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3D Bioprinting for Vascularized Tissue Fabrication

  • Additive Manufacturing of Biomaterials, Tissues, and Organs
  • Published:
Annals of Biomedical Engineering Aims and scope Submit manuscript

Abstract

3D bioprinting holds remarkable promise for rapid fabrication of 3D tissue engineering constructs. Given its scalability, reproducibility, and precise multi-dimensional control that traditional fabrication methods do not provide, 3D bioprinting provides a powerful means to address one of the major challenges in tissue engineering: vascularization. Moderate success of current tissue engineering strategies have been attributed to the current inability to fabricate thick tissue engineering constructs that contain endogenous, engineered vasculature or nutrient channels that can integrate with the host tissue. Successful fabrication of a vascularized tissue construct requires synergy between high throughput, high-resolution bioprinting of larger perfusable channels and instructive bioink that promotes angiogenic sprouting and neovascularization. This review aims to cover the recent progress in the field of 3D bioprinting of vascularized tissues. It will cover the methods of bioprinting vascularized constructs, bioink for vascularization, and perspectives on recent innovations in 3D printing and biomaterials for the next generation of 3D bioprinting for vascularized tissue fabrication.

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Acknowledgments

The work is supported by the National Institutes of Health (8P20 GM103444, U54 GM104941), the startup funds from Clemson University, the National Science Foundation (NSF - EPS-0903795), the NIH Cardiovascular Training Grant (T32 HL007260), and by NIH-NIGMS P30 GM103342 to the South Carolina COBRE for Developmentally Based Cardiovascular Diseases.

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Authors and Affiliations

  1. Bioengineering Department, Clemson University, Clemson, SC, 29634, USA

    Dylan Richards, Jia Jia & Ying Mei

  2. Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC, 29425, USA

    Michael Yost, Roger Markwald & Ying Mei

  3. Department of Surgery, Medical University of South Carolina, Charleston, SC, 29425, USA

    Michael Yost

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  1. Dylan Richards
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Correspondence to Ying Mei.

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Associate Editor Jos Malda oversaw the review of this article.

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Richards, D., Jia, J., Yost, M. et al. 3D Bioprinting for Vascularized Tissue Fabrication. Ann Biomed Eng 45, 132–147 (2017). https://doi.org/10.1007/s10439-016-1653-z

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