A multilayer lateral-flow microfluidic device for particle separation

Jiang, Youwei; Yu, Zhenming; Huang, Xinglong; Chen, Rifei; Chen, Weiyuan; Zeng, Yifan; Xu, Chengqi; Min, Haodi; Zheng, Nan; Cheng, Xing

doi:10.1007/s10404-018-2053-5

Research Paper
Published: 16 March 2018

A multilayer lateral-flow microfluidic device for particle separation

Youwei Jiang ORCID: orcid.org/0000-0002-0142-322X¹^na1,
Zhenming Yu¹^na1,
Xinglong Huang¹,
Rifei Chen¹,
Weiyuan Chen¹,
Yifan Zeng¹,
Chengqi Xu¹,
Haodi Min¹,
Nan Zheng¹ &
Xing Cheng¹

Microfluidics and Nanofluidics volume 22, Article number: 40 (2018) Cite this article

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Abstract

Particle separation technology plays an important role in a wide range of applications as a critical sample preprocessing step for analysis. In this work, we proposed and fabricated a multilayer lateral-flow particle filtration and separation device based on polydimethylsiloxane molding and transfer bonding techniques. Particle separation capability was demonstrated by 4.5-um polystyrene bead filtration and cancer cell (SK-BR-3) retrieving. This device exhibits higher throughput compared with most active particle separation methods and is less vulnerable to membrane clogging problem. This novel multilayer particle filtration and separation device is expected to find applications in biomedical, environmental and microanalysis fields.

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Acknowledgements

This work was partially funded by the Shenzhen Science and Technology Innovation Committee for basic science (Grant No. JCYJ20160301114303878 and JCYJ20160530184718406) and Pearl River Talents Recruitment Program (No. 2016ZT06G587). The authors also thank the support from the National Young Thousand Talent Program.

Author information

Youwei Jiang and Zhenming Yu have contributed equally to this work.

Authors and Affiliations

Shenzhen Key Laboratory for Nanoimprint Technology, Department of Materials Science and Engineering, Southern University of Science and Technology, No 1088, Xueyuan Rd, Xili, Nanshan District, Shenzhen, 518055, Guangdong, China
Youwei Jiang, Zhenming Yu, Xinglong Huang, Rifei Chen, Weiyuan Chen, Yifan Zeng, Chengqi Xu, Haodi Min, Nan Zheng & Xing Cheng

Authors

Youwei Jiang
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Zhenming Yu
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Xinglong Huang
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Rifei Chen
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Weiyuan Chen
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Yifan Zeng
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Chengqi Xu
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Haodi Min
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Nan Zheng
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Xing Cheng
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Corresponding author

Correspondence to Xing Cheng.

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Cite this article

Jiang, Y., Yu, Z., Huang, X. et al. A multilayer lateral-flow microfluidic device for particle separation. Microfluid Nanofluid 22, 40 (2018). https://doi.org/10.1007/s10404-018-2053-5

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Received: 15 November 2017
Accepted: 28 February 2018
Published: 16 March 2018
DOI: https://doi.org/10.1007/s10404-018-2053-5

Keywords

Microfluidics
Particle separation
Lateral-flow microfilter
Multilayer PDMS device