Zusammenfassung
Neue Ansätze zur Behandlung des nichtkleinzelligen Bronchialkarzinoms außerhalb von Chemotherapie, Strahlentherapie und Operation sind momentan nicht zu erwarten. Für die Verfahrenwahl ist das exakte prätherapeutische Staging der entscheidende Faktor. Eines seiner wesentlichen Ziele ist die Unterscheidung zwischen potenziell resezierbaren und nichtresezierbaren Tumoren. Die chirurgisch-diagnostischen Verfahren [Mediastinoskopie, videoassistierte Thorakoskopie (VATS), offen-chirurgisch Verfahren] sind für die T-, N- und M-Stadien etabliert. Eingebunden in einen sinnvollen Algorithmus vervollständigen sie die radiologischen und neueren, mit endoluminalem Ultraschall ergänzten, endoskopischen Untersuchungsverfahren für ein möglichst exaktes prätherapeutisches Tumorstaging.
Abstract
In the absence of any substantial new breakthroughs in the treatment of lung cancer, precise tumour staging becomes the most important single treatment factor in each case. Staging lung cancer determines the extent of disease and stratifies patients into similar therapeutic and prognostic categories. One of the primary goals of staging is to separate patients with potential resectable disease from those with diseases that are unresectable. Therefore, surgical diagnostic tools [different methods of mediastinoscopy, video-assisted thoracic surgery (VATS) and open approaches] are established for every part of the TNM classification. Integrated in a diagnostic algorithm surgical methods complete the different radiological and the newer endoscopic techniques for the most doable exact pretherapeutic tumour stage.
Literatur
Blanc FX, Atassi K, Bignon J et al. (2002) Diagnostic value of medical thoracoscopy in pleural disease: a 6-year retrospective study. Chest 121: 1677
Brega-Massone PP, Conti B, Magnani B et al. (2004) Minimally invasive thoracic surgery for diagnostic assessment and palliative treatment in recurrent neoplastic pleural effusion. Thorac Cardiovasc Surg 52: 191
Burdine J, Joyce LD, Plunkett MB et al. (2002) Feasibility and value of video-assisted thoracoscopic surgery wedge excision of small pulmonary nodules in patients with malignancy. Chest 122: 1467
Carlens E (1959) Mediastinoscopy: a method for inspection and tissue biopsy of the superior mediastinum. Chest 36: 343
Daniels AC (1949) Method of biopsy useful diagnostic in diagnosing intrathoracic diseases. Dis Chest 16: 360
Dienemann H, Hoffmann H (2003) Endoscopic thoracic surgery: indications, feasibility, and limitations. Chirurg 74: 324
Ginsberg RJ (1987) Evaluation of mediastinum by invasive techniques. Surg Clin North Am 67: 1025
Ginsberg RJ, Rice TW, Goldberg M et al. (1987) Extended cervical mediastinoscopy: a single staging procedure for bronchogenic carcinoma of the left upper lobe. J Thorac Cardiovasc Surg 94: 673
Gonzalez-Stawinski GV (2003) A comparative analysis of positron emission tomography and mediastinoscopy in staging non-small cell lung cancer. J Thorac Cardiovasc Surg 6: 1900
Gossot D, Toledo L, Fritsch S et al. (1996) Mediastinoscopy vs. thoracoscopy for mediastinal biopsy. Results of a prospective non-randomized study. Chest 110: 1328
Greis M, Atay Z (1990) Cytomorphologic concomitant reactions in malignant pleural effusions. Pneumologie 44: 263
Hoffmann H (2001) Invasive staging of lung cancer by mediastinoscopy and video-assisted thoracoscopy. Lung Cancer 34: 3
Herth F, Becker HD, Ernst A (2004) Conventional vs endobronchial ultrasound-guided transbronchial needle aspiration: a randomized trial. Chest 125: 322
Jarvi OH, Kunnas RJ, Laitio MT (1972) The accuracy and significance of cytologic cancer diagnosis in pleural effusion. Acta Cytol 16: 152
Jolly PC, Hill LD, Lawless PA et al. (1973) Parasternal mediastinotomy and mediastinoscopy. Adjuncts in the diagnosis of chest disease. J Thorac Cardiovasc Surg 66: 549
Kirby TJ, Ginsberg RJ (1990) Role of thoracostomy in unknown pleural effusion. In: Delarue NC, Eschapasse H (eds) Thoracic surgery. Surgical management of pleural diseases. In: Deslauries J, Lacquet LK (eds) International trends in general thoracic surgery, vol 6. Mosby, St Louis, p 2
Kirby TJ, Stanley CF (2002) Mediastinoscopy. In: Pearson FG, Cooper JD, Deslausiers J (eds) Thoracic surgery, 2nd edn. Churchill Livingstone, Philadelphia
Light RW, Erozan YS, Ball WC (1973) Cells in pleural fluid. Their value in differential diagnosis. Arch Intern Med 132: 854
McNeill TM, Chamberlain JM (1966) Diagnostic anterior mediastinotomy. Ann Thorac Surg 2: 532
Menzies R, Charbonneau B (1991) Thoracoscopy for the diagnosis of pleural diseases. Ann Intern Med 114: 271
Mountain CF, Dresler CM (1997) Regional lymph node classification for lung cancer staging. Chest 111: 1718
Pearson FG (1965) Mediastinoscopy: a method of biopsy in the superior mediastinum. J Thorac Cardiovasc Surg 49: 11
Puhakka H (1989) Complications of mediastinoscopy. J Larnygol Otol 103: 312
Rendina EA, Vinata F, DeGiacomo T et al. (1994) Comparative merrits of thoracoscopy, mediastinoscopy and mediastinotomy for mediastinal biopsy. Ann Thorac Surg 57: 992
Venissac N, Alifano M, Mouroux J (2003) Video-assisted mediastinoscopy: experience from 240 consecutive cases. Ann Thorac Surg 76: 208
Interessenkonflikt:
Der korrespondierende Autor versichert, dass keine Verbindungen mit einer Firma, deren Produkt in dem Artikel genannt ist, oder einer Firma, die ein Konkurrenzprodukt vertreibt, bestehen.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Hecker, E. Bronchialkarzinom. Pneumologe 2, 92–101 (2005). https://doi.org/10.1007/s10405-005-0035-2
Issue Date:
DOI: https://doi.org/10.1007/s10405-005-0035-2
Schlüsselwörter
- Bronchialkarzinom
- Chirurgisch-diagnostische Verfahren
- Mediastinoskopie
- Videoassistierte Thorakoskopie (VATS)
- Chirurgisches Staging