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Comparison of strain elastography and shear wave elastography in diagnosis of fibrosis in nonalcoholic fatty liver disease

  • Original Article–Gastroenterology
  • Published:
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Abstract

Purpose

To reveal the ability of S-Map strain elastography to diagnose fibrosis in nonalcoholic fatty liver disease (NAFLD) and to compare its diagnostic ability with that of shear wave elastography (SWE).

Methods

Participants were patients with NAFLD who were scheduled to undergo liver biopsy at our institution between 2015 and 2019. A GE Healthcare LOGIQ E9 ultrasound system was used. For S-Map, the right lobe of the liver was visualized in the section where the heartbeat was detected by right intercostal scanning, a 4 × 2-cm region of interest (ROI) was defined at 5 cm from the liver surface, and ROI strain images were acquired. Measurements were repeated six times, with the average taken as the S-Map value. Correlations of S-Map and SWE values with fibrosis stage determined by liver biopsy were analyzed using multiple comparisons. The diagnostic performance of S-Map for fibrosis staging was assessed using receiver operating characteristic curves.

Results

In total, 107 patients (65 men, 42 women; mean age 51 ± 14 years) were analyzed. The S-Map value by fibrosis stage was 34.4 ± 10.9 for F0, 32.9 ± 9.1 for F1, 29.5 ± 5.6 for F2, 26.7 ± 6.0 for F3, and 22.8 ± 4.19 for F4. By fibrosis stage, the SWE value was 1.27 ± 0.25 for F0, 1.39 ± 0.20 for F1, 1.59 ± 0.20 for F2, 1.64 ± 0.17 for F3, and 1.88 ± 0.19 for F4. The diagnostic performance of S-Map (measured by area under the curve) was 0.75 for F2, 0.80 for F3, and 0.85 for F4. The diagnostic performance of SWE (measured by area under the curve) was 0.88 for F2, 0.87 for F3, and 0.92 for F4.

Conclusion

S-Map strain elastography was inferior to SWE in terms of ability to diagnose fibrosis in NAFLD.

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Data availability

The datasets generated and/or analyzed during the current study are available from the corresponding author on reasonable request.

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Acknowledgements

We thank Shunichirou Tanigawa, Takuma Oguri, and Naohisa Kamiyama for providing advice on the S-Map strain elastography technique.

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Authors and Affiliations

  1. Division of Gastroenterology and Hepatology, Department of Internal Medicine (Omori), School of Medicine, Faculty of Medicine, Toho University, 6-11-1 Omori-Nishi, Ota-Ku, Tokyo, 143-8541, Japan

    Yu Ogino, Noritaka Wakui, Hidenari Nagai & Takahisa Matsuda

Authors
  1. Yu Ogino
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  2. Noritaka Wakui
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  3. Hidenari Nagai
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  4. Takahisa Matsuda
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Corresponding author

Correspondence to Noritaka Wakui.

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Conflict of interest

YO, NW, HN, and TM declare that they have no conflicts of interest.

Ethical approval

All the procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1964 and later versions. This study was approved by the Ethics Committee of Toho University Omori Medical Center.

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Ogino, Y., Wakui, N., Nagai, H. et al. Comparison of strain elastography and shear wave elastography in diagnosis of fibrosis in nonalcoholic fatty liver disease. J Med Ultrasonics 50, 187–195 (2023). https://doi.org/10.1007/s10396-023-01293-z

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  • DOI: https://doi.org/10.1007/s10396-023-01293-z

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