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Evaluation of malignancy of hepatocellular carcinoma using the ultrasonic B-mode method: clinical significance of extracapsular invasion of hepatocellular carcinoma using ultrasonography

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Abstract

Purpose

To determine the influence of capsule formation or presence of capsular invasion on the prognosis of hepatocellular carcinoma (HCC) patients.

Methods

The patient group consisted of 70 patients with 74 HCC lesions who had been examined by US and undergone surgical tumor resection at our institution. For these patients, we conducted the following comparative studies: (a) comparison between halo findings on US and microscopic capsular results; (b) comparison between halo findings on US and tumor diameter, tumor histological differentiation, and serum value of each tumor marker; and (c) comparison between halo findings on US and tumor recurrence.

Results

(a) The corresponding value between sonographic halo and histological capsule was 90.1%, and that between presence of extracapsular invasion on US and that seen by histology was 88.0%. (b) There was no relation between US images and histological differentiation of tumors. (c) Presence of extracapsular invasion on US was a predisposing factor for the development of tumor recurrence.

Conclusion

(1) Globally speaking, sonographic halo corresponded to the histological tumor capsule. (2) In patients with extracapsular invasion, tumor recurrence after treatment increased. Thus, a better understanding of sonographic halo findings helps determine diagnostic and therapeutic strategies in HCC patients.

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Authors and Affiliations

  1. Division of Gastroenterology and Hepatology, Surugadai Nihon University Hospital, 1-8-13 Kanda Surugadai, Chiyoda-ku, Tokyo, 101-8309, Japan

    Hiroshi Nakagawara, Masahiro Ogawa, Naoki Matsumoto, Yoshikazu Hiroi, Toshiki Yamamoto, Yoshiki Ono & Yasuyuki Arakawa

  2. Division of Digestive Surgery, Nihon University Itabashi Hospital, Tokyo, Japan

    Tadatoshi Takayama

  3. Department of Pathology, Surugadai Nihon University Hospital, Tokyo, Japan

    Noriko Kinukawa

  4. Center of Diagnostic Ultrasound, Akita Red Cross Hospital, Akita, Japan

    Hideaki Ishida

Authors
  1. Hiroshi Nakagawara
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  2. Masahiro Ogawa
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  3. Naoki Matsumoto
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  4. Yoshikazu Hiroi
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  5. Toshiki Yamamoto
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  6. Yoshiki Ono
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  7. Yasuyuki Arakawa
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  8. Tadatoshi Takayama
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  9. Noriko Kinukawa
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  10. Hideaki Ishida
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Corresponding author

Correspondence to Hiroshi Nakagawara.

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Nakagawara, H., Ogawa, M., Matsumoto, N. et al. Evaluation of malignancy of hepatocellular carcinoma using the ultrasonic B-mode method: clinical significance of extracapsular invasion of hepatocellular carcinoma using ultrasonography. J Med Ultrasonics 34, 83–91 (2007). https://doi.org/10.1007/s10396-007-0142-2

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  • DOI: https://doi.org/10.1007/s10396-007-0142-2

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