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Therapy-related acute myeloid leukemia following postoperative adjuvant chemotherapy including cisplatin and fluorouracil for esophageal carcinoma

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Abstract

We report a case of therapy-related acute myeloid leukemia (t-AML), which developed following chemotherapy involving cisplatin and 5-fluorouracil for esophageal carcinoma. A 70-year-old man with past history of esophageal carcinoma, which was treated with subtotal esophagectomy 32 months earlier followed by 2 courses of chemotherapy involving cisplatin and 5-fluorouracil, was diagnosed with t-AML. His leukemia was resistant to chemotherapy, and the patient died from pneumonia 4 months after being diagnosed with leukemia. Although treatment for esophageal carcinoma is associated with a markedly lower frequency of therapy-related myeloid neoplasms than treatment for certain other malignancies such as hematological neoplasms, it is important to be aware that therapy-related myeloid neoplasms can occur as late complications of esophageal carcinoma treatment.

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The authors declare that they have no conflicts of interest.

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Authors and Affiliations

  1. Department of Hematology, Seichokai Fuchu Hospital, 1-10-17 Hiko-cho, Izumi, Osaka, 594-0076, Japan

    Masahiro Manabe, Hirofumi Nakano, Teruhito Takakuwa, Naonori Harada, Shuichiro Okamoto, Yasutaka Aoyama, Takeo Kumura, Tadanobu Ohta, Yoshio Furukawa & Atsuko Mugitani

  2. Department of Surgery, Seichokai Fuchu Hospital, Izumi, Japan

    Kinshi Kosaka & Kazuhiro Takeuchi

Authors
  1. Masahiro Manabe
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  2. Kinshi Kosaka
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  3. Hirofumi Nakano
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  4. Teruhito Takakuwa
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  5. Naonori Harada
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  6. Shuichiro Okamoto
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  7. Yasutaka Aoyama
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  8. Takeo Kumura
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  9. Tadanobu Ohta
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  10. Yoshio Furukawa
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  11. Kazuhiro Takeuchi
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  12. Atsuko Mugitani
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Corresponding author

Correspondence to Masahiro Manabe.

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Manabe, M., Kosaka, K., Nakano, H. et al. Therapy-related acute myeloid leukemia following postoperative adjuvant chemotherapy including cisplatin and fluorouracil for esophageal carcinoma. Esophagus 10, 174–178 (2013). https://doi.org/10.1007/s10388-013-0366-8

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  • DOI: https://doi.org/10.1007/s10388-013-0366-8

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