Abstract
The third Biomedical Imaging Research Opportunities Workshop (BIROW III) was held on March 11–12, 2005, in Bethesda, MD. The workshop addressed four areas of imaging that present opportunities for research and development: Multimodality Image-Guided Therapy, Imaging Informatics, Imaging Cell Trafficking, and Technology Improvement and Commercialization. The first three areas were individually addressed in their own plenary sessions, followed by audience discussions that explored research opportunities and challenges. This paper synthesizes these discussions into a strategy for future research directions in biomedical imaging.
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Ackerman, M. J., and T. S. Yoo. The Visible Human data sets (VHD) and Insight Toolkit (ITk): Experiments in open source software. AMIA Annu. Symp. Proc. 773, 2003.
Arbab, A. S., G. T. Yocum, L. B. Wilson, A. Parwana, E. K. Jordan, H. Kalish, and J. A. Frank. Comparison of transfection agents in forming complexes with ferumoxides, cell labeling efficiency, and cellular viability. Mol. Imaging 3:24–32, 2004.
Barry, F. P. Mesenchymal stem cell therapy in joint disease. Novartis Found. Symp. 249:86–96; discussion 96-102, 170-104, 239-141, 2003.
Becknell, B., and M. A. Caligiuri. Cancer T cell therapy expands [comment]. Nat. Med. 9:257–258, 2003.
Cao, Y. A., A. J. Wagers, A. Beilhack, J. Dusich, M. H. Bachmann, R. S. Negrin, I. L. Weissman, and C. H. Contag. Shifting foci of hematopoiesis during reconstitution from single stem cells. Proc. Natl. Acad. Sci. U.S.A. 101:221–226, 2004.
Citardi, M. J., and P. S. Batra. Image-guided sinus surgery: Current concepts and technology. Otolaryngol. Clin. North Am. 38:439–452, 2005.
Coldwell, D. M., and P. E. Sewell. The expanding role of interventional radiology in the supportive care of the oncology patient from diagnosis to therapy. Semin. Oncol. 32:169–173, 2005.
Dayton, P. A., J. E. Chomas, A. F. Lum, J. S. Allen, J. R. Lindner, S. I. Simon, and K. W. Ferrara. Optical and acoustical dynamics of microbubble contrast agents inside neutrophils. Biophys. J. 80:1547–1556, 2001.
Ewers, R., K. Schicho, G. Undt, F. Wanschitz, M. Truppe, R. Seemann, and A. Wagner. Basic research and 12 years of clinical experience in computer-assisted navigation technology: A review. Int. J. Oral Maxillofac. Surg. 34:1–8, 2005.
Feleppa, E. J., C. R. Porter, and J. Ketterling, P. Lee, S. Dasgupta, S. Urban, and A. Kalisz. Recent developments in tissue-type imaging (TTI) for planning and monitoring treatment of prostate cancer. Utrason. Imaging 26:163–172, 2004.
Frank, J. A., S. A. Anderson, H. Kalsih, E. K. Jordan, B. K. Lewis, G. T. Yocum, and A. S. Arbab. Methods for magnetically labeling stem and other cells for detection by in vivo magnetic resonance imaging. Cytotherapy 6:621–625, 2004.
Gupta, S., and J. R. Chowdhury. Therapeutic potential of hepatocyte transplantation. Semin. Cell Dev. Biol. 13:439–446, 2002.
Hendee, W. R., and J. D. Bourland. Image-guided intervention. Acad. Radiol.10:896–900, 2003.
Hillman, B. J. The American College of Radiology Imaging Network (ACRIN): Research educational opportunities for academic radiology. Acad. Radiol. 9:561–562, 2002.
Huang, H. K. Medical imaging informatics research and development trends—An editorial. Comput. Med. Imaging Graph 29:91–93, 2005.
Humes, H. D., W. F. Weitzel, and R. H. Bartlett, et al. Renal cell therapy is associated with dynamic and individualized responses in patients with acute renal failure. Blood Purif. 21:64–71, 2003.
Jaffray, D. A., J. H. Siewerdsen, J. W. Wong, and A. A. Martinez. Flat-panel cone-beam computed tomography for image-guided radiation therapy. Int. J. Radiat. Oncol. Biol. Phys. 53:1337–1349, 2002.
Jones, E. A., M. H. Baron, S. E. Fraser, and M. E. Dickinson. Dynamic in vivo imaging of mammalian hematovascular development using whole embryo culture. Methods Mol. Med. 105:381–394, 2005.
Kahler, D. M. Image guidance: Fluoroscopic navigation. Clin. Orthop. Relat. Res. 421:70–76, 2004.
Kahn, C. E., Jr. Self-documenting structured reports using open information standards. Medinfo 9:403–407, 1998.
Kircher, M. F., U. Mahmood, R. S. King, R. Weissleder, and L. Josephson. In vivo high resolution three-dimensional imaging of antigen-specific cytotoxic T-lymphocyte trafficking to tumors. Cancer Res. 63:6838–6846, 2003.
Kulikowski, C. A. Medical imaging informatics: Challenges of definition and integration. J. Am. Med. Inform. Assoc. 4:252–253, 1997.
Kulikowski, C., E. Ammenwerth, and A. Bohne, et al. Medical Imaging Informatics and Medical Informatics: Opportunities and constraints. Findings from the IMIA yearbook of Medical Informatics 2002. Methods Inform. Med. 41:183–189, 2002.
Lindner, J. R., P. A. Dayton, M. P. Coggins, K. Ley, J. Song, K. Ferrara, and S. Kaul. Noninvasive imaging of inflammation by ultrasound detection of phagocytosed microbubbles. Circulation 102:531–538, 2000.
Mackie, T. R., J. Kapatoes, and K. Ruchala, et al. Image guidance for precise conformal radiotherapy. Int. J. Radiat. Oncol. Biol. Phys. 56:89–105, 2003.
Marienhagen, J., B. Hennemann, R. Andreesen, and C. Eilles. 111In-oxine labelling of tumour-cytotoxic macrophages generated in vitro from circulating blood monocytes: An in vitro evaluation. Nucl. Med. Commun. 16:357–361, 1995.
Mazzini, L., F. Fagioli, and R. Boccaletti, et al. Stem cell therapy in amyotrophic lateral sclerosis: A methodological approach in humans. Amyotroph. Lateral Scler. Other Motor Neuron Disord. 4:158–161, 2003.
McDonald, J. W. Repairing the damaged spinal cord: From stem cells to activity-based restoration therapies. Clin. Neurosurg. 51:207–227, 2004.
Pankratov, Y. V., A. I. Ivanov, T. D. Kolokoltsova, et al. Cell-based therapy of chronic degenerative diseases of the central nervous system. Adv. Exp. Med. Biol. 534:97–105, 2003.
Paulmurugan, R., Y. Umezawa, and S. S. Gambhir. Ex vivo cell labeling with 64Cu-pyruvaldehyde-bis(N4- methylthiosemicarbazone) for imaging cell trafficking in mice with positron-emission tomography. Proc. Natl. Acad. Sci. U.S.A. 99:3030–3035, 2002.
Peaire, A. E., T. Takeshima, J. M. Johnston, et al. Production of dopaminergic neurons for cell therapy in the treatment of Parkinson's disease. J. Neurosci. Methods 124:61–74, 2003.
Ponchietti, R., G. Martorana, F. Di Loro, et al. A novel spectral ultrasonic differentiation method for marking regions of interest in biological tissue: In vitro results for prostate. Arch. Ital. Urol. Androl. 76:147–153, 2004.
Scharfmann, R. Alternative sources of beta cells for cell therapy of diabetes. Eur. J. Clin. Invest. 33:595–600, 2003.
Schellingerhout, D., and L. Josephson. Molecular imaging of cell-based therapies. Neuroimaging Clin. North Am. 14:331–342, 2004.
Schwartz, Y., and R. Kornowski. Autologous stem cells for functional myocardial repair. Heart Fail. Rev. 8:237–245, 2003.
van den Bos, E. J., A. Wagner, H. Mahrholdt, R. B. Thompson, Y. Morimoto, B. S. Sutton, R. M. Judd, and D. A. Taylor. Improved efficacy of stem cell labeling for magnetic resonance imaging studies by the use of cationic liposomes. Cell Transplant. 12:743–756, 2003.
Vosburgh, K. G., and F. A. Jolesz. The concept of image-guided therapy. Acad. Radiol. 10:176–179, 2003.
Wang, G., and M. D. Wang. Development of a biomedical imaging informatics system for diagnosis and treatment planning. AMIA Annu. Symp. Proc. 1045, 2003.
Zerhouni, E. Medicine. The NIH Roadmap. Science 302:63–72, 2003.
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Hendee, W.R., Gazelle, G.S. Biomedical Imaging Research Opportunities Workshop III: A White Paper. Ann Biomed Eng 34, 188–198 (2006). https://doi.org/10.1007/s10439-005-9040-1
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DOI: https://doi.org/10.1007/s10439-005-9040-1