Mercury is a well-known environmental toxicant, particularly in its most common organic form, methylmercury. Consumption of fish and shellfish that contain methylmercury is a dominant source of mercury exposure in humans and piscivorous wildlife. Considerable efforts have focused on assessment of mercury and its attendant risks in the environment and food sources, including the studies reported in this issue. However, studies of mercury intoxication have frequently failed to consider the protective effects of the essential trace element, selenium. Mercury binds to selenium with extraordinarily high affinity, and high maternal exposures inhibit selenium-dependent enzyme activities in fetal brains. However, increased maternal dietary selenium intakes preserve these enzyme activities, thereby preventing the pathological effects that would otherwise arise in their absence. Recent evidence indicates that assessments of mercury exposure and tissue levels need to consider selenium intakes and tissue distributions in order to provide meaningful risk evaluations.
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Bulato C, Bosello V, Ursini F, Maiorino M (2007) Effect of mercury on selenium utilization and selenoperoxidase activity in LNCaP cells. Free Radical Biology and Medicine 42:118–123
Chapman L, Chan HM (2000) The influence of nutrition on methylmercury intoxication. Environmental Health Perspectives 108:29–56
Chen C, Yu H, Zhao J, Li B, Qu L, Liu S, et al. (2006) The roles of serum selenium and selenoproteins on mercury toxicity in environmental and occupational exposure. Environmental Health Perspectives 114:297–301
Chen CY, Serrell N, Evers DC, Fleishman BJ, Lambert KF, Weiss J, et al. (2008) Methylmercury in marine ecosystems: from sources to seafood consumers—a workshop report. Environmental Health Perspectives; DOI:10.1289/ehp.1121
Cuvin-Aralar ML, Furness RW (1991) Mercury and selenium interaction: a review. Ecotoxicology and Environmental Safety 21:348–364
Driscoll C, Han YJ, Chen CY, Evers DC, Lambert KF, Holsen TM, et al. (2007) Mercury contamination in forest and freshwater ecosystems in the northeastern United States. Bioscience 57:17–28
Dyrssen D, Wedborg M (1991) The sulfur–mercury(II) system in natural waters. Water, Air, and Soil Pollution 56:507–519
Falnoga I, Tusek-Znidaric M, Stegnar P (2006) The influence of long-term mercury exposure on selenium availability in tissues: an evaluation of data. BioMetals 19:283–294
Koelman JH, Peeters WHM, Koudstaal-Hol CHM (1973) Mercury-selenium correlations in marine mammals. Nature 245:385–386
Kosta L, Byrne AR, Zelenko V (1975) Correlation between selenium and mercury in man following exposure to inorganic mercury. Nature 254:238–239
Mergler D, Anderson HA, Chan HM, Mahaffey KR, Murray M, Sakamoto M, et al. (2007) Methylmercury exposure and health effects in humans: a worldwide concern. Ambio 36:3–11
Mostert V, Lombeck I, Abel J (1998). A novel method for the purification of Selenoprotein P from human plasma. Archives of Biochemisty and Biophysics 357:326-330
Ralston NVC, Blackwell JL, Raymond LJ (2007) Importance of molar ratios in selenium-dependent protection against methylmercury toxicity. Biological Trace Element Research 119:255–268
Ralston NVC, Ralston CR, Blackwell JL III, Raymond LJ (2008) Dietary and tissue selenium in relation to methylmercury toxicity. Neurotoxicology 29:802–811
Raymond LJ, Ralston NVC (2004) Mercury: selenium interactions and health implications. Seychelles Medical and Dental Journal 7:72–77
Sasakura C, Suzuki KT (1998) Biological interaction between transition metals (Ag, Cd and Hg), selenide/sulfide and selenoprotein P. Journal of Inorganic Biochemistry 71:159–162
Scheuhammer AM, Meyer MW, Sandheinrich MB, Murray MW (2007) Effects of environmental methylmercury on the health of wild birds, mammals, and fish. Ambio 36:12–18
Sunderland EM (2007) Mercury exposure from domestic and imported estuarine and marine fish in the U.S. seafood market. Environmental Health Perspectives 115:235–242
Takeuchi T, Morikawa N, Matsumoto H, Shiraishi Y (1962) A pathological study of Minamata disease in Japan. Acta Neuropathologica 2:40–57
Watanabe C, Yoshida K, Kasanuma Y, Kun Y, Satoh H (1999) In utero methylmercury exposure differentially affects the activities of selenoenzymes in the fetal mouse brain. Environmental Research 80:208–214
Yan J, Barrett JN (1998). Purification from Bovine serum of a survival-promoting factor for cultured central neurons and its identification as Selenoprotein-P. Journal of Neuroscience 18:8682-8691
Yoneda S, Suzuki KT (1997) Equimolar Hg-Se complex binds to selenoprotein P. Biochemical and Biophysical Research Communications 231: 7–11
MJB is supported by the NIH. NVCR is supported by the EPA and NOAA.
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Berry, M.J., Ralston, N.V.C. Mercury Toxicity and the Mitigating Role of Selenium. EcoHealth 5, 456–459 (2008). https://doi.org/10.1007/s10393-008-0204-y
- heavy metals