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Annals of Biomedical Engineering

, Volume 45, Issue 1, pp 148–163 | Cite as

3D Bioprinting for Tissue and Organ Fabrication

  • Yu Shrike Zhang
  • Kan Yue
  • Julio Aleman
  • Kamyar Mollazadeh-Moghaddam
  • Syeda Mahwish Bakht
  • Jingzhou Yang
  • Weitao Jia
  • Valeria Dell’Erba
  • Pribpandao Assawes
  • Su Ryon Shin
  • Mehmet Remzi Dokmeci
  • Rahmi Oklu
  • Ali Khademhosseini
Additive Manufacturing of Biomaterials, Tissues, and Organs

Abstract

The field of regenerative medicine has progressed tremendously over the past few decades in its ability to fabricate functional tissue substitutes. Conventional approaches based on scaffolding and microengineering are limited in their capacity of producing tissue constructs with precise biomimetic properties. Three-dimensional (3D) bioprinting technology, on the other hand, promises to bridge the divergence between artificially engineered tissue constructs and native tissues. In a sense, 3D bioprinting offers unprecedented versatility to co-deliver cells and biomaterials with precise control over their compositions, spatial distributions, and architectural accuracy, therefore achieving detailed or even personalized recapitulation of the fine shape, structure, and architecture of target tissues and organs. Here we briefly describe recent progresses of 3D bioprinting technology and associated bioinks suitable for the printing process. We then focus on the applications of this technology in fabrication of biomimetic constructs of several representative tissues and organs, including blood vessel, heart, liver, and cartilage. We finally conclude with future challenges in 3D bioprinting as well as potential solutions for further development.

Keywords

Bioprinting Additive manufacturing Bioink Tissue engineering Regenerative medicine 

Notes

Acknowledgments

The authors gratefully acknowledge funding from the Office of Naval Research Young National Investigator Award, the National Institutes of Health (EB012597, AR057837, DE021468, HL099073, R56AI105024), and the Presidential Early Career Award for Scientists and Engineers (PECASE).

Conflict of interest

The authors declare no conflict of interest.

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Copyright information

© Biomedical Engineering Society 2016

Authors and Affiliations

  • Yu Shrike Zhang
    • 1
    • 2
    • 3
  • Kan Yue
    • 1
    • 2
  • Julio Aleman
    • 1
    • 2
  • Kamyar Mollazadeh-Moghaddam
    • 1
    • 2
  • Syeda Mahwish Bakht
    • 1
    • 2
    • 4
  • Jingzhou Yang
    • 1
    • 2
    • 5
  • Weitao Jia
    • 1
    • 2
    • 6
  • Valeria Dell’Erba
    • 1
    • 2
    • 7
  • Pribpandao Assawes
    • 1
    • 2
  • Su Ryon Shin
    • 1
    • 2
    • 3
  • Mehmet Remzi Dokmeci
    • 1
    • 2
    • 3
  • Rahmi Oklu
    • 8
  • Ali Khademhosseini
    • 1
    • 2
    • 3
    • 9
    • 10
  1. 1.Biomaterials Innovation Research Center, Division of Biomedical Engineering, Department of Medicine, Brigham and Women’s HospitalHarvard Medical SchoolCambridgeUSA
  2. 2.Harvard-MIT Division of Health Sciences and TechnologyMassachusetts Institute of TechnologyCambridgeUSA
  3. 3.Wyss Institute for Biologically Inspired EngineeringHarvard UniversityBostonUSA
  4. 4.Comsats Institute of Information and TechnologyIslamabadPakistan
  5. 5.School of Mechanical and Chemical EngineeringUniversity of Western AustraliaPerthAustralia
  6. 6.Department of Orthopedic Surgery, Shanghai Jiaotong University Affiliated Sixth People’s HospitalShanghai Jiaotong UniversityShanghaiPeople’s Republic of China
  7. 7.Department of Biomedical EngineeringPolitecnico di TorinoTurinItaly
  8. 8.Division of Vascular & Interventional RadiologyMayo ClinicScottsdaleUSA
  9. 9.Department of Bioindustrial Technologies, College of Animal Bioscience and TechnologyKonkuk UniversitySeoulRepublic of Korea
  10. 10.Department of PhysicsKing Abdulaziz UniversityJeddahSaudi Arabia

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