Skip to main content

Advertisement

SpringerLink
Log in

A case report of mucosal Barrett's cancer with vessel involvement, with special reference to indications for endoscopic mucosal ablation therapy

  • CASE REPORT
  • Published:
Esophagus Aims and scope Submit manuscript

Abstract

We present a 72-year-old female patient with mucosal Barrett's cancer. Although preoperative diagnosis suggested tumor invasion throughout the mucosal layer, she was treated by endoscopic mucosal resection at her preference. The tumor invasion depth was “m-3.” However, tumor cells were observed along the endothelium of a small vein. Following endoscopic treatment, ultimately the patient underwent radical surgery. Neither residual tumor nor lymph node metastasis was found in the resected specimens. We also reviewed published reports regarding the relationship between tumor depth and vessel involvement in early-stage Barrett's cancer. In Barrett's cancer with a tumor invasion of m-3 where tumor had invaded throughout the mucosal layer, blood or lymphatic vessel invasion was observed in 12.5% of cases (6/48). However, no lymph node metastasis was found. Therefore, we considered that endoscopic mucosal ablation therapy may be applicable to treat intramucosal Barrett's cancer with a tumor invasion depth of m-3.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. MI Canto S Setrakian RE Petras E Blades A Chak MK Sivak SuffixJr (1996) ArticleTitleMethylene blue selectively stains intestinal metaplasia in Barrrett's esophagus Gastrointest Endosc 44 1–7 Occurrence Handle1:STN:280:BymH3sznt10%3D Occurrence Handle8836709 Occurrence Handle10.1016/S0016-5107(96)70221-3

    Article  CAS  PubMed  Google Scholar 

  2. Y Amano Y Kushiyama S Ishihara T Yuki Y Miyaoka N Yoshinio et al. (2005) ArticleTitleCrystal violet chromoendoscopy with mucosal pit pattern diagnosis is useful for surveillance of short segment Barrett's esophagus Am J Gastroenterol 100 21–6 Occurrence Handle15654776 Occurrence Handle10.1111/j.1572-0241.2005.40028.x

    Article  PubMed  Google Scholar 

  3. M Guelrud I Herrera H Essenfeld J Castro (2001) ArticleTitleEnhanced magnification endoscopy: a new technique to identify specialized intestinal metaplasia in Barrett's esophagus Gastrointest Endosc 53 559–65 Occurrence Handle1:STN:280:DC%2BD3MvkvVKltw%3D%3D Occurrence Handle11323579 Occurrence Handle10.1067/mge.2001.114059

    Article  CAS  PubMed  Google Scholar 

  4. P Sharma AP Weston M Topalovski R Cherian A Bhattacharyya RE Sampliner (2003) ArticleTitleMagnification chromoendoscopy for the detection of intestinal metaplasia and dysplasia in Barrett's oesophagus Gut 52 24–7 Occurrence Handle1:STN:280:DC%2BD3s%2FgsVClsA%3D%3D Occurrence Handle12477754 Occurrence Handle10.1136/gut.52.1.24

    Article  CAS  PubMed  Google Scholar 

  5. A May L Gossner E Gunter M Stolte C Ell (1999) ArticleTitleLocal treatment of early cancer in short Barrett's esophagus by means of argon plasma coagulation: intial experience Endoscopy 31 497–500 Occurrence Handle1:STN:280:DyaK1Mvit1yrtg%3D%3D Occurrence Handle10494693 Occurrence Handle10.1055/s-1999-44

    Article  CAS  PubMed  Google Scholar 

  6. RJ Pacifico KK Wang LM Wongkeesong NS Buttar LS Lutzke (2003) ArticleTitleCombined endoscopic mucosal resection and photodynamic therapy versus esophaectomy for management of early adenocarcinoma in Barrett's esophagus Clin Gastroenterol Hepatol 1 252–7 Occurrence Handle15017665 Occurrence Handle10.1016/S1542-3565(03)00129-0

    Article  PubMed  Google Scholar 

  7. SE Attwood CJ Lewis S Caplin K Hemming G Armstrong (2003) ArticleTitleArgon beam plasma coagulation as therapy for high-grade dysplasia in Barrett's esophagus Clin Gastroenterol Hepatol 1 258–63 Occurrence Handle15017666 Occurrence Handle10.1016/S1542-3565(03)00128-9

    Article  PubMed  Google Scholar 

  8. S Seewald T Akaraviputh U Seitz B Brand S Groth G Mendoza et al. (2003) ArticleTitleCircumferential EMR and complete removal of Barrett's epithelium: a new approach to Barrett's esophagus containing high-grade intraepithelial neoplasia and intramucosal carcinoma Gastrointest Endosc 57 854–9 Occurrence Handle12776032 Occurrence Handle10.1016/S0016-5107(03)70020-0

    Article  PubMed  Google Scholar 

  9. BF Overholt M Panjehpour DJ Halberg (2003) ArticleTitlePhotodynamic therapy for Barrett's esophagus with dysplasia and/or early stage carcinoma: long-term results Gastrointest Endosc 58 183–8 Occurrence Handle12872083

    PubMed  Google Scholar 

  10. H Makuuchi (1996) ArticleTitleEndoscopic mucosal resection for early esophageal cancer Dig Endosc 8 175–9

    Google Scholar 

  11. T Karube T Ochiai H Shimada T Nikaidou H Hayashi (2004) ArticleTitleDetection of sentinel lymph nodes in gastric cancers based on immunohistochemical analysis of micrometastases J Surg Oncol 87 32–8 Occurrence Handle15221917 Occurrence Handle10.1002/jso.20077

    Article  PubMed  Google Scholar 

  12. X Jiao A Eslami O Ioffe KF Kwong M Henry Q Zeng et al. (2003) ArticleTitleImmunohistochemistry analysis of micrometastasis in pretreatment lymph nodes from patients with esophageal cancer Ann Thorac Surg 76 996–9 Occurrence Handle14529974 Occurrence Handle10.1016/S0003-4975(03)00658-1

    Article  PubMed  Google Scholar 

  13. L Bonavina S Ferrero V Midolo R Buffa B Cesana A Peracchia (1999) ArticleTitleLymph node micrometastases in patients with adenocarcinoma of the esophagogastric junction J Gastrointest Surg 3 468–76 Occurrence Handle1:STN:280:DyaK1Mvht1GmtA%3D%3D Occurrence Handle10482702

    CAS  PubMed  Google Scholar 

  14. Yuki T, Amano Y, Kushiyama Y, Takahashi Y, Ose T, Moriyama I, et al. Evaluation of modified crystal violet chromoendoscopy procedure using new mucosal pit pattern classification for detection of Barrett's dysplastic lesions. Dig Liv Dis (in press)

  15. M Hongo T Shoji (2003) ArticleTitleEpidemiology of reflux disease and CLE in East Asia J Gastroenterol 38 IssueIDsuppl 15 25–30 Occurrence Handle12698867

    PubMed  Google Scholar 

  16. A Zeniya T Ishioka O Masamune Y Uesaka M Sato (1995) ArticleTitleSuperficial adenocarcinoma arising from Barrett's esophagus (abstract in English). Report of a case Stomach Intest (Tokyo) 30 1445–50

    Google Scholar 

  17. T Nishi H Makuuchi T Machimura K Mizutani H Shimada K Kanno et al. (1995) ArticleTitleA small adenocarcinoma arising in Barrett's esophagus: a case report (abstract in English) Endosc Dig 7 557–63

    Google Scholar 

  18. H Shimoji H Miyazato A Nakachi H Matsubara O Tamai T Isa et al. (1998) ArticleTitleBarrett's adomocarcinoma associated with acquired eventration of the diaphragm Gastric Cancer 1 84–8 Occurrence Handle11957049

    PubMed  Google Scholar 

  19. T Fujisawa M Maeda T Nishigami H Ogino T Sakamoto T Maeda et al. (1999) ArticleTitleEarly esophageal adenocarcinoma arising in short segment Barrett's esophagus (abstract in English). Report of a case Stomach Intest (Tokyo) 34 207–14

    Google Scholar 

  20. S Hironaka N Boku A Ohtsu A Ochiai S Yoshida Y Ejiri (2001) ArticleTitleEndoscopic mucosal resection for early adenocarcinoma arising in Barrett's esophagus Dig Endosc 13 104–7 Occurrence Handle10.1046/j.1443-1661.2001.00100.x

    Article  Google Scholar 

  21. T Inoue Y Hatada K Kanazawa M Saitou (2001) ArticleTitleEndoscopicaly resected early adenocarcinoma in short segment Barretts esophagus (abstract in English) Gastroenterol Endosc 43 2220–4

    Google Scholar 

  22. O Hosokawa Y Umizaki Y Hayashi K Douden M Hattori K Watanabe et al. (2001) ArticleTitleProtruding undifferentiated adenocarcinoma invading as far as the submucosal layer in the esophagogastric junction (abstract in English). Report of a case Stomach Intest (Tokyo) 36 703–7

    Google Scholar 

  23. Y Takaki S Sou H Nomura F Matsubara R Shirai T Yao et al. (2001) ArticleTitleSuperficial adenocarcinoma arising in Barrett's esophagus (abstract in English). Report of a case Stomach Intest (Tokyo) 36 709–15

    Google Scholar 

  24. N Saito J Fujisaki Y Arai T Nakayoshi S Katsura K Mochizuki et al. (2002) ArticleTitleA case of early esophageal adenocarcinoma originated from short segment Barrett's esophagus, resected by endoscopic mucosal resection (abstract in English) Gastroenterol Endosc 44 11–6

    Google Scholar 

  25. T Kouzu E Hishikawa K Nakashima Y Suzuki K Yoshimura S Miyazaki et al. (2002) ArticleTitleFollow-up for cases of Barrett's adenocarcinoma (abstract in English) Endosc Dig 14 1145–9

    Google Scholar 

  26. T Ito T Takizawa (2002) ArticleTitleHistopathological diagnosis of Barrett's adenocarcinoma (abstract in English) Endosc Dig 14 1151–7

    Google Scholar 

  27. T Kazawa K Momma M Yoshida H Katoh T Hanashi Y Izumi et al. (2002) ArticleTitleA case report on well-differentiated adenocarcinoma derived from Barrett's esophagus (abstract in English) Endosc Dig 14 1167–72

    Google Scholar 

  28. K Yamada M Tanaka S Inatsuchi N Maeda (2002) ArticleTitleSuperficial Barrett's adenocarcinoma: report of a case (abstract in English) Endosc Dig 14 1173–6

    Google Scholar 

  29. T Yamane T Ishii M Nakamura Y Sato T Furuya K Fujise et al. (2002) ArticleTitleA case of cauterization therapy for Barrett's epithelium which expanded after endoscopic mucosal resection for mucosal adenocarcinoma (abstract in English) Gastroenterol Endosc 44 1067–72

    Google Scholar 

  30. HJ Stein M Feith BA Rahden JR Siewert (2003) ArticleTitleApproach to early Barrett's cancer World J Surg 27 1040–6 Occurrence Handle12917759

    PubMed  Google Scholar 

  31. DC Farrow TL Vaughan (1996) ArticleTitleDeterminants of survival following the diagnosis of esophageal adenocar cinoma (United States) Cancer Causes Control 7 322–7 Occurrence Handle1:STN:280:BymA3Mjgt1E%3D Occurrence Handle8734825 Occurrence Handle10.1007/BF00052937

    Article  CAS  PubMed  Google Scholar 

  32. S Nakagawa H Watanabe (1994) ArticleTitleMucosal carcinomas of the esophagus. Their subclassification of depth of invasion, histologic risk factors and macroscopic features (abstract in English) Stomach Intest (Tokyo) 29 273–88

    Google Scholar 

  33. H Makuuchi H Shimada O Chino Y Tanaka Y Kise T Nishi et al. (2002) ArticleTitleLong term prognosis of m3, sm1 cancer of the esophagus: comparison between EMR and radical surgery cases (abstract in English) Stomach Intest (Tokyo) 37 53–63

    Google Scholar 

  34. H Suzuki M Endo S Suzuki T Hasegawa Y Kitamura S Saito et al. (1984) ArticleTitleA study of the lymph node metastasis of early gastric cancer (abstract in English) Jpn J Gastroenterol Surg 17 1517–26

    Google Scholar 

  35. T Boku Y Nakane T Okusa M Okamoto S Okamura S Kasamatsu et al. (1990) ArticleTitleEvaluation of the frequency of lymph node metastasis and the number of metastasized lymph nodes in gastric carcinoma (abstract in English) Jpn J Gastroenterol Surg 23 841–50

    Google Scholar 

  36. S Natsugoe M Baba H Yoshinaka F Kijima M Shimada K Shirao et al. (1998) ArticleTitleMucosal squamous cell carcinoma of the esophagus: a clinicopathologic study of 30 cases Oncology 52 235–41

    Google Scholar 

  37. MM Owens MB Kimmey (2003) ArticleTitleThe role of endoscopic ultrasound in the diagnosis and management of Barrett's esophagus Gastrointest Endosc Clin N Am 13 325–34 Occurrence Handle12916663 Occurrence Handle10.1016/S1052-5157(03)00014-X

    Article  PubMed  Google Scholar 

  38. AL Adrain HC Ter MJ Cassidy TD Schiano JB Liu LS Miller (1997) ArticleTitleHigh-resolution endoluminal sonography is a sensitive modality for the identification of Barrett's metaplasia Gastrointest Endosc 46 147–51 Occurrence Handle1:STN:280:ByiH38bltFE%3D Occurrence Handle9283865 Occurrence Handle10.1016/S0016-5107(97)70063-4

    Article  CAS  PubMed  Google Scholar 

  39. IA Scotiniotis ML Kochman JD Lewis EE Furth EF Rosato GG Ginsberg (2001) ArticleTitleAccuracy of EUS in the evaluation of Barrett's esophagus and high-grade dysplasia or intramucosal carcinoma Gastrointest Endosc 54 689–96 Occurrence Handle1:STN:280:DC%2BD3MnotVersg%3D%3D Occurrence Handle11726843

    CAS  PubMed  Google Scholar 

  40. K Takubo K Sasajima K Yamashita Y Tanaka K Fujita (1991) ArticleTitleDouble muscularis mucosae in Barrett's esophagus Hum Pathol 22 1158–61 Occurrence Handle1:STN:280:By2D2sjmsFM%3D Occurrence Handle1743701 Occurrence Handle10.1016/0046-8177(91)90270-Y

    Article  CAS  PubMed  Google Scholar 

  41. CA Rubio R Riddell (1988) ArticleTitleMusculo-fibrous anomaly: Barrett's mucosa with dysplasia Am J Surg Pathol 12 885–9 Occurrence Handle1:STN:280:BiaD2cfgsVA%3D Occurrence Handle3189695

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Gastroenterology and Hepatology, Shimane University, School of Medicine, Izumo, Japan

    Takafumi Yuki, Yoshiko Takahashi, Takayuki Ose, Ichiro Moriyama, Yoshinori Kushiyama, Kenji Furuta, Shunji Ishihara, Kyoichi Adachi & Yoshikazu Kinoshita

  2. Division of Gastrointestinal Endoscopy, Shimane University Hospital, 89-1 Enya-cho, Izumo, 693-8501, Japan

    Yuji Amano & Tatsuya Miyake

Authors
  1. Takafumi Yuki
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Yuji Amano
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Yoshiko Takahashi
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Takayuki Ose
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Ichiro Moriyama
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Tatsuya Miyake
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Yoshinori Kushiyama
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Kenji Furuta
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Shunji Ishihara
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Kyoichi Adachi
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. Yoshikazu Kinoshita
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Yuji Amano.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Yuki, T., Amano, Y., Takahashi, Y. et al. A case report of mucosal Barrett's cancer with vessel involvement, with special reference to indications for endoscopic mucosal ablation therapy. Esophagus 3, 19–22 (2006). https://doi.org/10.1007/s10388-005-0065-1

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10388-005-0065-1

Key words

Search

Navigation