Skip to main content

Advertisement

SpringerLink
Log in

Double primary cancer of the esophagus consisting of ectopic gastric mucosa-derived adenocarcinoma and squamous cell carcinoma: a first case report

  • Case Report
  • Published:
Esophagus Aims and scope Submit manuscript

An Erratum to this article was published on 29 May 2012

Abstract

Most esophageal cancers are either squamous cell carcinomas or Barrett’s mucosa-derived adenocarcinomas. A 64-year-old man with a long history of alcohol drinking and smoking was found to have a tumor in the cervical esophagus on screening esophagography. Subsequent work-up revealed double primary cancer of the esophagus consisting of adenocarcinoma arising from ectopic gastric mucosa in the cervical esophagus and squamous cell carcinoma in the abdominal esophagus. He underwent subtotal esophagectomy. On microscopic examination of the resected specimen, the Ip tumor in the cervical esophagus was confirmed to be an adenocarcinoma derived from ectopic gastric mucosa that had invaded the muscularis mucosa, and the 0-IIb tumor located near the esophagogastric junction was confirmed to be a squamous cell carcinoma that had invaded the proper mucosal layer. No lymph node metastases were noted. Adenocarcinoma from ectopic gastric mucosa is rare, and its coexistence with squamous cell carcinoma is extremely rare.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

References

  1. Posner MC, Forastiere AA, Minsky BD. Cancer of the esophagus. In: Devita Vt, Hellman S, Rosenberg SA, editors. Cancer: principles and practice of oncology. 7th ed. Philadelphia: Lippincott Williams & Wilkins; 2005. p. 861–909.

    Google Scholar 

  2. Akbayir N, Sökmen HM, Caliş AB, Bölükbaş C, Erdem L, Alkim C, et al. Heterotopic gastric mucosa in the cervical esophagus: could this play a role in the pathogenesis of laryngopharyngeal reflux in a subgroup of patients with posterior laryngitis? Scand J Gastroenterol. 2005;40:1149–56.

    Article  PubMed  Google Scholar 

  3. Borhan-Manesh F, Farnum JB. Incidence of heterotopic gastric mucosa in the upper oesophagus. Gut. 1991;32:968–72.

    Article  PubMed  CAS  Google Scholar 

  4. Kumagai Y. Incidence of heterotropic gastric mucosa in the upper esophagus (inlet patch). Prog Dig Endosc. 2005;66:19–21. (In Japanese).

    Google Scholar 

  5. Hirayama N, Arima M, Miyazaki S, Shimada H, Okazumi S, Matsubara H, et al. Endoscopic mucosal resection of adenocarcinoma arising in ectopic gastric mucosa in the cervical esophagus: case report. Gastrointest Endosc. 2003;57:263–6.

    Article  PubMed  Google Scholar 

  6. von Rahden BH, Stein HJ, Becker K, Siewert RJ. Esophageal adenocarcinomas in heterotopic gastric mucosa: review and report of a case with complete response to neoadjuvant radiochemotherapy. Dig Surg. 2005;22:107–12.

    Article  Google Scholar 

  7. von Rahden BH, Stein HJ, Becker K, Liebermann-Meffert D, Siewert JR. Heterotopic gastric mucosa of the esophagus: literature-review and proposal of a clinicopathologic classification. Am J Gastroenterol. 2004;99:543–51.

    Article  Google Scholar 

  8. Poyrazoglu OK, Bahcecioglu IH, Dagli AF, Ataseven H, Celebi S, Yalniz M. Heterotopic gastric mucosa (inlet patch): endoscopic prevalence, histopathological, demographical and clinical characteristics. Int J Clin Pract. 2009;63:287–91.

    Article  PubMed  CAS  Google Scholar 

  9. Waring JP, Wo JM. Cervical esophageal web caused by an inlet patch of gastric mucosa. South Med J. 1997;90:554–5.

    Article  PubMed  CAS  Google Scholar 

  10. Satoh S, Nakashima T, Watanabe K, Toda S, Kuratomi Y, Sugihara H, et al. Hypopharyngeal squamous cell carcinoma bordering ectopic gastric mucosa “inlet parch” of the cervical esophagus. Auris Nasus Larynx. 2007;34:135–9.

    Article  PubMed  Google Scholar 

  11. Carrie A. Adenocarcinoma of the upper end of the oesophagus arising from ectopic gastric epithelium. Br J Surg. 1950;37:474.

    Article  PubMed  CAS  Google Scholar 

  12. Morson BC, Belcher JR. Adenocarcinoma of the esophagus and ectopic gastric mucosa. Br J Cancer. 1952;6:127–33.

    Article  PubMed  CAS  Google Scholar 

  13. Raphael HA, Ellis FH, Dockerty MB. Primary adenocarcinoma of the esophagus. Ann Surg. 1966;164:785–96.

    Article  PubMed  CAS  Google Scholar 

  14. Davis WM, Goodwin MN, Black HC Jr, Hawk JC, Charleston SC. Polypoid adenocarcinoma of the cervical esophagus. Arch Pathol Lab Med. 1969;88:367–70.

    CAS  Google Scholar 

  15. Jernstrom P, Brewer LA 3rd. Primary adenocarcinoma of the mid-esophagus arising in ectopic gastric mucosa with associated hiatal hernia and reflux esophagitis (Dawson’s syndrome). Cancer. 1970;26:1343–8.

    Article  PubMed  CAS  Google Scholar 

  16. Danhoff B, Cooper J, Klein M. Primary adenocarcinoma of the upper esophagus. Clin Radiol. 1978;29:519–22.

    Article  Google Scholar 

  17. Christensen W, Sternberg S. Adenocarcinoma of the upper esophagus arising in ectopic gastric mucosa—two case reports and review of the literature. Am J Surg Pathol. 1987;11:397–402.

    Article  PubMed  CAS  Google Scholar 

  18. Ishii K, Ota H, Nakayama J, Katsuyama T, Matsuzawa K, Honda T, et al. Adenocarcinoma of the cervical esophagus arising from ectopic gastric mucosa. Virchows A Pathol Anat. 1991;419:159–64.

    Article  CAS  Google Scholar 

  19. Takagi A, Ema Y, Horii S, Morishita M, Miyaishi O. Early adenocarcinoma arising from ectopic gastric mucosa in the cervical esophagus. Gastrointest Endosc. 1995;41:167–70.

    Article  PubMed  CAS  Google Scholar 

  20. Sperling RM, Grendell JH. Adenocarcinoma arising in an inlet patch of esophagus. Am J Gastroenterol. 1995;90:150–2.

    PubMed  CAS  Google Scholar 

  21. Pai S, DFeshpande R, Naresh KN. Adenocarcinoma of cervical esophagus arising in aberrant gastric mucosa. Indian J Gastroenterol. 1997;16:157–8.

    PubMed  CAS  Google Scholar 

  22. Berkelhammer C, Bhagavan M, Templeton A, Raines R, Walloch J. Gastric inlet patch containing submucosally infiltrating adenocarcinoma. J Clin Gastroenterol. 1997;25:678–81.

    Article  PubMed  CAS  Google Scholar 

  23. Lauwers GY, Scott GV, Vauthey JN. Adenocarcinoma of the upper esophagus arising in cervical ectopic gastric mucosa: rare evidence of malignant potential of so-called “inlet patch”. Dig Dis Sci. 1998;43:901–7.

    Article  PubMed  CAS  Google Scholar 

  24. Pech O, May A, Gossner L, Vieth M, Trump F, et al. Early stage adenocarcinoma of the esophagus arising in circular heterotopic gastric mucosa treated by endoscopic mucosal resection. Gastrointest Endosc. 2001;54:656–8.

    Article  PubMed  CAS  Google Scholar 

  25. Noguchi T, Takeno S, Takahashi Y, Sato T, Uchida Y, Yokoyama S. Primary adenocarcinoma of the cervical esophagus arising from heterotopic gastric mucosa. J Gastroenterol. 2001;36:704–9.

    Article  PubMed  CAS  Google Scholar 

  26. Klaase JM, Lemaire LCJM, Rauws EAJ, Offerhaus GJA, van Lanschot JJB. Heterotopic gastric mucosa of the cervical esophagus: a case of highgrade dysplasia treated with argon coagulation and a case of adenocarcinoma. Gastrointest Endosc. 2001;53:101–4.

    Article  PubMed  CAS  Google Scholar 

  27. Chatelain D, de Lajarte-Thirouard AS, Tiret E, Flejou JF. Adenocarcinoma of the upper esophagus arising in heterotopic gastric mucosa: common pathogenesis with Barrett’s adnocarcinoma? Virchows Arch. 2002;441:406–11.

    Article  PubMed  Google Scholar 

  28. Abe T, Hosokawa M, Kusumi T, Kusano M, Hokari K, Kagaya H, et al. Adenocarcinoma arising from ectopic gastric mucosa in the cervical esophagus. Am J Clin Oncol. 2004;27:644–5.

    Article  PubMed  Google Scholar 

  29. Alrawi SJ, Winston J, Tan D, Gibbs J, Loree TR, Hicks W, et al. Primary adenocarcinoma of cervical esophagus. J Exp Clin Cancer Res. 2005;24:325–30.

    PubMed  CAS  Google Scholar 

  30. Hoshino A, Otuka Y, Nara S, Harihara Y, Konishi T. A case of primary adenocarcinoma of the cervical esophagus arising from the ectopic gastric mucosa. Esophagus. 2007;4:83–6.

    Article  Google Scholar 

  31. Alagozlu H, Ergun M, Cindruk M, Unal S, Dumlu S, et al. The rare presentations of a large polyps, an esophageal carcinoma in heterotopic gastric mucosa: a case series. J Med Case Rep. 2007;1:127.

    Article  PubMed  Google Scholar 

  32. Young OH, Jeong EH, In-Chul L, Jin-Hyuk L, Seung-Il P, Kyung-Ja C. Adenocarcinoma arising from heterotopic gastric mucosa in cervical esophagus. Korean J Pathol. 2008;42:33–6.

    Google Scholar 

  33. Komori S, Osada S, Tanaka Y, Takahashi T. A case of esophageal adenocarcinoma arising from the ectopic gastric mucosa in the thoracic esophagus. Rare Tumors. 2010;2:12–5.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kawaramachi-hirokoji, Kamigyo-ku, Kyoto, 602-8566, Japan

    Daisuke Iitaka, Hitoshi Fujiwara, Atsushi Shiozaki, Takeshi Kubota, Yasutoshi Murayama, Shuhei Komatsu, Yoshiaki Kuriu, Hisashi Ikoma, Masayoshi Nakanishi, Daisuke Ichikawa, Kazuma Okamoto, Toshiya Ochiai, Yukihito Kokuba & Eigo Otsuji

  2. Department of Gastrointestinal Medicine, Social Insurance Kyoto Hospital, 27 Shimofusa-cho, Oyama, Kita-ku, Kyoto, 603-8151, Japan

    Takashi Ando

Authors
  1. Daisuke Iitaka
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Hitoshi Fujiwara
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Atsushi Shiozaki
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Takeshi Kubota
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Takashi Ando
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Yasutoshi Murayama
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Shuhei Komatsu
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Yoshiaki Kuriu
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Hisashi Ikoma
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Masayoshi Nakanishi
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. Daisuke Ichikawa
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. Kazuma Okamoto
    View author publications

    You can also search for this author in PubMed Google Scholar

  13. Toshiya Ochiai
    View author publications

    You can also search for this author in PubMed Google Scholar

  14. Yukihito Kokuba
    View author publications

    You can also search for this author in PubMed Google Scholar

  15. Eigo Otsuji
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Hitoshi Fujiwara.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Iitaka, D., Fujiwara, H., Shiozaki, A. et al. Double primary cancer of the esophagus consisting of ectopic gastric mucosa-derived adenocarcinoma and squamous cell carcinoma: a first case report. Esophagus 8, 303–309 (2011). https://doi.org/10.1007/s10388-011-0296-2

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10388-011-0296-2

Keywords

Search

Navigation