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Ultrasonography findings for the diagnosis of renal oncocytoma

  • Review Article–Urology
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Abstract

Renal oncocytomas are rare benign epithelial tumors of the kidney. However, they are easily misdiagnosed as renal cancers, resulting in unnecessary radical nephrectomy. This review summarizes the use of ultrasound for the diagnosis of renal oncocytomas. On two-dimensional grayscale ultrasound, renal oncocytomas appear as solid, well-defined, round or oval, and relatively isoechoic or slightly hyperechoic masses. On color Doppler flow imaging, the “spoke-wheel” sign is evident. On power Doppler flow imaging, renal oncocytomas show mixed penetrating and peripheral patterns. Renal oncocytomas usually appear as highly enhanced on contrast-enhanced ultrasound images, and irregular nonenhanced areas in larger tumors. This review will help sonographers recognize renal oncocytomas.

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References

  1. Montironi R, Cheng L, Scarpelli M, et al. Pathology and genetics: tumours of the urinary system and male genital system: clinical implications of the 4th edition of the WHO classification and beyond. Eur Urol. 2016;70:120–3.

    Article  PubMed  Google Scholar 

  2. Omiyale AO, Carton J. Renal oncocytoma with vascular and perinephric fat invasion. Ther Adv Urol. 2019;11:1756287219884857.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Klein MJ, Valensi QJ. Proximal tubular adenomas of kidney with so-called oncocytic features. A clinicopathological study of 13 cases of a rarely reported neoplasm. Cancer. 1976;38:906–14.

    Article  CAS  PubMed  Google Scholar 

  4. Sinke RJ, Dijkhuizen T, Janssen B, et al. Fine mapping of the human renal oncocytoma-associated translocation (5;11)(q35;q13) breakpoint. Cancer Genet Cytogenet. 1997;96:95–101.

    Article  CAS  PubMed  Google Scholar 

  5. Anderson CB, Lipsky M, Nandula SV, et al. Cytogenetic analysis of 130 renal oncocytomas identify three distinct and mutually exclusive diagnostic classes of chromosome aberrations. Genes Chromosomes Cancer. 2020;59:6–12.

    Article  CAS  Google Scholar 

  6. Sobrinho-Simões MA, Nesland JM, Holm R, et al. Hürthle cell and mitochondrion-rich papillary carcinomas of the thyroid gland: an ultrastructural and immunocytochemical study. Ultrastruct Pathol. 1985;8:131–42.

    Article  PubMed  Google Scholar 

  7. Richard PO, Jewett MA, Bhatt JR, Evans AJ, et al. Active surveillance for renal neoplasms with oncocytic features is safe. J Urol. 2016;195:581–6.

    Article  PubMed  Google Scholar 

  8. Newhouse JH, Wagner BJ. Renal oncocytomas. Abdom Imaging. 1998;23:249–55.

    Article  CAS  PubMed  Google Scholar 

  9. Kuroda N, Toi M, Hiroi M, et al. Review of renal oncocytoma with focus on clinical and pathobiological aspects. Histol Histopathol. 2003;18:935–42.

    CAS  PubMed  Google Scholar 

  10. Romis L, Cindolo L, Patard JJ, et al. Frequency, clinical presentation and evolution of renal oncocytomas: multicentric experience from a European database. Eur Urol. 2004;45:53–7.

    Article  PubMed  Google Scholar 

  11. Luo J, Chen JD, Chen Q, et al. Contrast-enhanced ultrasound improved performance of breast imaging reporting and data system evaluation of critical breast lesions. World J Radiol. 2016;8:610–7.

    Article  PubMed  PubMed Central  Google Scholar 

  12. Tikkakoski T, Päivänsalo M, Alanen A, et al. Radiologic findings in renal oncocytoma. Acta Radiol. 1991;32:363–7.

    Article  CAS  PubMed  Google Scholar 

  13. Goiney RC, Goldenberg L, Cooperberg PL, et al. Renal oncocytoma: sonographic analysis of 14 cases. AJR Am J Roentgenol. 1984;143:1001–4.

    Article  CAS  PubMed  Google Scholar 

  14. Kachramanoglou C, Rafailidis V, Philippidou M, et al. Multiparametric sonography of hematologic malignancies of the testis: grayscale, color Doppler, and contrast-enhanced ultrasound and Strain elastographic appearances with histologic correlation. J Ultrasound Med. 2017;36:409–20.

    Article  PubMed  Google Scholar 

  15. Ambos MA, Bosniak MA, Valensi QJ, et al. Angiographic patterns in renal oncocytomas. Radiology. 1978;129:615–22.

    Article  CAS  PubMed  Google Scholar 

  16. Lou L, Teng J, Lin X, Zhang H. Ultrasonographic features of renal oncocytoma with histopathologic correlation. J Clin Ultrasound. 2014;42:129–33.

    Article  PubMed  Google Scholar 

  17. Jinzaki M, Ohkuma K, Tanimoto A, et al. Small solid renal lesions: usefulness of power Doppler US. Radiology. 1998;209:543–50.

    Article  CAS  PubMed  Google Scholar 

  18. Setola SV, Catalano O, Sandomenico F, et al. Contrast-enhanced sonography of the kidney. Abdom Imaging. 2007;32:21–8.

    Article  CAS  PubMed  Google Scholar 

  19. Villanueva LAA, Knust M, Quintella L, et al. Renal oncocytoma in a kidney transplant patient: the imaging features on contrast-enhanced ultrasonography (CEUS): a case report. J Bras Nefrol. 2018;40:86–90.

    Article  PubMed  PubMed Central  Google Scholar 

  20. Gerst S, Hann LE, Li D, et al. Evaluation of renal masses with contrast-enhanced ultrasound: initial experience. AJR Am J Roentgenol. 2011;197:897–906.

    Article  PubMed  PubMed Central  Google Scholar 

  21. Schwarze V, Marschner C, Negrão de Figueiredo G, et al. Single-center study: the diagnostic performance of contrast-enhanced ultrasound (CEUS) for assessing renal oncocytoma. Scand J Urol. 2020;54:135–40.

    Article  PubMed  Google Scholar 

  22. Wu J, Zhu Q, Zhu W, et al. Comparative study of CT appearances in renal oncocytoma and chromophobe renal cell carcinoma. Acta Radiol. 2016;57:500–6.

    Article  PubMed  Google Scholar 

  23. Jiang J, Chen Y, Zhou Y, et al. Clear cell renal cell carcinoma: contrast-enhanced ultrasound features relation to tumor size. Eur J Radiol. 2010;73:162–7.

    Article  PubMed  Google Scholar 

  24. Johnson PT, Nazarian LN, Feld RI, et al. Sonographically guided renal mass biopsy: indications and efficacy. J Ultrasound Med. 2001;20:749–53.

    Article  CAS  PubMed  Google Scholar 

  25. Jaff A, Molinié V, Mellot F, et al. Evaluation of imaging-guided fine-needle percutaneous biopsy of renal masses. Eur Radiol. 2005;15:1721–6.

    Article  PubMed  Google Scholar 

  26. Park SY, Park BK, Kim CK, et al. Ultrasound-guided core biopsy of small renal masses: diagnostic rate and limitations. J Vasc Interv Radiol. 2013;24:90–6.

    Article  PubMed  Google Scholar 

  27. Silverman SG, Israel GM, Herts BR, et al. Management of the incidental renal mass. Radiology. 2008;249:16–31.

    Article  PubMed  Google Scholar 

  28. Silverman SG, Gan YU, Mortele KJ, et al. Renal masses in the adult patient: the role of percutaneous biopsy. Radiology. 2006;240:6–22.

    Article  PubMed  Google Scholar 

  29. Clark TW, Millward SF, Gervais DA, et al. Reporting standards for percutaneous thermal ablation of renal cell carcinoma. J Vasc Interv Radiol. 2006;17:1563–70.

    Article  PubMed  Google Scholar 

  30. Ljungberg B, Bensalah K, Canfield S, et al. EAU guidelines on renal cell carcinoma: 2014 update. Eur Urol. 2015;67:913–24.

    Article  PubMed  Google Scholar 

  31. Marconi L, Dabestani S, Lam TB, et al. Systematic review and meta-analysis of diagnostic accuracy of percutaneous renal tumour biopsy. Eur Urol. 2016;69:660–73.

    Article  PubMed  Google Scholar 

  32. Pandharipande PV, Gervais DA, Hartman RI, et al. Renal mass biopsy to guide treatment decisions for small incidental renal tumors: a cost-effectiveness analysis. Radiology. 2010;256:836–46.

    Article  PubMed  PubMed Central  Google Scholar 

  33. Chao DH, Zisman A, Pantuck AJ, et al. Changing concepts in the management of renal oncocytoma. Urology. 2002;59:635–42.

    Article  PubMed  Google Scholar 

  34. Pillay K, Lazarus J, Wainwright HC. Association of angiomyolipoma and oncocytoma of the kidney: a case report and review of the literature. J Clin Pathol. 2003;56:544–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  35. Mugiya S, Nagata M, Ozono S, et al. Ultrasonographic features of chromophobe cell renal carcinoma. Hinyokika Kiyo. 2004;50:865–8.

    PubMed  Google Scholar 

  36. Hartman DS, Goldman SM, Friedman AC, et al. Angiomyolipoma: ultrasonic-pathologic correlation. Radiology. 1981;139:451–8.

    Article  CAS  PubMed  Google Scholar 

  37. Jinzaki M, Tanimoto A, Narimatsu Y, et al. Angiomyolipoma: imaging findings in lesions with minimal fat. Radiology. 1997;205:497–502.

    Article  CAS  PubMed  Google Scholar 

  38. Jinzaki M, Silverman SG, Akita H, et al. Renal angiomyolipoma: a radiological classification and update on recent developments in diagnosis and management. Abdom Imaging. 2014;39:588–604.

    Article  PubMed  PubMed Central  Google Scholar 

  39. Wobker SE, Williamson SR. Modern pathologic diagnosis of renal oncocytoma. J Kidney Cancer VHL. 2017;4:1–12.

    Article  PubMed  PubMed Central  Google Scholar 

  40. Pearse HD, Houghton DC. Renal oncocytoma. Urology. 1979;13:73–7.

    Article  Google Scholar 

  41. Tamai H, Takiguchi Y, Oka M, et al. Contrast-enhanced ultrasonography in the diagnosis of solid renal tumors. J Ultrasound Med. 2005;24:1635–40.

    Article  PubMed  Google Scholar 

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Funding

This work was supported by the Provincial Bureau Project of Jilin (Grant Number 2019SCZ020).

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Authors and Affiliations

  1. Department of Ultrasound, China–Japan Union Hospital of Jilin University, No. 126 Xiantai Street, Changchun, 130033, Jilin Province, China

    Shengnan Zhao, Jiahong Shi, Ran Yang, Xiujuan Zhang, Wei Zhao & Zhixia Sun

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  1. Shengnan Zhao
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  2. Jiahong Shi
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  3. Ran Yang
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  4. Xiujuan Zhang
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  5. Wei Zhao
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  6. Zhixia Sun
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Correspondence to Zhixia Sun.

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Zhao, S., Shi, J., Yang, R. et al. Ultrasonography findings for the diagnosis of renal oncocytoma. J Med Ultrasonics 49, 211–216 (2022). https://doi.org/10.1007/s10396-021-01179-y

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  • DOI: https://doi.org/10.1007/s10396-021-01179-y

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