Effects of adenosine triphosphate concentration on motor force regulation during skeletal muscle contraction
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We employ a mechanical model of sarcomere to quantitatively investigate how adenosine triphosphate (ATP) concentration affects motor force regulation during skeletal muscle contraction. Our simulation indicates that there can be negative cross-bridges resisting contraction within the sarcomere and higher ATP concentration would decrease the resistance force from negative cross-bridges by promoting their timely detachment. It is revealed that the motor force is well regulated only when ATP concentration is above a certain level. These predictions may provide insights into the role of ATP in regulating coordination among multiple motors.
KeywordsMotor force regulation ATP Muscle contraction Myosin
The project was supported by the National Natural Science Foundation of China (Grants 11372279, 11572285).
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