Abstract
Acoustic wave-based manipulation of cells and particles in microfluidic channels has gained wide popularity in the past decade since it provides label-free and contact-less manipulation of them in a microfluidic environment using a very simple microfluidic structure and experimental setup. In bulk acoustofluidics, an acoustic resonance field that generates an acoustic standing wave within a microfluidic channel creates acoustic pressure nodes and anti-nodes, to which particles migrate to or migrate away from. However, in a given straight microfluidic channel, the position of the acoustic pressure nodes and anti-nodes are fixed and cannot be changed along the channel, limiting more diverse capabilities in moving particles and cells to a desired location within a microfluidic channel. Here, an acoustic echo-channel where its width changes along the flow direction was created right next to the main flow channel separated by a thin wall that minimizes the disturbance of the acoustic wave. This allows the location of the acoustic pressure nodes and anti-nodes to be controlled in the main flow channel depending on the width of the echo-channel, hence providing more flexibility in manipulating particles and cells to a certain position within a given microfluidic channel. The capability to more freely manipulate particles and cells within a microfluidic channel further expands the application areas of bulk acoustofluidics.
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Acknowledgement
Sinan Yigit was supported by the Ministry of National Education of the Republic of Turkey. This work was also partially supported by the the National Research Foundation of Korea (NRF) Grant funded by the Korean government (No. NRF-2017R1D1A1B03029817).
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Yigit, S., Wang, H., Han, SI. et al. Acoustofluidic microdevice for precise control of pressure nodal positions. Microfluid Nanofluid 24, 52 (2020). https://doi.org/10.1007/s10404-020-02356-0
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DOI: https://doi.org/10.1007/s10404-020-02356-0