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Measurement of renal blood flow in human subjects using the ultrasound velocity profiling technique

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Abstract

Purpose

To (1) assess the accuracy of the ultrasound velocity profiling (USVP) technique of renal blood flow (RBF) measurement in normal subjects and (2) compare renal blood flow measurements obtained using USVP and renal clearance rate in patients with renal diseases.

Methods

First, we calculated unilateral renal blood flow (unil-RBF) using USVP and the clearance rate of para-aminohippuric acid (CPAH) simultaneously in six healthy male subjects. We then compared unil-RBFUSVP and unil-RBFPAH in nine patients with chronic glomerulonephritis (CGN).

Results

In the first study, the limits of agreement in a Bland-Altman plot ranged from −325.3 to 32.0 ml/min per 1.48 m2. The mean bias was −146.7 ml/min per 1.48 m2. Subdivision for values of unil-RBFUSVP by flow showed small discrepancies in values above 280 ml/min per 1.48 m2: mean bias, −98.2 ml/min per 1.48 m2; limits of agreement, −223.3 to 26.8 ml/min per 1.48 m2. The three patients in the second study had immunoglobulin A (IgA) nephropathy, in whom unil-RBFPAH was estimated as being markedly lower than unil-RBFUSVP, contrary to the primary result.

Conclusion

Despite its consistent negative bias, USVP may be a reliable method of quantifying renal blood flow noninvasively when measured values exceed 280 ml/min per 1.48 m2. We assumed that the p-aminohippurate extraction rate (EPAH) was profoundly impaired in the three patients with IgA nephropathy.

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References

  1. AJ Apperloo D de Zeeuw PE De Jong (1997) ArticleTitleA short-term anti-hypertensive treatment-induced fall in glomerular filtration rate predicts long-term stability of renal function Kidney Int 51 793–7 Occurrence Handle9067912 Occurrence Handle1:STN:280:ByiB38%2FnsFQ%3D

    PubMed  CAS  Google Scholar 

  2. HW Smith (1951) The kidney: structure and function in health and disease Oxford University Press New York

    Google Scholar 

  3. JV Warren E Brannon A Merrill (1944) ArticleTitleA method for obtaining renal venous blood in unanesthetized persons with observations on exhalation of oxygen and sodium para-aminohippurate Science 100 108–10 Occurrence Handle17788932

    PubMed  Google Scholar 

  4. SE Bradley GP Bradley CJ Tyson et al. (1950) ArticleTitleRenal function in renal disease Am J Med 9 766–98 Occurrence Handle14789797 Occurrence Handle1:STN:280:Cy6D3MbjsVM%3D Occurrence Handle10.1016/0002-9343(50)90292-0

    Article  PubMed  CAS  Google Scholar 

  5. EK Brodwall (1960) ArticleTitleRenal extraction of PAH in renal disease Scand J Clin Lab Invest 16 12–20

    Google Scholar 

  6. JH Bergstrom B Bucht B Josephson et al. (1959) ArticleTitleThe renal extraction of para-aminohippurate in normal persons and in patients with diseased kidneys Scand J Clin Lab Invest 11 361–75 Occurrence Handle13799449 Occurrence Handle1:CAS:528:DyaF3MXjvFSisQ%3D%3D

    PubMed  CAS  Google Scholar 

  7. WH Carghill (1948) ArticleTitleThe measurement of glomerular and tubular plasma flow in the normal and diseased human kidney J Clin Invest 28 189–92

    Google Scholar 

  8. O Shemesh JC Ross WM Deen et al. (1986) ArticleTitleNature of glomerular capillary injury in human membranous glomerulopathy J Clin Invest 77 868–77 Occurrence Handle2419362 Occurrence Handle1:STN:280:BimC2c%2FnsVY%3D

    PubMed  CAS  Google Scholar 

  9. R Takano N Taniguchi K Itoh et al. (1997) ArticleTitleMeasurement of blood flow via velocity profiles using color Doppler signals: experimental estimation of femoral artery blood flow in the dog Ultrasound Int 3 127–33

    Google Scholar 

  10. A Chagnac BA Kiberd MC Farinas et al. (1989) ArticleTitleOutcome of the acute glomerular injury in proliferative lupus nephritis J Clin Invest 84 922–30 Occurrence Handle2760219 Occurrence Handle1:STN:280:BiaA2c%2FptlQ%3D

    PubMed  CAS  Google Scholar 

  11. H Golbetz V Black O Shemesh et al. (1989) ArticleTitleMechanism of the antiproteinuric effect of indomethacin in nephrotic humans Am J Physiol 256 F44–51 Occurrence Handle2463770 Occurrence Handle1:CAS:528:DyaL1MXovVehsg%3D%3D

    PubMed  CAS  Google Scholar 

  12. O Shemesh JC Ross WM Deen et al. (1986) ArticleTitleNature of the glomerular capillary injury in human membranous glomerulopathy J Clin Invest 77 868–77 Occurrence Handle2419362 Occurrence Handle1:STN:280:BimC2c%2FnsVY%3D

    PubMed  CAS  Google Scholar 

  13. N Taniguchi R Takano K Itoh et al. (2003) ArticleTitleIntraobserver reproducibility and interobserver agreement of ultrasonic flowmetry using the velocity profile color Doppler method in the common carotid artery J Med Ultrasonics 30 3–11

    Google Scholar 

  14. JM Bland DG Altman (1986) ArticleTitleStatistical methods for assessing agreement between two methods of clinical measurements Lancet 8 307–10

    Google Scholar 

  15. A Heimdal H Torp (1997) ArticleTitleUltrasound Doppler measurements of low velocity blood flow: limitations due to clutter signals from vibrating muscles IEEE Trans Ultrason Ferroelec Freq Contr 44 873–81 Occurrence Handle10.1109/58.655202

    Article  Google Scholar 

  16. WH Hulet DS Baldwin AW Biggs et al. (1960) ArticleTitleRenal function in the separate kidneys of man. I. Hemodynamics and excretion of solute and water in normal subjects J Clin Invest 39 389–94 Occurrence Handle14403937 Occurrence Handle1:CAS:528:DyaF3cXotFymtQ%3D%3D

    PubMed  CAS  Google Scholar 

  17. R Takano A Yasuhiro N Taniguchi et al. (2001) ArticleTitlePower Doppler sonography of the kidney: effect of Valsalva's maneuver JCU 29 384–8 Occurrence Handle11579400 Occurrence Handle1:STN:280:DC%2BD3MrjtV2htw%3D%3D

    PubMed  CAS  Google Scholar 

  18. LD Dworkin AM Sun BM Brenner (2000) The renal circulations BM Brenner (Eds) Brenner and Rector's the kidney, vol. 1 Saunders Philadelphia 277–319

    Google Scholar 

  19. LE Earley RM Friedler (1965) ArticleTitleStudies on the mechanism of natriuresis accompanying increased renal blood flow and its role in the renal response to extracellular volume expansion J Clin Invest 44 1857–65 Occurrence Handle5843716 Occurrence Handle1:STN:280:CCmD2c7nsFw%3D Occurrence Handle10.1172/JCI105293

    Article  PubMed  CAS  Google Scholar 

  20. CA Visscher D de Zeeuw PE De Jong et al. (1995) ArticleTitleDrug-induced changes in renal hippurate clearance as a measure of renal blood flow Kidney Int 48 1617–23 Occurrence Handle8544423 Occurrence Handle1:CAS:528:DyaK2MXpvVSgtbc%3D

    PubMed  CAS  Google Scholar 

  21. RL Wolf BF King VE Torres et al. (1993) ArticleTitleMeasurement of normal renal artery blood flow: cine phase-contrast MR imaging vs clearance of p-aminohippurate AJR Am J Roentgenol 161 995–1002 Occurrence Handle8273644 Occurrence Handle1:STN:280:ByuD1MbitVQ%3D

    PubMed  CAS  Google Scholar 

  22. C Battilana H Zhang RA Olshen et al. (1991) ArticleTitlePAH extraction and estimation of plasma flow in diseased human kidneys Am J Physiol 261 F726–33 Occurrence Handle1928382 Occurrence Handle1:CAS:528:DyaK3MXmslOjs7k%3D

    PubMed  CAS  Google Scholar 

  23. InstitutionalAuthorNameResearch group on progressive chronic renal disease (1999) ArticleTitleNationwide and long-term survey of primary glomerulonephritis in Japan as observed in 1850 biopsied cases Nephron 82 205–13 Occurrence Handle10.1159/000045404

    Article  Google Scholar 

  24. AB Geers HA Koomans JC Roos et al. (1984) ArticleTitleFunctional relationships in the nephritic syndrome Kidney Int 26 324–30 Occurrence Handle6392692 Occurrence Handle1:STN:280:BiqD1cvitVE%3D

    PubMed  CAS  Google Scholar 

  25. G Corrigan D Ramaswamy O Kwon et al. (1999) ArticleTitlePAH extraction and estimation of plasma flow in human postischemic acute renal failure Am J Physiol 277 F312–8 Occurrence Handle10444587 Occurrence Handle1:CAS:528:DyaK1MXls1alsL8%3D

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Clinical Laboratory Medicine, Jichi Medical School Hospital, Yakushiji 3311-1, Shimotsuke, Tochigi, 329-0431, Japan

    Ryuichi Takano, Nobuyuki Taniguchi & Kouichi Itoh

  2. Department of Nephrology, Jichi Medical School, Shimotsuke, Tochigi, Japan

    Eiji Kusano

Authors
  1. Ryuichi Takano
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  2. Nobuyuki Taniguchi
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  3. Kouichi Itoh
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  4. Eiji Kusano
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Correspondence to Ryuichi Takano.

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Takano, R., Taniguchi, N., Itoh, K. et al. Measurement of renal blood flow in human subjects using the ultrasound velocity profiling technique. J Med Ultrasonics 33, 91–97 (2006). https://doi.org/10.1007/s10396-005-0088-1

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  • DOI: https://doi.org/10.1007/s10396-005-0088-1

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