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Predictors of low bone mass in postmenopausal Japanese women: a questionnaire-based study

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Abstract

Background

The burgeoning costs of nursing care and medical treatment have become a serious problem for Japan, a country with an aging population and declining birthrate. Disease prevention and control of runaway health care costs are two important issues. We are interested in osteoporosis in the elderly. Thus, we aimed to establish predictive factors of low bone mass or fracture in postmenopausal elderly women by means of a simple questionnaire.

Methods

Subjects were 107 postmenopausal Japanese women. All data in the present study were collected in 2006. The calcaneus stiffness index (SI) was determined by ultrasound bone densitometry. Urinary deoxypyridinoline (DPD), a marker of bone resorption, was measured. Factors related to bone loss and fracture were investigated by means of a questionnaire and tested by regression analysis and analysis of variance.

Results

The SI correlated significantly with age, years since menopause, weight, and the DPD level. Change in body weight did not influence the SI, but lumbar pain, height loss, and stoop did influence the SI. The SI was significantly low in subjects who had already suffered a fracture. Body mass index (BMI) was the strongest predictor of the SI.

Conclusion

Low bone mass or fracture may be predicted in part with a simple questionnaire that addresses personal factors related to bone health.

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References

  • Blake GM, Fogelman I (2007) Role of dual-energy X-ray absorptiometry in the diagnosis and treatment of osteoporosis. J Clin Densitom 10:102–110

    Article  PubMed  Google Scholar 

  • DeBar LL, Ritenbaugh C, Vuckovic N, Stevens VJ, Aickin M, Elliot D, Moe E, Orwoll E, Ernst D, Irving LM (2004) YOUTH: decisions and challenges in designing an osteoporosis prevention intervention for teen girls. Prev Med 39:1047–1055

    Article  PubMed  Google Scholar 

  • de Papp AE, Bone HG, Caulfield MP, Kagan R, Buinewicz A, Chen E, Rosenberg E, Reitz RE (2007) A cross-sectional study of bone turnover markers in healthy premenopausal women. Bone 40:1222–1230

    Article  PubMed  Google Scholar 

  • Desai MP, Bhanuprakash KV, Khatkhatay MI, Donde UM (2007) Age-related changes in bone turnover markers and ovarian hormones in premenopausal and postmenopausal Indian women. J Clin Lab Anal 21:55–60

    Article  PubMed  CAS  Google Scholar 

  • Frost ML, Fogelman I, Blake GM, Marsden PK, Cook G Jr (2004) Dissociation between global markers of bone formation and direct measurement of spinal bone formation in osteoporosis. J Bone Miner Res 19:1797–1804

    Article  PubMed  CAS  Google Scholar 

  • Gemalmaz A, Discigil G, Sensoy N, Basak O (2007) Identifying osteoporosis in a primary care setting with quantitative ultrasound: relationship to anthropometric and lifestyle factors. J Bone Miner Metab 25:184–192

    Article  PubMed  Google Scholar 

  • Iba K, Takada J, Yamashita T (2004) The serum level of bone-specific alkaline phosphatase activity is associated with aortic calcification in osteoporosis patients. J Bone Miner Metab 22:594–596

    Article  PubMed  CAS  Google Scholar 

  • Iki M, Morita A, Ikeda Y, Sato Y, Akiba T, Matsumoto T, Nishino H, Kagamimori S, Kagawa Y, Yoneshima H, JPOS Study Group (2007) Biochemical markers of bone turnover may predict progression to osteoporosis in osteopenic women: the JPOS Cohort Study. J Bone Miner Metab 25:122–129

    Article  PubMed  CAS  Google Scholar 

  • Inaba M (2006) Bone metabolic marker; recent progress (in Japanese). Clin Calcium 16:74–80

    PubMed  CAS  Google Scholar 

  • Kitagawa J, Omasu F, Nakahara Y (2001) Physical activity for suppression of bone and connective tissue resorption in elderly women. Osteoporos Jpn 9:669–674

    Google Scholar 

  • Kitagawa J, Omasu F, Nakahara Y (2003) Effect of daily walking steps on ultrasound parameters of the calcaneus in elderly Japanese women. Osteoporos Int 14:219–224

    PubMed  CAS  Google Scholar 

  • Kitatani K, Nakatsuka K, Naka H, Miki T, Morii H, Nishizawa Y (2003) Clinical usefulness of measurements of urinary deoxypyridinoline (DPD) in patients with postmenopausal osteoporosis receiving intermittent cyclical etidronate: advantage of free form of DPD over total DPD in predicting treatment efficacy. J Bone Miner Metab 21:217–224

    PubMed  CAS  Google Scholar 

  • Krupa B, Miazgowski T (2005) Bone mineral density and markers of bone turnover in boys with constitutional delay of growth and puberty. J Clin Endocrinol Metab 90:2828–2830

    Article  PubMed  CAS  Google Scholar 

  • Leslie WD, Tsang JF, Caetano PA, Lix LM, for the Manitoba Bone Density Program (2007) Number of osteoporotic sites and fracture risk assessment: a cohort study from the Manitoba Bone Density Program. J Bone Miner Res 22:476–483

    Article  PubMed  Google Scholar 

  • Mauck KF, Clarke BL (2006) Diagnosis, screening, prevention, and treatment of osteoporosis. Mayo Clin Proc 81:662–672

    Article  PubMed  CAS  Google Scholar 

  • Meszaros S, Toth E, Ferencz V, Csupor E, Hosszu E, Horvath C (2007) Calcaneous quantitative ultrasound measurements predicts vertebral fractures in idiopathic male osteoporosis. Joint Bone Spine 74:79–84

    Article  PubMed  Google Scholar 

  • Miller KK, Lee EE, Lawson EA, Misra M, Minihan J, Grinspoon SK, Gleysteen S, Mickley D, Herzog D, Klibanski A (2006) Determinants of skeletal loss and recovery in anorexia nervosa. J Clin Endocrinol Metab 91:2931–2937

    Article  PubMed  CAS  Google Scholar 

  • Millet P, Vilaseca MA, Valls C, Perez-Duenas B, Artuch R, Gomez L, Lambruschini N, Campistol J (2005) Is deoxypyridinoline a good resorption marker to detect osteopenia in phenylketonuria? Clin Biochem 38:1127–1132

    Article  PubMed  CAS  Google Scholar 

  • Moayyeri A, Ahmadi-Abhari S, Hossein-nezhad A, Larijani B, Soltani A (2006) Bone mineral density and estimated height loss based on patients’ recalls. Osteoporos Int 17:834–840

    Article  PubMed  CAS  Google Scholar 

  • Nestel P, Lyu R, Low LP, Sheu WH, Nitiyanant W, Saito I, Tan CE (2007) Metabolic syndrome: recent prevalence in East and Southeast Asian populations. Asia Pac J Clin Nutr 16:362–367

    PubMed  Google Scholar 

  • Omasu F, Kitagawa J, Koyama K, Asakawa K, Yokouchi J, Ando D, Nakahara Y (2004) The influence of VDR genotype and exercise on ultrasound parameters in young adult Japanese women. J Physiol Anthropol Appl Human Sci 23:49–55

    Article  PubMed  Google Scholar 

  • Ortolani S, Scotti A, Cherubini R (2003) Rapid suppression of bone resorption and parathyroid hormone secretion by acute oral administration of calcium in healthy adult men. J Endocrinol Invest 26:353–358

    PubMed  CAS  Google Scholar 

  • Piaggesi A, Rizzo L, Golia F, Costi D, Baccetti F, Ciaccio S, De Gregorio S, Vignali E, Trippi D, Zampa V, Marcocci C, Del Prato S (2002) Biochemical and ultrasound tests for early diagnosis of active neuro-osteoarthropathy (NOA) of the diabetic foot. Diabetes Res Clin Pract 58:1–9

    Article  PubMed  CAS  Google Scholar 

  • Pluijm SM, van Essen HW, Bravenboer N, Uitterlinden AG, Smit JH, Pols HA, Lips P (2004) Collagen type I alpha1 Sp1 polymorphism, osteoporosis, and intervertebral disc degeneration in older men and women. Ann Rheum Dis 63:71–77

    Article  PubMed  CAS  Google Scholar 

  • Rossini M, Viapiana O, Del Marco A, de Terlizzi F, Gatti D, Adami S (2007) Quantitative ultrasound in adults with cystic fibrosis: correlation with bone mineral density and risk of vertebral fractures. Calcif Tissue Int 80:44–49

    Article  PubMed  CAS  Google Scholar 

  • Ruohola JP, Laaksi I, Ylikomi T, Haataja R, Mattila VM, Sahi T, Tuohimaa P, Pihlajamaki H (2006) Association between serum 25(OH)D concentrations and bone stress fractures in Finnish young men. J Bone Miner Res 21:1483–1488

    Article  PubMed  CAS  Google Scholar 

  • Shapses SA, Riedt CS (2006) Bone, body weight, and weight reduction: what are the concerns? J Nutr 136:1453–1456

    PubMed  CAS  Google Scholar 

  • Tauchmanovà L, Nuzzo V, Del Puente A, Fonderico F, Esposito-Del Puente A, Padulla S, Rossi A, Bifulco G, Lupoli G, Lombardi G (2004) Reduced bone mass detected by bone quantitative ultrasonometry and DEXA in pre- and postmenopausal women with endogenous subclinical hyperthyroidism. Maturitas 48:299–306

    Article  PubMed  Google Scholar 

  • Tobias JH, Hutchinson AP, Hunt LP, McCloskey EV, Stone MD, Martin JC, Thompson PW, Palferman TG, Bhalla AK (2007) Use of clinical risk factors to identify postmenopausal women with vertebral fractures. Osteoporos Int 18:35–43

    Article  PubMed  CAS  Google Scholar 

  • Zhao LJ, Liu YJ, Liu PY, Hamilton J, Recker RR, Deng HW (2007) Relationship of obesity with osteoporosis. J Clin Endocrinol Metab 92:1640–1646

    Article  PubMed  CAS  Google Scholar 

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Acknowledgments

We are grateful to Ranko Ejiri for expert secretarial assistance. This work was supported in part by the Chiyoda Health Development Agency Foundation.

Conflict of interest statement

The authors confirm that there are no relevant associations that might pose a conflict of interest.

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Correspondence to Fumihiro Omasu.

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Omasu, F., Kitagawa, J., Ushiki, N. et al. Predictors of low bone mass in postmenopausal Japanese women: a questionnaire-based study. J Public Health 17, 61–66 (2009). https://doi.org/10.1007/s10389-008-0216-7

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  • DOI: https://doi.org/10.1007/s10389-008-0216-7

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