Naturally derived polymeric biomaterials, such as collagens, silks, elastins, alginates, and fibrins are utilized in tissue engineering due to their biocompatibility, bioactivity, and tunable mechanical and degradation kinetics. The use of these natural biopolymers in biomedical applications is advantageous because they do not release cytotoxic degradation products, are often processed using environmentally-friendly aqueous-based methods, and their degradation rates within biological systems can be manipulated by modifying the starting formulation or processing conditions. For these reasons, many recent in vivo investigations and FDA-approval of new biomaterials for clinical use have utilized natural biopolymers as matrices for cell delivery and as scaffolds for cell-free support of native tissues. This review highlights biopolymer-based scaffolds used in clinical applications for the regeneration and repair of native tissues, with a focus on bone, skeletal muscle, peripheral nerve, cardiac muscle, and cornea substitutes.
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We thank the NIH for support (P41 EB002520, R01 EB011620, R01 EY020856, R01 DE017207). W.L.S acknowledges funding from the Tufts University Training in Education and Critical Research Skills NIH IRACDA program (K12 GM074869).
Associate Editor Fei Wang oversaw the review of this article.
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Stoppel, W.L., Ghezzi, C.E., McNamara, S.L. et al. Clinical Applications of Naturally Derived Biopolymer-Based Scaffolds for Regenerative Medicine. Ann Biomed Eng 43, 657–680 (2015). https://doi.org/10.1007/s10439-014-1206-2
- Regenerative medicine