, Volume 16, Issue 3, pp 558–569 | Cite as

Hantavirus Pulmonary Syndrome Risk in Entre Ríos, Argentina

  • María Victoria Vadell
  • Aníbal Eduardo Carbajo
  • Carolina Massa
  • Gerardo Rubén Cueto
  • Isabel Elisa Gómez VillafañeEmail author
Original Contribution


Hantavirus pulmonary syndrome (HPS) is a severe emerging endemic disease of the Americas. Because hantavirus reservoirs are sylvatic rodents, HPS risk has been associated with occupational and recreational activities in natural and rural environments. The aim of this study was to analyze the risk of HPS in an endemic province of Argentina. For this, we explored the relationship between HPS cases occurring in Entre Ríos province between 2004 and 2015 and climate, vegetation, landscape, reservoir population, and rodent community characteristics by means of generalized linear models. We modeled HPS occurrence at each site, and both the incidence and number of cases grouped by department. The resulting best model of each analysis was applied in a GIS to build HPS risk maps. Risk of occurrence of HPS increased with tree cover and decreased with distance to rivers. We identified the south of Entre Ríos as the area with higher HPS risk, and therefore, where HPS prevention measures should be more urgently applied. Risk maps based on data available in the public domain are a useful tool that should be used by decision makers to concentrate surveillance and control efforts in those areas with highest HPS risk.


Hantavirus pulmonary syndrome Disease Epidemiology Risk Zoonosis Public health 



We are thankful to the National Health Ministry of Argentina (Ministerio de Salud de la Nación) for providing the data on confirmed HPS cases and, to the anonymous reviewers for improving the manuscript with their comments and suggestions.

Compliance with Ethical Standards

Conflict of interest

The authors declare no conflict of interest.

Supplementary material

10393_2019_1425_MOESM1_ESM.doc (268 kb)
Supplementary material 1 (DOC 268 kb)
10393_2019_1425_MOESM2_ESM.doc (40 kb)
Supplementary material 2 (DOC 39 kb)


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Copyright information

© EcoHealth Alliance 2019

Authors and Affiliations

  • María Victoria Vadell
    • 1
    • 2
  • Aníbal Eduardo Carbajo
    • 1
    • 2
  • Carolina Massa
    • 3
  • Gerardo Rubén Cueto
    • 2
    • 3
  • Isabel Elisa Gómez Villafañe
    • 2
    • 3
    Email author
  1. 1.Instituto Nacional de Investigación e Ingeniería AmbientalUniversidad de San MartínSan MartínArgentina
  2. 2.Consejo Nacional de Investigaciones Científicas y TécnicasBuenos AiresArgentina
  3. 3.Departamento de Ecología, Genética y Evolución - IEGEBA, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Intendente Güiraldes 2160Buenos AiresArgentina

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