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The Application of Ink-Jet Technology for the Coating and Loading of Drug-Eluting Stents

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Abstract

The combination of drugs with devices, where locally delivered drugs elute from the device, has demonstrated distinct advantages over therapies involving systemic or local drugs and devices administered separately. Drug-eluting stents are most notable. Ink jet technology offers unique advantages for the coating of very small medical devices with drugs and drug-coating combinations, especially in cases where the active pharmaceutical agent is very expensive to produce and wastage is to be minimized. For medical devices such as drug-containing stents, the advantages of ink-jet technology result from the controllable and reproducible nature of the droplets in the jet stream and the ability to direct the stream to exact locations on the device surfaces. Programmed target deliveries of 100 μg drug, a typical dose for a small stent, into cuvettes gave a standard deviation (SD) of dose of 0.6 μg. Jetting on coated, uncut stent tubes exhibited 100% capture efficiency with a 1.8 μg SD for a 137 μg dose. In preliminary studies, continuous jetting on stents can yield efficiencies up to 91% and coefficients of variation as low as 2%. These results indicate that ink-jet technology may provide significant improvement in drug loading efficiency over conventional coating methods.

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Acknowledgment

David Werst, of Abbott Pharmaceutical Development, kindly provided the analysis of drug release from the stents.

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Authors and Affiliations

  1. Department of Advanced Drug Delivery, Abbott Laboratories, D-R43D, Bldg, AP4-2, 100 Abbott Park Road, Abbott Park, North Chicago, IL, 60064, USA

    Peter J. Tarcha, Donald Verlee & Ho Wah Hui

  2. Hospira, Lake Forest, IL, USA

    Ho Wah Hui & Jeff Setesak

  3. Department of Engineering, Abbott Laboratories, D-R43D, Bldg, AP4-2, 100 Abbott Park Road, Abbott Park, North Chicago, IL, 60064, USA

    Jeff Setesak

  4. MicroFab Technologies, 1104 Summit Ave, Plano, TX, 75074, USA

    Bogdan Antohe, Delia Radulescu & David Wallace

Authors
  1. Peter J. Tarcha
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  2. Donald Verlee
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  3. Ho Wah Hui
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  4. Jeff Setesak
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  5. Bogdan Antohe
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  6. Delia Radulescu
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  7. David Wallace
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Corresponding author

Correspondence to Peter J. Tarcha.

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Tarcha, P.J., Verlee, D., Hui, H.W. et al. The Application of Ink-Jet Technology for the Coating and Loading of Drug-Eluting Stents. Ann Biomed Eng 35, 1791–1799 (2007). https://doi.org/10.1007/s10439-007-9354-2

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  • DOI: https://doi.org/10.1007/s10439-007-9354-2

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