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Inflammatory myofibroblastic tumor in the esophagus after treatment for superficial esophageal cancer

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Abstract

A 76-year-old man was referred to our hospital for treatment of a submucosal tumor in the esophagus. The patient had a history of superficial esophageal cancer treated by endoscopic resection and radiation. Positron emission tomography showed intense localized uptake of fluorodeoxyglucose on the esophageal mass. Transthoracic esophagectomy and reconstruction with a gastric tube were performed. Histopathological examination revealed that the tumor consisted of a proliferation of atypical spindle cells with infiltration of many inflammatory cells. The spindle cells were positive for vimentin, alpha smooth muscle actin, and anaplastic lymphoma kinase immunostaining. The Ki-67 labeling index was 10–20 %. The tumor was finally diagnosed as inflammatory myofibroblastic tumor. Late phase inflammation caused by radiation potentially had an effect on the occurrence of the tumor in this case. For tumors of the irradiated esophagus, especially, careful pretreatment examination and treatment strategies with consideration of the radiation damage are important to obtaining a favorable outcome.

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References

  1. Coffin CM, Hornick JL, Fletcher CD. Inflammatory myofibroblastic tumor: comparison of clinicopathologic, histologic, and immunohistochemical features including ALK expression in atypical and aggressive cases. Am J Surg Pathol. 2007;31:509–20.

    Article  PubMed  Google Scholar 

  2. Gleason BC, Hornick JL. Inflammatory myofibroblastic tumours: where are we now? J Clin Pathol. 2008;61:428–37.

    Article  PubMed  CAS  Google Scholar 

  3. Coffin CM, Watterson J, Priest JR, Dehner LP. Extrapulmonary inflammatory myofibroblastic tumor (inflammatory pseudotumor). A clinicopathologic and immunohistochemical study of 84 cases. Am J Surg Pathol. 1995;19:859–72.

    Article  PubMed  CAS  Google Scholar 

  4. Cook JR, Dehner LP, Collins MH, Ma Z, Morris SW, Coffin CM, et al. Anaplastic lymphoma kinase (ALK) expression in the inflammatory myofibroblastic tumor: a comparative immunohistochemical study. Am J Surg Pathol. 2001;25:1364–71.

    Article  PubMed  CAS  Google Scholar 

  5. Kurihara K, Mizuseki K, Ichikawa M, Okada K, Miyata Y. Esophageal inflammatory pseudotumor mimicking malignancy. Intern Med. 2001;40:18–22.

    Article  PubMed  CAS  Google Scholar 

  6. Meissner K. Late radiogenic small bowel damage: guidelines for the general surgeon. Dig Surg. 1999;16:169–74.

    Article  PubMed  CAS  Google Scholar 

  7. Jindal T, Kumar A, Dutta R, Kumar R. Combination of (18)-FDG and (68)Ga-DOTATOC PET-CT to differentiate endobronchial carcinoids and inflammatory myofibroblastic tumors. J Postgrad Med. 2009;55:272–4.

    Article  PubMed  CAS  Google Scholar 

  8. Babar-Craig H, Gill H, Almeyda R, Wong WL, Farrell R. Inflammatory pseudotumour of the neck with multifocal sites on positron emission tomography scan imaging. J Laryngol Otol. 2005;119:219–21.

    PubMed  Google Scholar 

  9. Wolf BC, Khettry U, Leonardi HK, Neptune WB, Bhattacharyya AK, Legg MA. Benign lesions mimicking malignant tumors of the esophagus. Hum Pathol. 1988;19:148–54.

    Article  PubMed  CAS  Google Scholar 

  10. Li J, Liu F, Wang Z, Liu Q, Wang Y, Zhou Q, et al. Inflammatory pseudotumor of the esophagus—GI image. J Gastrointest Surg. 2010;14:195–8.

    Article  PubMed  Google Scholar 

  11. Miyata H, Yamasaki M, Takiguchi S, Nakajima K, Fujiwara Y, Nishida T, et al. Salvage esophagectomy after definitive chemoradiotherapy for thoracic esophageal cancer. J Surg Oncol. 2009;100:442–6.

    Article  PubMed  CAS  Google Scholar 

  12. Privette A, Fisk P, Leavitt B, Cooper K, McCahill L. Inflammatory myofibroblastic tumor presenting with esophageal obstruction and an inflammatory syndrome. Ann Thorac Surg. 2008;86:1364–7.

    Article  PubMed  Google Scholar 

  13. Stelow EB, Shami VM, Moskaluk CA, Burns KG, Legallo RD, Jones DR. Esophageal inflammatory myofibroblastic tumor sampled by EUS-FNA. Gastrointest Endosc. 2010;72:209–10.

    Article  PubMed  Google Scholar 

  14. Coffin CM, Patel A, Perkins S, Elenitoba-Johnson KS, Perlman E, Griffin CA. ALK1 and p80 expression and chromosomal rearrangements involving 2p23 in inflammatory myofibroblastic tumor. Mod Pathol. 2001;14:569–76.

    Article  PubMed  CAS  Google Scholar 

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Ethical Statement

We conformed to the guidelines set forth in the Helsinki Declaration revised in 2000. We gave consideration to the privacy of the patient, and the manuscript does not include any identifying information.

Conflict of interest

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Department of Surgery, Niigata Cancer Center Hospital, 3-15-2 Kawagishi-cho, Chuou-ku, Niigata, 951-8566, Japan

    Takeo Bamba, Satoru Nakagawa, Hiroshi Yabusaki, Masaki Aizawa, Atsushi Matsuki & Atsushi Nashimoto

  2. Department of Pathology, Niigata Cancer Center Hospital, Niigata, Japan

    Takashi Kawasaki & Keiichi Homma

Authors
  1. Takeo Bamba
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  2. Satoru Nakagawa
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  3. Hiroshi Yabusaki
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  4. Masaki Aizawa
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  5. Atsushi Matsuki
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  6. Takashi Kawasaki
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  7. Keiichi Homma
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  8. Atsushi Nashimoto
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Corresponding author

Correspondence to Takeo Bamba.

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Bamba, T., Nakagawa, S., Yabusaki, H. et al. Inflammatory myofibroblastic tumor in the esophagus after treatment for superficial esophageal cancer. Esophagus 11, 140–145 (2014). https://doi.org/10.1007/s10388-013-0399-z

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  • DOI: https://doi.org/10.1007/s10388-013-0399-z

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