Improvement of Biodegradability, Bioactivity, Mechanical Integrity and Cytocompatibility Behavior of Biodegradable Mg Based Orthopedic Implants Using Nanostructured Bredigite (Ca7MgSi4O16) Bioceramic Coated via ASD/EPD Technique
- 524 Downloads
This research explored the influence of surface modification of AZ91 Mg alloy on the biodegradation, bioactivity, mechanical integrity and cytocompatibility of the alloy. For this purpose, a nanostructured bredigite (Ca7MgSi4O16) ceramic coating was prepared on biodegradable AZ91 Mg alloy through anodic spark deposition and electrophoretic deposition method. The phase composition and surface morphology of the coated alloy were characterized by X-ray diffraction, scanning electron microscope and transmission electron microscope. The properties of samples were investigated by electrochemical measurements, immersion test, compression examination and cell culturing. The results showed that the degradation resistance, bioactivity, mechanical integrity and cytocompatibility of biodegradable Mg alloy were improved by the anodic spark deposition and electrophorretic deposition of the nanostructured bredigite coating. Therefore, the nanostructured bredigite ceramic coating is identified as a good coating for AZ91 Mg alloy for the purpose of making biodegradable metallic orthopedic implants.
KeywordsBiomaterials Biodegradable Mg alloy Bredigite Coating Biomedical applications
The authors are thankful for the contributions of Isfahan University of Technology, Torabinejad Dental Research Center. The work is partially supported by Oklahoma Center for Advancement of Science and Technology (Grant No. AR131-054 8161), AFOSR (Grant No. FA9550-10-1-0010) and the National Science Foundation (NSF, Grant No. 0933763).
- 1.Anthony, J. W., R. Bideaux, K. Bladh, and M. C. Nichols. Handbook of Mineralogy. Tucson: Mineral Data Publishing, 1990.Google Scholar
- 7.Geng, F., L. Tan, B. Zhang, C. Wu, Y. He, J. Yang, et al. Study on beta-TCP coated porous Mg as a bone tissue engineering scaffold material. J. Mater. Sci. Technol. 25:123–129, 2009.Google Scholar
- 9.Grace, L. H. Y., and T. Y. Wah. Effect of collagen gel structure on fibroblast phenotype. J. Emerg. Invest. 2012. http://www.emerginginvestigators.org/2012/11/effect-of-collagen-gel-structure-on-fibroblast-phenotype/.
- 14.Kumari, T., U. Vasudev, A. Kumar, and B. Menon. Cell surface interactions in the study of biocompatibility. Trends Biomater. Artif. Organs 15:37–41, 2002.Google Scholar
- 18.Mozafari, M., M. Mehrayin, D. Vashaee, and L. Tayebi. Electroconductive nanocomposite scaffolds: a new strategy into tissue engineering and regenerative medicine, Nanocomposites—New Trends and Developments. InTech, 2012 (ISBN 978-953-51-0762-0).Google Scholar
- 24.Razavi, M., M. Fathi, O. Savabi, and M. Boroni. A review of degradation properties of Mg based biodegradable implants. Res. Rev. Mater. Sci. Chem. 1:15–58, 2012.Google Scholar
- 28.Razavi, M., M. Fathi, O. Savabi, D. Vashaee, and L. Tayebi. In vitro evaluations of anodic spark deposited AZ91 alloy as biodegradable metallic orthopedic implant. Ann. Res. Rev. Biol. 4:3716–3733, 2014.Google Scholar
- 31.Shahini, A., M. Yazdimamaghani, K. J. Walker, M. A. Eastman, H. Hatami-Marbini, B. J. Smith, et al. 3D conductive nanocomposite scaffold for bone tissue engineering. Int. J. Nanomed. 9:167, 2014.Google Scholar
- 42.Wu, C., J. Chang, W. Zhai, and S. Ni. A novel bioactive porous bredigite (Ca7MgSi4O16) scaffold with biomimetic apatite layer for bone tissue engineering. J. Mater. Sci. 18:857–864, 2007.Google Scholar
- 46.Yazdimamaghani, M., D. Vashaee, S. Assefa, K. Walker, S. Madihally, G. Köhler, et al. Hybrid macroporous gelatin/bioactive-glass/nanosilver scaffolds with controlled degradation behavior and antimicrobial activity for bone tissue engineering. J. Biomed. Nanotechnol. 10:911–931, 2014.PubMedCrossRefGoogle Scholar
- 47.Yazdimamaghani, M., M. Razavi, D. Vashaee, and L. Tayebi. Development and degradation behavior of magnesium scaffolds coated with polycaprolactone for bone tissue engineering. Mater. Lett. 132:106–110, 2014.Google Scholar
- 48.Yazdimamaghani, M., M. Razavi, D. Vashaee, and L. Tayebi. Microstructural and mechanical study of PCL coated Mg scaffolds. Surf. Eng. 2014. doi: 10.1179/1743294414Y.0000000307.