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Postoperative infectious complications-driven recurrence after radical resection for esophageal cancer

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Few reports have reported the long-term outcome of esophageal cancer patients suffering from postoperative infectious complications. Here, we investigated the impact of postoperative infectious complications in patients who had undergone curative resection for esophageal cancer.


The study population comprised 97 patients who underwent radical resection for esophageal cancer with curative intent between 2001 and 2008. Postoperative infectious complications were defined as surgical site infections and pneumonia. We compared clinical features, tumor histology, recurrence, and overall survival between patients with postoperative infections and those who did not.


Of the 97 patients studied, 37 had postoperative infectious complications. The disease-free and overall survival rates of the entire cohort did not significantly differ between patients with and without postoperative infectious complications. Univariate analysis revealed that among patients with stage III esophageal cancer, those with postoperative infectious complications demonstrated significantly shorter disease-free survival than those without. Multivariate analysis demonstrated that postoperative infectious complications were independent prognostic indicators for disease-free survival of stage III esophageal cancer patients.


Our findings suggest that postoperative infectious complications in stage III esophageal cancer patients have a negative impact on disease-free survival.

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We would like to thank a statistician, Dr. Mari S. Oba, for her analysis and interpretation of the data, and Dr. Jonathan C. DeLong for his English proofreading in this manuscript. We are also grateful to all the surgeons for their important contribution to treating patients and collecting clinical data in the Yokohama City University.

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Correspondence to Chikara Kunisaki.

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Ethical Statement

All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1964 and later versions. Informed consent or substitute for it was obtained from all patients for being included in the study.

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All authors declare that they have no conflict of interest.

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Murakami, T., Kunisaki, C., Hasegawa, S. et al. Postoperative infectious complications-driven recurrence after radical resection for esophageal cancer. Esophagus 13, 343–350 (2016).

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