Skip to main content

Advertisement

Log in

An esophageal squamous cell carcinoma patient with high serum granulocyte-colony stimulating factor level: report of a case

  • Case Report
  • Published:
Esophagus Aims and scope Submit manuscript

Abstract

We present herein a case of a patient who was clinically diagnosed as having a granulocyte-colony stimulating factor (G-CSF)-producing tumor on the basis of the close correlation of the hematological parameters with the tumor status and his high serum G-CSF level. A 76-year-old male patient underwent transthoracic radical esophagectomy for advanced carcinoma of the lower esophagus. His leukocyte count and serum G-CSF level were markedly high at 24 260/μl and 134 pg/ml, respectively, before the operation. By immunohistochemical staining of the resected tumor, focal but obvious expression of G-CSF was demonstrated in the cytoplasm of cancer cells, and neutrophilic infiltration was histologically observed in adjacent struma of the tumor invasion front. After surgery, the leukocyte count decreased to a nearly normal level but increased again when the disease recurred in the pleura and lymph nodes 5 months later. Although palliative chemoradiotherapy decreased the leukocyte count to a normal level transiently, leukocyte count again markedly increased when metastatic disease occurred. The leukocyte count reached 78 060/μl the day before the patient died.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Asano S, Urabe A, Okabe T, Sato N, Kondo Y, Ueyama Y, et al. Demonstration of granulopoietic factor(s) in the plasma of nude mice transplanted with a human lung cancer and in the tumor tissue. Blood 1977;49:845–852.

    CAS  PubMed  Google Scholar 

  2. Abe Y, Nakamura M, Katoh Y, Ogawa J, Inoue H, Tada N. A case report of lung cancer producing granulocyte colony-stimulating factor that induced leukocytosis (in Japanese with English abstract). Jpn J Lung Cancer 1992;32:279–284.

    Google Scholar 

  3. Hasegawa S, Suda T, Negi K, Hattori Y. Lung large cell carcinoma producing granulocyte-colony-stimulating factor. Ann Thorac Surg 2007;83:308–310.

    Article  PubMed  Google Scholar 

  4. Endo K, Kohnoe S, Okamura T, Haraguti M, Adachi E, Toh Y, et al. Gastric adenosquamous carcinoma producing granulocytecolony stimulating factor. Gastric Cancer 2005;8:173–177.

    Article  CAS  PubMed  Google Scholar 

  5. Uji Y, Kusano T, Iida H, Yuzawa H, Takao T, Shimabukuro M, et al. A case of granulocyte-colony stimulating factor producing gastric carcinoma (in Japanese with English abstract). Jpn J Gastroenterol Surg 2006;39:653–659.

    Google Scholar 

  6. Yamano T, Morii E, Ikeda J, Aozasa K. Granulocyte-colony stimulating factor production and rapid progression of gastric cancer after histological change in the tumor. Jpn J Clin Oncol 2007;37:793–796.

    Article  PubMed  Google Scholar 

  7. Aita K, Seki K. Carcinosarcoma of the liver producing granulocyte-colony stimulating factor. Pathol Int 2006;56:413–419.

    Article  PubMed  Google Scholar 

  8. Furihata M, Shinobe H, Ohtsuki Y, Enzan H, Tokuoka H, Nakanuma Y. An immunohistochemical study on a case of granulocyte-colony stimulating factor-producing gall-bladder carcinoma. Pathol Int 1999;49:1010–1013.

    Article  CAS  PubMed  Google Scholar 

  9. Kawakami H, Kuwatani M, Fujita Y, Uebayashi M, Konishi K, Makiyama H, et al. A case of granulocyte-colony stimulating factor producing ductal adenocarcinoma of the pancreas (in Japanese with English abstract). J Jpn Soc Gastroenterol 2007;104:233–238.

    Google Scholar 

  10. Ando N, Fukuhara S, Mizuno Y, Ando H. A case of granulocytecolony stimulating factor producing anaplastic ductal carcinoma of pancreas (in Japanese with English abstract). Jpn J Gastroenterol Surg 2005;38:318–323.

    Google Scholar 

  11. Tachibana M, Miyakawa A, Tazaki H, Nakamura K, Kubo A, Hata J, et al. Autocrine growth of transitional cell carcinoma of the bladder induced by granulocyte-colony stimulating factor. Cancer Res 1995;55:3438–3443.

    CAS  PubMed  Google Scholar 

  12. Ota S, Kato A, Kobayashi H, Yonezumi M, Yamaguchi J, Musashi M, et al. Monoclonal origin of an esophageal carcinosarcoma producing granulocyte-colony stimulating factor: a case report. Cancer (Phila) 1998;82:2102–2111.

    Article  CAS  Google Scholar 

  13. Asai K, Igarashi S, Shimizu H, Miyata H, Horiguchi J. A case of rapidly enlarged G-CSF producing esophageal so-called carcinosarcoma showing a variety of lesions (in Japanese with English abstract). Jpn J Gastroenterol Surg 2003;36:464–469.

    Google Scholar 

  14. Fujimori M, Ono K, Manase H, Yanagi S, Suzuki O, Shiono T. A case of G-CSF producing esophageal carcinosarcoma with strong inflammatory reaction (in Japanese with English abstract). J Jpn Surg Assoc 2003;64:1094–1097.

    Google Scholar 

  15. Sato Y, Takahashi Y, Nishiie K, Okubo S, Fujikawa K, Shinntani N, et al. A case of granulocyte-colony stimulating factor producing small cell carcinoma of esophagus (in Japanese with English abstract). J Jpn Soc Gastroenterol 2005;102:888–893.

    Google Scholar 

  16. Maejima K, Watanabe M, Komine O, Mizutani S, Bou H, Tokunaga A, et al. Granulocyte-colony stimulating factor-producing esophageal carcinosarcoma: a case report. Esophagus 2007;4:117–120.

    Article  Google Scholar 

  17. Sasaki K, Natsugoe S, Higashi M, Okumura H, Matsumoto M, Hanazono K, et al. Esophageal carcinosarcoma with granulocyte colony-stimulating factor: a case report. Esophagus 2007;4:129–134.

    Article  Google Scholar 

  18. Miyamoto K, Shibata S, Kawasaki H. Carcinosarcoma of the esophagus producing granulocyte colony-stimulating factor: report of a case. Esophagus 2008;5:171–175.

    Article  Google Scholar 

  19. Mimatsu K, Oida T, Kano H, Kawasaki A, Amano S. Aggressive progression of granulocyte colony-stimulating factor producing squamous cell carcinoma of the esophagus: case report and literature review. Esophagus 2008;5:205–209.

    Article  Google Scholar 

  20. Guidelines for the clinical and pathologic studies on carcinoma of the esophagus, 9th ed. Preface, general principles, part I. Japanese Society for Esophageal Diseases. Esophagus 2004;1:61–88.

  21. Tsutsumi Y, Shimomura R. In situ hybridization method (in Japanese). Pathol Clin Med 2005;23:543–551.

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Tatsuo Kanda.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Tanabe, T., Kanda, T., Ishihara, N. et al. An esophageal squamous cell carcinoma patient with high serum granulocyte-colony stimulating factor level: report of a case. Esophagus 6, 253–258 (2009). https://doi.org/10.1007/s10388-009-0206-z

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10388-009-0206-z

Key words

Navigation