Abstract
Microfluidic technologies are gaining increasing importance due to their capability of manipulating fluids at the microscale that should allow to synthesize many products with surprisingly high yields and short reaction times. In the lab-on-chip field researchers have developed microfluidic apparatuses to provide special equipments for producing positron emission tomography (PET) radiopharmaceuticals in a quicker, safer, and more reliable way compared to traditional vessel-based approaches. In this paper, we have selected a number of polymeric materials, such as polydimethylsiloxane (PDMS), SU-8, and Teflon-like coatings deposited on PDMS or hard substrates, to be used for the fabrication of micro apparatuses for radiosynthesis. Their radioactivity resistance was investigated employing different setups and the results analyzed by atomic force microscopy (AFM), optical microscopy, and Fourier transform infrared spectroscopy (FT-IR). To evaluate undesired absorption effects in the investigated materials, the fluoride radioactive trapping inside microchannel was measured through autoradiography. We found out that polymeric materials such as SU-8 and Teflon coated on hard materials seem very appealing for fabricating microreactors for radiochemistry.
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References
Ametamey SM, Honer M, Schubiger PA (2008) Molecular imaging with PET. Chem Rev 108(5):1501–1516
Arakawa K, Ono K, Isshiki M, Mimura K, Uchikoshi M, Mori H (2007) Observation of the one-dimensional diffusion of nanometer-sized dislocation loops. Science 318:956–959
Bowden N, Huck WTS, Paul KE, Whitesides GM (1999) The controlled formation of ordered, sinusoidal structures by plasma oxidation of an elastomeric polymer. Appl Phys Lett 75(17):2557–2559
Brady F, Luthra SK, Gillies JM, Geffery NT (2005) US 2005/0226776 A1
Brun C, Fromm M, Berger F, Delobelle P, Takadoum J, Beche E, Chambaudet A, Jaffiol F (2003) Modifications of polypropylene surface properties by He + ion implantation. J Polym Sci B 41(11):1183–1191
Carlier J, Chuda K, Arscott S, Thomy V, Verbeke B, Coqueret X, Camart JC, Druon C, Tabourier P (2006) High pressure-resistant Su-8 microchannels for monolithic porous structure integration. J Micromech Microeng 16(10):2211–2219
Chen Q, Li G, Jin QH, Zhao JL, Ren QS, Xu YS (2007) A rapid and low-cost procedure for fabrication of glass microfluidic devices. J Microelectromech Syst 16:1193–1200
Choi WM, Park OO (2003) A soft-imprint technique for direct fabrication of submicron scale patterns using a surface-modified PDMS mold. Microelectron Eng 70(1):131–136
Datta A, Eom IY, Dhar A, Kuban P, Manor R, Ahmad I, Gangopadhyay S, Dallas T, Holtz M, Temkin F, Dasgupta PK (2003) Microfabrication and characterization of teflon AF-coated liquid core waveguide channels in silicon. IEEE Sens J 3(6):788–795
Elizarov AM (2009) Microreactors for radiopharmaceutical synthesis. Lab Chip 9(10):1326–1333
Elizarov AM, van Dam RM, Shin YS, Kolb HC, Padgett HC, Stout D, Shu J, Huang J, Daridon A, Heath JR (2010) Design and optimization of coin-shaped microreactor chips for pet radiopharmaceutical synthesis. J Nucl Med 51(2):282–287
Gillies JM, Prenant C, Chimon GN, Smethurst GJ, Perrie W, Hambletta I, Dekker B, Zweit J (2006) Microfluidic reactor for the radiosynthesis of PET radiotracers. Appl Radiat Isot 64(3):325–332
Lee CC, Sui GD, Elizarov A, Shu CYJ, Shin YS, Dooley AN, Huang J, Daridon A, Wyatt P, Stout D, Kolb HC, Witte ON, Satyamurthy N, Heath JR, Phelps ME, Quake SR, Tseng HR (2005) Multistep synthesis of a radiolabeled imaging probe using integrated microfluidics. Science 310(5755):1793–1796
Lu SY, Watts P, Chin FT, Hong J, Musachio JL, Briard E, Pike VW (2004) Syntheses of C-11- and F-18-labeled carboxylic esters within a hydrodynamically-driven micro-reactor. Lab Chip 4(6):523–525
Matsukawa Y, Zinkle SJ (2007) One-dimensional fast migration of vacancy clusters in metals. Science 318(5852):959–962
Miller PW, Long NJ, de Mello AJ, Vilar R, Audrain H, Bender D, Passchier J, Gee A (2007) Rapid multiphase carbonylation reactions by using a microtube reactor: applications in positron emission tomography C-11-radiolabeling. Angew Chem Int Ed 46(16):2875–2878
Padgett HC, Buchanan CR, Collier TL, Matteo JC, Alvord CW (2005) 2005/0232387 A1
Pascali G, Mazzone G, Saccomanni G, Manera C, Salvadori PA (2010) Microfluidic approach for fast labeling optimization and dose-on-demand implementation. Nucl Med Biol 37(5):547–555
Phelps ME (2000) Positron emission tomography provides molecular imaging of biological processes. Proc Natl Acad Sci USA 97(16):9226–9233
Steel CJ, O’Brien AT, Luthra SK, Brady F (2007) Automated pet radiosyntheses using microfluidic devices. J Labelled Comp Radiopharm 50(5–6):308–311
Wirth BD (2007) How does radiation damage materials? Science 318:923–924
Wu CW, Gong GC (2008) Fabrication of PDMS-based nitrite sensors using Teflon AF coating microchannels. IEEE Sens J 8(5–6):465–469
Zhou JW, Ellis AV, Voelcker NH (2010) Recent developments in PDMS surface modification for microfluidic devices. Electrophoresis 31(1):2–16
Acknowledgments
The authors acknowledge the EU project “ROC”, grant agreement no. 213803 for financial support and thank Dr. Panetta in IFC-CNR of Pisa for helpful discussion on the experimental setup.
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Zacheo, A., Arima, V., Pascali, G. et al. Radioactivity resistance evaluation of polymeric materials for application in radiopharmaceutical production at microscale. Microfluid Nanofluid 11, 35–44 (2011). https://doi.org/10.1007/s10404-011-0770-0
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DOI: https://doi.org/10.1007/s10404-011-0770-0