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Assessment of Material By-Product Fate from Bioresorbable Vascular Scaffolds

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Abstract

Fully bioresorbable vascular scaffolds (BVS) are attractive platforms for the treatment of ischemic artery disease owing to their intrinsic ability to uncage the treated vessel after the initial scaffolding phase, thereby allowing for the physiological conditioning that is essential to cellular function and vessel healing. Although scaffold erosion confers distinct advantages over permanent endovascular devices, high transient by-product concentrations within the arterial wall could induce inflammatory and immune responses. To better understand these risks, we developed in this study an integrated computational model that characterizes the bulk degradation and by-product fate for a representative BVS composed of poly(l-lactide) (PLLA). Parametric studies were conducted to evaluate the relative impact of PLLA degradation rate, arterial remodeling, and metabolic activity on the local lactic acid (LA) concentration within arterial tissue. The model predicts that both tissue remodeling and PLLA degradation kinetics jointly modulate LA fate and suggests that a synchrony of these processes could minimize transient concentrations within local tissue. Furthermore, simulations indicate that LA metabolism is a relatively poor tissue clearance mechanism compared to convective and diffusive transport processes. Mechanistic understanding of factors governing by-product fate may provide further insights on clinical outcome and facilitate development of future generation scaffolds.

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Acknowledgments

This study was supported by the NIH grant (R01 GM-49039) to ERE and the National Science Foundation/EPSCoR Grant (EPS-0903795) to TS. The authors thank Tecplot, Inc. for generously providing software licenses for data visualization.

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Authors and Affiliations

  1. College of Engineering and Computing, Department of Mechanical Engineering and Biomedical Engineering, University of South Carolina, Columbia, SC, 29208, USA

    Tarek Shazly & Jahid Ferdous

  2. Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA

    Vijaya B. Kolachalama & Elazer R. Edelman

  3. Abbott Vascular, Santa Clara, CA, 95054, USA

    James P. Oberhauser & Syed Hossainy

  4. Cardiovascular Division, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, 02115, USA

    Elazer R. Edelman

Authors
  1. Tarek Shazly
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  2. Vijaya B. Kolachalama
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  3. Jahid Ferdous
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  4. James P. Oberhauser
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  5. Syed Hossainy
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  6. Elazer R. Edelman
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Corresponding author

Correspondence to Tarek Shazly.

Additional information

Associate Editor Kent Leach oversaw the review of this article.

Tarek Shazly and Vijaya B. Kolachalama contributed equally in this study.

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Shazly, T., Kolachalama, V.B., Ferdous, J. et al. Assessment of Material By-Product Fate from Bioresorbable Vascular Scaffolds. Ann Biomed Eng 40, 955–965 (2012). https://doi.org/10.1007/s10439-011-0445-8

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  • DOI: https://doi.org/10.1007/s10439-011-0445-8

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