Abstract
Electrofluidic analogy is useful because it provides a method to significantly reduce the reliance of microfluidic chips on dynamic off-chip controllers. Among the functions developed by the analogy, conversion from constant to pulsatile pressure is critical and is yet to be studied. Here, unlike its counterpart electrical oscillator generating square pulses more slowly with decreasing the input voltage, we report that a microfluidic oscillator generates sawtooth pressure pulses more rapidly with decreasing the input pressure (PI) at 1–2 kPa. Further, with decreasing PI, the oscillator generates square pulses at PI > 3.4 kPa, but its operation unexpectedly stops at 2.1 < PI < 3.4 kPa. We analyze its underlying mechanism with a sophisticated model including a dynamic interaction of the oscillator components and reveal the critical role of the dynamic property of oscillator valves. Additionally, we show electrofluidic switching of a photodiode with the oscillator. The understanding obtained in this study would be essential for developing microfluidic circuits using electrofluidic analogy.
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References
Ahrar S, Hwang M, Duncan PN, Hui EE (2014) Microfluidic serial dilution ladder. Analyst 139:187–190
Dang VB, Kim S-J (2017) Water-head-driven microfluidic oscillators for autonomous control of periodic flows and generation of aqueous two-phase system droplets. Lab Chip 17:286–292
Dang VB, Kim S-J (2017) Modular fluidic resistors to enable widely tunable flow rate and fluidic switching period in a microfluidic oscillator. Electrophoresis 38(7):977–982
Dhakar L (2017) Overview of energy harvesting technologies. Triboelectric devices for power generation and self-powered sensing applications, 1st edn. Springer, Singapore, pp 9–37
Frank P, Gräfe D, Probst C, Haefner S, Elstner M, Appelhans D, Kohlheyer D, Voit B, Richter A (2017) Autonomous integrated microfluidic circuits for chip-level flow control utilizing chemofluidic transistors. Adv Funct Mater 27(30):1700430
Gomez-Sjoberg R, Leyrat AA, Pirone DM, Chen CS, Quake SR (2007) Versatile, fully automated, microfluidic cell culture system. Anal Chem 79(22):8557–8563
Grover WH, Skelley AM, Liu CN, Lagally ET, Mathies RA (2003) Monolithic membrane valves and diaphragm pumps for practical large-scale integration into glass microfluidic devices. Sens Actuators B 89(3):315–323
Grover WH, Ivester RHC, Jensen EC, Mathies RA (2006) Development and multiplexed control of latching pneumatic valves using microfluidic logical structures. Lab Chip 6:623–631
Jensen EC, Grover WH, Mathies RA (2007) Micropneumatic digital logic structures for integrated microdevice computation and control. J Microelectromech Syst 16(6):1378–1385
Kim S-J, Yokokawa R, Lesher-Perez SC, Takayama S (2012a) Constant flow-driven microfluidic oscillator for different duty cycles. Anal Chem 84(2):1152–1156
Kim S-J, Yokokawa R, Takayama S (2012b) Analyzing threshold pressure limitations in microfluidic transistors for self-regulated microfluidic circuits. Appl Phys Lett 101:234107
Kim S-J, Yokokawa R, Takayama S (2013) Microfluidic oscillators with widely tunable periods. Lab Chip 13:1644–1648
Kim S-J, Yokokawa R, Lesher-Perez SC, Takayama S (2015) Multiple independent autonomous hydraulic oscillators driven by a common gravity head. Nat Commun 6:7301
Kim C, Hwang DH, Lee S, Kim S-J (2016) Water-head pumps provide precise and fast microfluidic pumping and switching versus syringe pumps. Microfluid Nanofluid 20:4
Lecault V, White AK, Singhal A, Hansen CL (2012) Microfluidic single cell analysis: from promise to practice. Curr Opin Chem Biol 16(3–4):381–390
Leslie DC, Easley CJ, Seker E, Karlinsey JM, Utz M, Begley MR, Landers JP (2009) Frequency-specific flow control in microfluidic circuits with passive elastomeric features. Nat Phys 5:231–235
Li Z, Kim S-J (2017) Pulsatile micromixing using water-head-driven microfluidic oscillators. Chem Eng J 313:1364–1369
Mosadegh B, Kuo CH, Tung YC, Torisawa YS, Bersano-Begey T, Tavana H, Takayama S (2010) Integrated elastomeric components for autonomous regulation of sequential and oscillatory flow switching in microfluidic devices. Nat Phys 6:433–437
Rhee M, Burns MA (2009) Microfluidic pneumatic logic circuits and digital pneumatic microprocessors for integrated microfluidic systems. Lab Chip 9:3131–3143
Shin J, Park H, Dang VB, Kim CW, Kim S-J (2015) Elastomeric microfluidic valve with low, constant opening threshold pressure. RSC Adv 5:23239–23245
Thorsen T, Maerkl SJ, Quake SR (2002) Microfluidic large-scale integration. Science 298(5593):580–584
Wang J, Fan HC, Behr B, Quake SR (2012) Genome-wide single-cell analysis of recombination activity and De Novo mutation rates in human sperm. Cell 150(2):402–412
Weaver JA, Melin J, Stark D, Quake SR, Horowitz MA (2010) Static control logic for microfluidic devices using pressure-gain valves. Nat Phys 6:218–223
Wu C, Bai B, Liu Y et al (2017) Random number generation with cosmic photons. Phys Rev Lett 118:140402
Zhang Q, Zhang M, Djeghlaf L, Bataille J, Gamby J, Haghiri-Gosnet AM, Pallandre A (2017) Logic digital fluidic in miniaturized functional devices: perspective to the next generation of microfluidic lab-on-chips. Electrophoresis 38(7):953–976
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This study was supported by Konkuk University in 2015.
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Van Dang, B., Kim, G. & Kim, SJ. Anomalous pulse change in gravity-driven microfluidic oscillator and its application to photodiode switching. Microfluid Nanofluid 22, 18 (2018). https://doi.org/10.1007/s10404-018-2038-4
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DOI: https://doi.org/10.1007/s10404-018-2038-4