Microfluidics and Nanofluidics

, Volume 16, Issue 5, pp 907–920

Engineering living systems on chips: from cells to human on chips

Research Paper

DOI: 10.1007/s10404-014-1341-y

Cite this article as:
Sei, Y., Justus, K., LeDuc, P. et al. Microfluid Nanofluid (2014) 16: 907. doi:10.1007/s10404-014-1341-y

Abstract

Engineering living systems on chips is an emerging direction with a goal to mimic physiologically accurate biological functions that can be applied to a diversity of applications, such as reliable in vitro drug-screening systems for reducing the need for animal testing. Taking advantages of creative platforms from electromechanical systems technology and from advanced biomaterials to mimic 3D extracellular matrix, these approaches to recapitulating organ-level structures and functions may bring unprecedented benefits to clinical translation of nanomedicines in the pharmaceutical and biomedical industries and to advanced tissue engineering for regenerative medicine. In this review, we discuss recent progress on the engineering of living systems on chips and highlight advanced technologies that integrate a variety of physiological cues including mechanical, chemical, and electrical signals with precise spatiotemporal controls. We also discuss current challenges and future directions of these approaches, analyzing the benefits of continued research in this field.

Keywords

Biomimetic Microfluidics Organ-on-a-chip Tissue Engineering Control 

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.The George W. Woodruff School of Mechanical Engineering, Institute for Electronics and Nanotechnology, Parker H. Petit Institute for Bioengineering and BioscienceGeorgia Institute of TechnologyAtlantaUSA
  2. 2.Departments of Mechanical Engineering, Biomedical Engineering, Computational Biology, and Biological SciencesCarnegie Mellon UniversityPittsburghUSA

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