Skip to main content
Log in

Hämoptysen

Hemoptysis

  • Leitthema
  • Published:
Der Pneumologe Aims and scope

Zusammenfassung

Hämoptysen sind potenziell lebensbedrohliche Komplikationen unterschiedlichster Krankheiten. Häufigste Ursachen sind entzündliche und infektiöse Erkrankungen, gefolgt von Neoplasmen, Lungenembolien, Herzklappenfehlern, Gerinnungsstörungen und zahlreichen Systemerkrankungen. Routineuntersuchungen sind: Thoraxröntgenbild, (Angio-)CT und Bronchoskopie sowie evtl. eine Kontrastdarstellung der Bronchialarterien. Gefährdet ist der Patient durch Verschlüsse der Atemwege mit Koageln. Die wichtigsten Maßnahmen bei Hämoptoe sind daher Sauerstoffgabe, Lagerung auf die blutende Seite, bronchoskopische Absaugung von Blut und Gerinnseln. Gerinnungsstörungen müssen ausgeglichen werden. Kurzfristig helfen vasokonstriktive Medikamente. Bei zentralen Prozessen kann man über das Bronchoskop mit dem Argon-Plasma-Beamer oder dem Laser koagulieren. Bei schweren Blutungen aus der Peripherie muss eine Ballon- oder Tubustamponade durchgeführt werden. Je nach Ursache und Schweregrad der Hämoptoe folgt eine antientzündliche Behandlung, eine hämostyptische Strahlentherapie, eine Bronchialarterienembolisation oder eine Operation.

Abstract

Hemoptysis is a potentially life-threatening complication of various diseases. The most common causes are infectious and inflammatory processes, followed by neoplasms, pulmonary embolisms, mitral stenoses, coagulopathies, and multiple systemic disorders. Primary examinations include chest X-ray, angio CT, and bronchoscopy. Sometimes, a bronchial artery angiogram is required. The patient is at risk of suffocation because blood and clots can severely obstruct his airways. Thus, the most important measures are supplemental oxygen, positioning the patient with the bleeding side down, bronchoscopic suctioning, and removal of blood and clots. Coagulopathies have to be corrected. Application of vasoactive drugs may help temporarily. In cases of bleeding from central lesions, coagulation with laser or argon plasma coagulator is feasible. Heavy bleeding from the periphery requires a balloon or tube tamponade. Depending on the cause and the severity of the bleeding anti-inflammatory medical treatment, hemostyptic radiation therapy, bronchial artery embolization, or a surgical procedure must follow.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Abb. 1a, b
Abb. 2
Abb. 3a, b
Abb. 4a–c
Abb. 5a, b

Literatur

  1. Abal AT, Nair PC, Cherian J (2001) Haemoptysis: aetiology, evaluation and outcome – a prospective study in a third-world country. Respir Med 95: 548–552

    Article  PubMed  Google Scholar 

  2. Ackerman MJH, Warakarn V, Jirasakuldech B (2002) Intralesional epinephrine injection for bleeding endobronchial tumor. J Bronchol 9: 19–21

    Article  Google Scholar 

  3. Antonelli M, Midulla F, Tancredi G et al. (2002) Bronchial artery embolization for the management of nonmassive cystic fibrosis. Chest 121: 796–801

    Article  PubMed  Google Scholar 

  4. Arney KL, Judson MA, Sahn SA (1999) Airway obstruction arising from blood clot: three reports and review of the literature. Chest 115: 293–300

    Article  PubMed  Google Scholar 

  5. Ayed A (2003) Pulmonary resection for massive hemoptysis of benign etiology. Eur J Cardiothorac Surg 24: 689–693

    Article  PubMed  Google Scholar 

  6. Bernard A, Ciallot D, Couaillier JF et al. (1997) Surgical management of invasive pulmonary aspergillosis in neutropenic patients. Ann Thorac Surg 64: 1441–1447

    Article  PubMed  Google Scholar 

  7. Botnick W, Brown H (1994) Endobronchial urokinase for dissolution of massive clot following transbronchial biopsy. Chest 105: 953–954

    PubMed  Google Scholar 

  8. Conlan AA, Hurwitz SS, Krige L et al. (1983) Massive hemoptysis. Review of 123 cases. J Thorac Cardiovasc Surg 85: 120–124

    PubMed  Google Scholar 

  9. Crocco JA, Rooney JJ, Fankushen DS (1968) Massive hemoptysis. Arch Intern Med 121: 495–498

    Article  PubMed  Google Scholar 

  10. Endo S, Otani S, Saito N et al. (2003) Management of massive hemoptysis in a thoracic surgical unit. Eur J Cardiothorac Surg 23: 467–472

    Article  PubMed  Google Scholar 

  11. Freitag L, Tekolf E, Stamatis G et al. (1994) Three years experience with a new balloon catheterfor the management of hemoptysis. Eur Resp J 7: 2033–2037

    Google Scholar 

  12. Fujimoto T, Hillejahn L, Stamatis G (2001) Current strategy for surgical management of bronchiectasis. Ann Thorac Surg 72: 1711–1715

    Article  PubMed  Google Scholar 

  13. Gerasin VA, Shafirovsky BB (1988) Endobronchial electrosurgery. Chest 93: 270–274

    PubMed  Google Scholar 

  14. Håkanson E, Konstantinov IE, Fransson SG, Svedjeholm R (2002) Management of life-threatening haemoptysis. Br J Anaesthesia 88: 291–295

    Article  Google Scholar 

  15. Haponik EF, Fein A, Chin R (2000) Managing life-threatening hemoptysis. Has anything really changed? Chest 118: 1431–1435

    Article  PubMed  Google Scholar 

  16. Herth FJF, Ernst A, Becker HD (2001) Longterm outcome and lung cancer incidence in patients with hemoptysis of unknown origin. Chest 120(5): 1592–1594

    Article  PubMed  Google Scholar 

  17. Jean-Baptiste E (2000) Clinical assessment and management of massive hemoptysis. Crit Care Med 28: 1642–1647

    Article  PubMed  Google Scholar 

  18. Jones DK, Cavanagh P, Sheerson JM, Flower CDR (1985) Does bronchography have a role in the assessment of patients with haemoptysis? Thorax 40: 668–670

    PubMed  Google Scholar 

  19. Jougon J, Ballester M, Delcambre F et al. (2002) Massive hemoptysis: what place for medical and surgical treatment. Eur J Cardiothorac Surg 22: 345–351

    Article  PubMed  Google Scholar 

  20. Kallay N, Dunagan DP, Adair N et al. (2001) Hemoptysis in patients with renal insufficiency. The role of flexible bronchoscopy. Chest 119: 788–794

    Article  PubMed  Google Scholar 

  21. Knott-Craig CJ, Oostuizen JG, Rossouw G et al. (1993) Management and prognosis of massive hemoptysis. Recent experience with 120 patients. J Thorac Cardiovasc Surg 105: 394–397

    PubMed  Google Scholar 

  22. Lordan JL, Gascoigne A, Corris PA (2003) The pulmonary physician in critical care. Illustrive case 7: Assessment and management of massive haemoptysis. Thorax 58: 814–819

    Article  PubMed  Google Scholar 

  23. Mal H, Rullon I, Mellot F et al. (1999) Immediate and long-term results of bronchial artery embolization for life-threatening hemoptysis. Chest 115: 996–1001

    Article  PubMed  Google Scholar 

  24. Ong TH, Eng P (2003) Massive hemoptysis requiring intensive care. Intensive Care Med 29: 317–320

    PubMed  Google Scholar 

  25. Osaki S, Nakanishi Y, Wataya H et al. (2000) Prognosis of bronchial artery embolization in the management of hemoptysis. Respiration 67: 412–416

    Article  PubMed  Google Scholar 

  26. Prakash UBS, Freitag L (1994) Hemoptysis and bronchoscopy induced hemorrhage. In: Prakash USB (ed) Bronchoscopy. Raven, New York, pp 227–251

  27. Ramon P, Wallaert B, Derollez M et al. (1989) Treatment of severe hemoptysis with terlipressin. Study of the efficacy and tolerance of this product. Rev Mal Respir 6: 365–368

    PubMed  Google Scholar 

  28. Reichle G, Freitag L, Kullmann HJ et al. (2000) Erfahrungen mit der Argon-Plasma-Koagulation in der Bronchologie. Bericht über Erfahrungen bei 482 Anwendungen. Pneumologie 54: 508–516

    Article  PubMed  Google Scholar 

  29. Sahn JJ (1996) Thoracic endometriosis syndrome: new observations from an analysis of 110 cases. Am J Med 100: 164–167

    Article  PubMed  Google Scholar 

  30. Saw EC, Gottlieb LS,Yokoyama T, Lee BC (1976) Flexible fiberoptic bronchoscopy and endobronchial tamponade in the management of massive hemoptysis. Chest 70: 589–591

    PubMed  Google Scholar 

  31. Sidman JD, Wheeler WB, Cabalka AK et al. (2001) Management of acute pulmonary hemorrhage in children. Laryngoscope 111: 33–35

    Article  PubMed  Google Scholar 

  32. Speiser BL, Spratling L (1993) Remote afterloading brachytherapy for the local control of endobronchial carcinoma. Int J Radiation Oncol Biol Phys 25: 579–587

    Google Scholar 

  33. Thompson AB, Teschler H, Rennard SI (1992) Pathogenesis, evaluation, and therapy for massive hemoptysis. Clin Chest Med 13: 69–82

    PubMed  Google Scholar 

  34. Tsukamoto T, Sasaki H, Nakamura H (1989) Treatment of hemoptysis patients by thrombin and fibrinogenthrombin infusion therapy using a fiberoptic bronchoscope. Chest 48: 272–274

    Google Scholar 

  35. Uziel Y, Laxer RM, Siverman ED (1997) Persistent pulmonary hemorrhage as the sole initial clinical manifestation of pediatric systemic lupus erythematosus. Clin Exp Rheumatol 15: 697–700

    PubMed  Google Scholar 

  36. Valipour A, Kreuzer A, Koller H et al. (2005) Bronchoscopy-guided topical hemostatic tamponade therapy for the management of life-threatening hemoptysis. Chest 127(6): 2113–2118

    Article  PubMed  Google Scholar 

  37. Wong ML, Szkup P, Hopley MJ (2002) Percutaneous embolotherapy for life-threatening hemoptysis. Chest 121: 95–102

    Article  PubMed  Google Scholar 

  38. Savage R (2002) Prone position as a life saving measure for acute pulmonary haemorrhage in a young adult with cystic fibrosis. Anaesth Intensive Care 30: 223–225

    PubMed  Google Scholar 

  39. Wong ML, Szkup P, Hopley MJ (2002) Percutaneous embolotherapy for life-threatening hemoptysis. Chest 121: 95–102

    Article  PubMed  Google Scholar 

  40. Zavala MC (1978) Pulmonary hemorrhage in fiberoptic transbronchial biopsy. Chest 70: 384–388

    Google Scholar 

Download references

Interessenkonflikt

Keine Angaben

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to F. Herth.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Herth, F., Eberhardt, R. & Freitag, L. Hämoptysen. Pneumologe 3, 188–196 (2006). https://doi.org/10.1007/s10405-006-0095-y

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10405-006-0095-y

Schüsselwörter

Keywords

Navigation