Acta Mechanica Sinica

, Volume 33, Issue 2, pp 243–249 | Cite as

Effects of adenosine triphosphate concentration on motor force regulation during skeletal muscle contraction

Research Paper

Abstract

We employ a mechanical model of sarcomere to quantitatively investigate how adenosine triphosphate (ATP) concentration affects motor force regulation during skeletal muscle contraction. Our simulation indicates that there can be negative cross-bridges resisting contraction within the sarcomere and higher ATP concentration would decrease the resistance force from negative cross-bridges by promoting their timely detachment. It is revealed that the motor force is well regulated only when ATP concentration is above a certain level. These predictions may provide insights into the role of ATP in regulating coordination among multiple motors.

Keywords

Motor force regulation ATP Muscle contraction Myosin 

Notes

Acknowledgements

The project was supported by the National Natural Science Foundation of China (Grants 11372279, 11572285).

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Copyright information

© The Chinese Society of Theoretical and Applied Mechanics; Institute of Mechanics, Chinese Academy of Sciences and Springer-Verlag Berlin Heidelberg 2017

Authors and Affiliations

  1. 1.Department of Engineering MechanicsZhejiang UniversityHangzhouChina

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