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Roflumilast zur Behandlung von Exazerbationen bei Patienten mit schwerer COPD

Roflumilast in the treatment of patients with exacerbations of severe COPD

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Literatur

  1. Calverley PM et al (2015) Effect of roflumilast on exacerbations in patients with severe chronic obstructive pulmonary disease uncontrolled by combination therapy (REACT): a multicentre randomised controlled trial. Lancet 385(9971):857–866

  2. De Backer W et al (2014) The effect of roflumilast in addition to LABA/LAMA/ICS treatment in COPD patients. Eur Respir J 44(2):527–529

    Article  PubMed  Google Scholar 

  3. Fabbri LM et al (2009) Roflumilast in moderate-to-severe chronic obstructive pulmonary disease treated with longacting bronchodilators: two randomised clinical trials. Lancet 374(9691):695–703

    Article  CAS  PubMed  Google Scholar 

  4. Magnussen H et al (2014) Withdrawal of inhaled glucocorticoids and exacerbations of COPD. N Engl J Med 371(14):1285–1294

    Article  PubMed  Google Scholar 

  5. Martinez FJ et al (2015) Effect of roflumilast on exacerbations in patients with severe chronic obstructive pulmonary disease uncontrolled by combination therapy (REACT): a multicentre randomised controlled trial. Lancet 385(9971):857–866

    Article  CAS  PubMed  Google Scholar 

  6. O’Reilly J et al (2010) Management of stable chronic obstructive pulmonary disease in primary and secondary care: summary of updated NICE guidance. BMJ 340:c3134

    Article  PubMed  Google Scholar 

  7. Rabe KF (2011) Update on roflumilast, a phosphodiesterase 4 inhibitor for the treatment of chronic obstructive pulmonary disease. Br J Pharmacol 163(1):53–67

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Rennard SI et al (2011) Reduction of exacerbations by the PDE4 inhibitor roflumilast – the importance of defining different subsets of patients with COPD. Respir Res 12:18

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Suissa S et al (2013) Inhaled corticosteroids in COPD and the risk of serious pneumonia. Thorax 68(11):1029–1036

    Article  PubMed  PubMed Central  Google Scholar 

  10. Vestbo J et al (2013) Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am J Respir Crit Care Med 187(4):347–365

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. POIS Leipzig GbR. PD Dr. med Christian Gessner/Steffi Gessner. Pneumologisch/onkologisch/internistisches Studienzentrum, Tauchaer Str. 12, 04357, Leipzig, Deutschland

    C. Gessner

  2. Universitätsklinik für Pneumologie, Otto-von-Guericke-Universität Magdeburg, Magdeburg, Deutschland

    J. Schreiber

  3. Abteilung Pneumologie, Universitätsklinikum Leipzig, Leipzig, Deutschland

    C. Gessner

Authors
  1. C. Gessner
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  2. J. Schreiber
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Corresponding author

Correspondence to C. Gessner.

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C. Gessner und J. Schreiber geben an, dass kein Interessenkonflikt besteht.

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Redaktion

J. Schreiber, Magdeburg

P. Zabel, Lübeck/Borstel

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Gessner, C., Schreiber, J. Roflumilast zur Behandlung von Exazerbationen bei Patienten mit schwerer COPD. Pneumologe 13, 255–257 (2016). https://doi.org/10.1007/s10405-016-0049-y

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  • DOI: https://doi.org/10.1007/s10405-016-0049-y

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