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The Estimation of Lung Mechanics Parameters in the Presence of Pathology: A Theoretical Analysis

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Mechanical lung function is frequently assessed in terms of lung resistance (R L), lung elastance (E L), and airway resistance (R aw). These quantities are determined by measuring input impedance at various oscillation frequencies, and allow lung tissue resistance (R t) to be estimated as the difference between R L and R aw. These various parameters change in characteristic ways in the presence of lung pathology. In particular, the ratio R t/E L (known as hysteresivity, (η) has been shown both experimentally and in numerical simulations to increase when regional heterogeneities in mechanical function develop throughout the lung. In this study, we performed an analytical investigation of a two-compartment lung model and showed that while heterogeneity always leads to an increase in E L, η will increase only initially. When heterogeneity becomes extreme, η stops increasing and starts to decrease. However, there are no experimental reports of η decreasing under conditions in which heterogeneity would be expected to exist. We speculate that this is because liquid bridges invariably form across airway lumen that narrow to a certain point, thereby preventing them from achieving arbitrarily small non-zero radii. We also show that recruitment of closed lung units during lung inflation may lead to variables responses in both η and E L.

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ACKNOWLEDGMENTS

This work was supported by NIH grants nos. R01 HL67273 and NCRR-COBRE P20 RR15557.

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Authors and Affiliations

  1. Vermont Lung Center Departments of Medicine and Molecular Physiology and Biophysics, University of Vermont Burlington, Burlington, VT, 05405-0075, USA

    Jason H. T. Bates & Gilman B. Allen

  2. HSRF 228, 149 Beaumont Avenue, Burlington, VT, 05405-0075, USA

    Jason H. T. Bates

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  1. Jason H. T. Bates
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  2. Gilman B. Allen
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Correspondence to Jason H. T. Bates.

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Bates, J.H.T., Allen, G.B. The Estimation of Lung Mechanics Parameters in the Presence of Pathology: A Theoretical Analysis. Ann Biomed Eng 34, 384–392 (2006). https://doi.org/10.1007/s10439-005-9056-6

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  • DOI: https://doi.org/10.1007/s10439-005-9056-6

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