Prem A. Midha
    • 3
  • Vrishank Raghav
    • 3
  • Ajit P. Yoganathan
    • 3
  1. 1.Department of Biomedical Engineering, Dorothy Davis Heart and Lung Research InstituteThe Ohio State UniversityColumbusUSA
  2. 2.The Edwards Lifesciences Center for Advanced Cardiovascular Technology, Department of Biomedical EngineeringUniversity of CaliforniaIrvineUSA
  3. 3.Wallace H. Coulter Department of Biomedical EngineeringGeorgia Institute of TechnologyAtlantaUSA

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