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Engineering droplet navigation through tertiary-junction microchannels

  • M. Baig
  • S. Jain
  • S. Gupta
  • G. Vignesh
  • V. Singh
  • S. Kondaraju
  • S. GuptaEmail author
Research Paper

Abstract

We present an experimental and in silico investigation of path selection by a single droplet inside a tertiary-junction microchannel using oil-in-water as a model system. The droplet was generated at a T-junction inside a microfluidic chip, and its flow behavior as a function of droplet size, streamline position, viscosity, and Reynolds number (Re) of the continuous phase was studied downstream at a tertiary junction having perpendicular channels of uniform square cross section and internal fluidic resistance proportional to their lengths. Numerical studies were performed using the multicomponent lattice Boltzmann method. Both the experimental and numerical results showed good agreement and suggested that at higher Re equal to 3, the flow was dominated by inertial forces resulting in the droplets choosing a path based on their center position in the flow streamline. At lower Re of 0.3, the streamline-assisted path selection became viscous force-assisted above a critical droplet size. As the Re was further reduced to 0.03, or when the viscosity of the dispersed phase was increased, the critical droplet size for transition also decreased. This multivariate approach can in future be used to engineer sorting of cells, e.g., circulating tumor cells (CTCs) allowing early-stage detection of life-threatening diseases.

Keywords

Tertiary-junction Droplet microfluidics Droplet sorting Lattice-Boltzmann Path selection 

Notes

Acknowledgements

We thank the Asian Office of Aerospace Research and Development (AOARD, Grant No. FA2386-15-1-4031) for providing the necessary funds to carry out this research. We are grateful to Prof. Rajesh Khanna for helping with the tensiometer experiments. SK acknowledges his DST INSPIRE fellowship.

Supplementary material

10404_2016_1828_MOESM1_ESM.pdf (962 kb)
Supplementary material 1 (PDF 962 kb)

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Copyright information

© Springer-Verlag Berlin Heidelberg 2016

Authors and Affiliations

  • M. Baig
    • 1
  • S. Jain
    • 1
  • S. Gupta
    • 1
  • G. Vignesh
    • 1
  • V. Singh
    • 1
  • S. Kondaraju
    • 2
  • S. Gupta
    • 1
    Email author
  1. 1.Department of Chemical EngineeringIndian Institute of Technology DelhiHauz Khas, New DelhiIndia
  2. 2.School of Mechanical SciencesIndian Institute of Technology BhubaneswarBhubaneswarIndia

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