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The Application of Three-Dimensional Printing in Animal Model of Augmentation Rhinoplasty

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Abstract

The role of three-dimensional (3D) printing has expanded in diverse areas in medicine. As plastic surgery needs to fulfill the different demands from diverse individuals, the applications of tailored 3D printing will become indispensable. In this study, we evaluated the feasibility of using 3D-printed polycaprolactone (PCL) scaffold seeded with fibrin/chondrocytes as a new dorsal augmentation material for rhinoplasty. The construct was surgically implanted on the nasal dorsum in the subperiosteal plane of six rabbits. The implants were harvested 4 and 12 weeks after implantation and evaluated by gross morphological assessment, radiographic imaging, and histologic examination. The initial shape of the implant was unchanged in all cases, and no definite post-operative complications were seen over the 3-month period. Radiologic evaluation confirmed that implants remained in the initial location without migration or extrusion. Histologic evaluations showed that the scaffold architectures were maintained with minimal inflammatory reactions; however, expected neo-chondrogenesis was not definite in the constructs. A new PCL scaffold designed by 3D printing method seeded with fibrin/chondrocytes can be a biocompatible augmentation material in rhinoplasty in the future.

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Acknowledgments

This work was supported by 2013 Ajou University Translational Research Center Fund (Seed type).

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None.

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Authors and Affiliations

  1. Department of Otolaryngology, Ajou University School of Medicine, 164 Worldcup Street, Wonchon-Dong, Yeongtong-Gu, Suwon, 442-749, Korea

    Yoo Suk Kim, Yoo Seob Shin, Jae Won Choi, Joo Kyung Park & Chul Ho Kim

  2. Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, Korea

    Do Yang Park

  3. Williston Northampton School, Easthampton, MA, USA

    Dong Ho Kim

  4. Nature-Inspired Mechanical System Team, Nano Convergence & Manufacturing Systems Research Division, Korea Institute of Machinery and Materials, Daejeon, Korea

    Su A. Park

Authors
  1. Yoo Suk Kim
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  2. Yoo Seob Shin
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  4. Jae Won Choi
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  5. Joo Kyung Park
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  6. Dong Ho Kim
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Correspondence to Chul Ho Kim.

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Associate Editor Scott I. Simon oversaw the review of this article.

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Kim, Y.S., Shin, Y.S., Park, D.Y. et al. The Application of Three-Dimensional Printing in Animal Model of Augmentation Rhinoplasty. Ann Biomed Eng 43, 2153–2162 (2015). https://doi.org/10.1007/s10439-015-1261-3

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  • DOI: https://doi.org/10.1007/s10439-015-1261-3

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