Annals of Biomedical Engineering

, Volume 42, Issue 7, pp 1413–1423

Microstructured Extracellular Matrices in Tissue Engineering and Development: An Update


DOI: 10.1007/s10439-013-0912-5

Cite this article as:
Tien, J. & Nelson, C.M. Ann Biomed Eng (2014) 42: 1413. doi:10.1007/s10439-013-0912-5


Microstructured extracellular matrix (ECM), which contains heterogeneous features of the same size scale (5–100 μm) as tissue organoids, has become an important material for the engineering of functional tissues and for the study of tissue-level biology. This review describes methods to generate this class of ECM, and highlights recent advances in the application of microstructured ECM to problems in basic and applied biology. It also discusses computational techniques to analyze and optimize the microstructural patterns for a desired functional output.


Biomimicry Bio-inspired design Micropatterning Soft lithography Multi-scale biomaterials 

Copyright information

© Biomedical Engineering Society 2013

Authors and Affiliations

  1. 1.Department of Biomedical EngineeringBoston UniversityBostonUSA
  2. 2.Division of Materials Science and EngineeringBoston UniversityBrooklineUSA
  3. 3.Department of Chemical and Biological EngineeringPrinceton UniversityPrincetonUSA
  4. 4.Department of Molecular BiologyPrinceton UniversityPrincetonUSA

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