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Regulation of the Matrix Microenvironment for Stem Cell Engineering and Regenerative Medicine

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Abstract

The extracellular matrix (ECM) microenvironment consists of structural and functional molecules. The ECM relays both biochemical and biophysical cues to and from the cells to modulate cell behavior and function. The biophysical cues can be engineered and applied to cells by means of spatial patterning, matrix rigidity, and matrix actuation. Tissue engineering strategies that utilize ECMs to direct stem cell organization and lineage specification show tremendous potential. This review describes the technologies for modulating ECM spatial patterning, matrix rigidity, chemical composition, and matrix actuation. The role of ECMs in vascular tissue engineering is then discussed as a model of tissue engineering and regenerative medicine.

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Acknowledgment

This work was support in part by research grants from the American Heart Association (to N.H.) and National Institutes of Health (HL098688-01A1 to N.H.; HL083900 and EB12240 to S.L.).

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Authors and Affiliations

  1. Division of Cardiovascular Medicine, Stanford University, 300 Pasteur Drive, MC 5406, Stanford, CA, 94305-5406, USA

    Ngan F. Huang

  2. Department of Bioengineering, University of California Berkeley, MC 1762, Berkeley, CA, 94720-1762, USA

    Song Li

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  1. Ngan F. Huang
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  2. Song Li
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Correspondence to Song Li.

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Associate Editor Daniel Takashi Kamei oversaw the review of this article.

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Huang, N.F., Li, S. Regulation of the Matrix Microenvironment for Stem Cell Engineering and Regenerative Medicine. Ann Biomed Eng 39, 1201–1214 (2011). https://doi.org/10.1007/s10439-011-0297-2

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  • DOI: https://doi.org/10.1007/s10439-011-0297-2

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