Zusammenfassung
Die chronisch obstruktive Lungenerkrankung („chronic obstructive pulmonary disease“, COPD) gehört neben Asthma bronchiale zu den sozioökonomisch bedeutsamsten Lungenerkrankungen. Trotz dieser sozioökonomischen Bedeutung und der hohen Prävalenz gibt es noch immer eine Vielzahl ungeklärter Fragen bezüglich Pathogenese und Pathophysiologie. Diesbezüglich konnten wesentliche neue Erkenntnisse in jüngsten Arbeiten gewonnen werden. Die vorliegende Analyse bietet eine Zusammenfassung dieser Erkenntnisse und unterscheidet dabei tierexperimentelle und präklinische humane Studien zur Pathophysiologie der Erkrankung.
Abstract
Chronic obstructive pulmonary disease (COPD) is, next to bronchial asthma, one of the most important socioeconomic pulmonary diseases. Despite its global importance, there is still a major lack of knowledge on the pathogenesis and pathophysiology of the disease, even though numerous recent studies have elucidated some important mechanisms. The present analysis is a summary of relevant findings and differentiates between animal experimental and preclinical human studies addressing important pathophysiologic features of COPD.
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Groneberg, D.A., Welte, T. Pathophysiologie der chronisch obstruktiven Lungenerkrankung. Pneumologe 3, 89–97 (2006). https://doi.org/10.1007/s10405-005-0078-4
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DOI: https://doi.org/10.1007/s10405-005-0078-4