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MRI-Apparent Localized Deformation of the Median Nerve Within the Carpal Tunnel During Functional Hand Loading

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Abstract

In MR images, the median nerve of carpal tunnel syndrome (CTS) patients frequently appears flatter than in healthy subjects. The purpose of this work was to develop a metric to quantify localized median nerve deformation rather than global nerve flattening, the hypothesis being that localized median nerve deformation would be elevated in CTS patients. Twelve patients with CTS and 12 matched normals underwent MRI scanning in eight isometrically loaded hand conditions. 2D cross sections of the proximal and distal tunnel were analyzed for nerve cross sectional area, flattening ratio, and a position shift to the dorsal side of the tunnel. Additionally, new metrics based on the angulation of the nerve perimeter in 0.5-mm lengths around the boundary were calculated. The localized deformation metrics were able to detect differences between CTS patients and healthy subjects that could not be appreciated from the flattening ratio. During most hand activities, normal subjects had a higher average percentage of locally deformed nerve boundary than did CTS patients, despite having a rounder overall shape. Less local nerve deformation in the CTS patient group resulting from its interaction with flexor tendons suggests that the nerve may be less compliant in CTS patients.

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Acknowledgment

We would like to acknowledge Dr. M. Bridget Zimmerman for her help regarding statistics.

Conflict of interest

This work was funded by National Institutes of Health Grant AR053899. No benefits in any form have been or will be received from a commercial party related directly or indirectly to the subject of this manuscript.

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Authors and Affiliations

  1. Department of Orthopaedics and Rehabilitation, University of Iowa, 200 Hawkins Drive, 01008 JPP, Iowa City, IA, 52242, USA

    Jessica E. Goetz, Nicole M. Kunze, Erin K. Main, Thomas E. Baer, Ericka A. Lawler & Thomas D. Brown

  2. Department of Biomedical Engineering, University of Iowa, 1402 Seamans Center, Iowa City, IA, 52242, USA

    Jessica E. Goetz & Thomas D. Brown

  3. Department of Radiology, University of Iowa, 200 Hawkins Drive, 3970 JPP, Iowa City, IA, 52242, USA

    Daniel R. Thedens

Authors
  1. Jessica E. Goetz
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  2. Nicole M. Kunze
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  3. Erin K. Main
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  4. Daniel R. Thedens
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  5. Thomas E. Baer
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  6. Ericka A. Lawler
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  7. Thomas D. Brown
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Correspondence to Jessica E. Goetz.

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Associate Editor Eiji Tanaka oversaw the review of this article.

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Goetz, J.E., Kunze, N.M., Main, E.K. et al. MRI-Apparent Localized Deformation of the Median Nerve Within the Carpal Tunnel During Functional Hand Loading. Ann Biomed Eng 41, 2099–2108 (2013). https://doi.org/10.1007/s10439-013-0809-3

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  • DOI: https://doi.org/10.1007/s10439-013-0809-3

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