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Real-world treatment patterns and outcomes in Japanese patients with cervical esophageal cancer

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Abstract

Background

Cervical esophageal cancer (CEC) carries a poor prognosis; however, due to its low incidence, optimal treatment for CEC remains to be established. The purpose of this study was to clarify the current status of treatment of CEC in Japan and obtain evidence for establishing the appropriate treatment method.

Patients and methods

We asked specialist training facilities accredited by the Japanese Broncho-Esophageal Society to register data on CEC cases that received curative treatment from January 2009 to December 2014, and conducted a retrospective review of the clinical data of 302 cases registered from 27 facilities.

Results

In regard to the initial therapy, of the 302 patients, 33 had undergone endoscopic resection, 41 had undergone surgery, 67 had received induction chemotherapy (IC), and 143 had received chemoradiotherapy (CRT). There were no significant differences in the 5-year overall survival rates among the patient groups that had received surgery, IC or CRT as the initial treatment; advanced stage and recurrent nerve invasion were identified as independent poor prognostic factors. Among the patients who had received IC or CRT as laryngeal-preserving surgery was not indicated at the time of the initial diagnosis, the functional laryngeal preservation rate at the end of the observation period was 34.8%.

Conclusion

Even in patients with advanced CEC, there is the possibility of preserving the larynx by adopting IC or CRT. However, if the laryngeal function cannot be preserved, there is a risk of complications from aspiration pneumonia, so that the choice of treatment should be made carefully.

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Author information

Authors and Affiliations

  1. Department of Head and Neck Surgery, Tokyo Medical and Dental University, Tokyo, Japan

    Kazuchika Ohno & Takahiro Asakage

  2. Department of Esophageal and Gastroenterological Surgery, Juntendo University Faculty of Medicine, Tokyo, Japan

    Motomi Nasu

  3. Department of Head and Neck Cancer, Hyogo Cancer Center, Akashi, Japan

    Hidetoshi Matsui

  4. Department of Gastroenterological Surgery, Graduate School of Medical Science, Kumamoto University, Kumamoto, Japan

    Yoshifumi Baba

  5. Department of Surgery, School of Medicine, Kinki University, Osaka, Japan

    Takushi Yasuda

  6. Department of Surgery, NTT Medical Center Tokyo, Tokyo, Japan

    Jun Sakuma

  7. Department of Otolaryngology, School of Medicine, Showa University, Tokyo, Japan

    Kenichiro Ikeda

  8. Department of Otolaryngology, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan

    Takashi Maruo

  9. Department of Otorhinolaryngology, Head and Neck Surgery, Faculty of Medicine, Miyazaki University, Miyazaki, Japan

    Takumi Okuda

  10. Department of Otorhinolaryngology Head and Neck Surgery, Faculty of Medicine, Fukui University, Fukui, Japan

    Norihiko Narita

  11. Department of Otolaryngology-Head and Neck Surgery, School of Medicine, Fujita Health University, Toyoake, Aichi, Japan

    Hisayuki Kato

  12. Department of Otolaryngology, Japanese Red Cross Shizuoka Hospital, Shizuoka, Japan

    Taiji Kawasaki

  13. Division of Digestive Surgery, Department of Surgery, International Medical Center, Saitama Medical University, Hidaka, Japan

    Hiroshi Sato

  14. Department of Otorhinolaryngology, Head and Neck Surgery, Tokyo Medical University, Tokyo, Japan

    Kunihiko Tokashiki

  15. Division of Head and Neck Surgery, National Hospital Organization Shikoku Cancer Center, Matsuyama, Ehime, Japan

    Naoki Akisada

  16. Department of Otorhinolaryngology-Head and Neck Surgery, Mie University Graduate School of Medicine, Tsu, Japan

    Hajime Ishinaga

  17. Department of Otolaryngology, Kameda Medical Center, Chiba, Japan

    Ken Akashi

  18. Department of Otolaryngology, School of Medicine, Tokai University, Isehara, Japan

    Kenji Okami

  19. Department of Otolaryngology, Sapporo Medical University School of Medicine, Sapporo, Japan

    Kosuke Murayama

  20. Department of Gastrointestinal Surgery, Tokai University Hachioji Hospital, Tokyo, Japan

    Soichiro Yamamoto

  21. Department of Surgery, Fujioka General Hospital, Fujioka, Gunma, Japan

    Yuji Kumakura

  22. Department of Gastrointestinal Surgery, Tokyo Medical and Dental University, Tokyo, Japan

    Kenro Kawada

  23. Department of Otolaryngology-Head and Neck Surgery, National Defense Medical College, Saitama, Japan

    Akihiro Shiotani

  24. The Japan Broncho-Esophagological Society, Tokyo, Japan

    Akihiro Shiotani

Authors
  1. Kazuchika Ohno
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  2. Motomi Nasu
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  3. Hidetoshi Matsui
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  4. Yoshifumi Baba
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  24. Takahiro Asakage
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Corresponding author

Correspondence to Kazuchika Ohno.

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Ethical Statement

This study was conducted in accordance with the principles of the Declaration of Helsinki (1964) and its later versions, and information about the study was disclosed by displaying posters at each participating institution. At our institution, information about the study was disclosed on the website of the Bioethics Research Center.

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The authors declare that they have no conflict of interest to declare.

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Ohno, K., Nasu, M., Matsui, H. et al. Real-world treatment patterns and outcomes in Japanese patients with cervical esophageal cancer. Esophagus 19, 576–585 (2022). https://doi.org/10.1007/s10388-022-00921-w

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  • DOI: https://doi.org/10.1007/s10388-022-00921-w

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